中华中医药学刊

黄芩有效成分抗多器官纤维化的研究进展

PDF下载

高鉴 , 吴宣諭 , 鲜文佳 , 邹雨彤 , 吴程 , 杜全宇 , 王飞

中华中医药学刊 | 国家项目点击 2026,44(2): 85-92

收起

中华中医药学刊 |国家项目点击 2026 , 44 (2) : 85 -92

黄芩有效成分抗多器官纤维化的研究进展

全屏

[Author(id=1319630943556584275, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319630943636276053, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, authorId=1319630943556584275, language=EN, stringName=Jian GAO, firstName=Jian, middleName=null, lastName=GAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319630943724356438, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, authorId=1319630943556584275, language=CN, stringName=高鉴, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=成都中医药大学附属医院，四川成都 610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319630943455920975, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, xref=null, ext=[AuthorCompanyExt(id=1319630943468503888, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, companyId=1319630943455920975, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1319630943481086801, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, companyId=1319630943455920975, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川成都 610072)])]), Author(id=1319630943820825432, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319630943925683034, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, authorId=1319630943820825432, language=EN, stringName=Xuanyu WU, firstName=Xuanyu, middleName=null, lastName=WU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319630944001180507, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, authorId=1319630943820825432, language=CN, stringName=吴宣諭, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=成都中医药大学附属医院，四川成都 610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319630943455920975, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, xref=null, ext=[AuthorCompanyExt(id=1319630943468503888, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, companyId=1319630943455920975, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1319630943481086801, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, companyId=1319630943455920975, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川成都 610072)])]), Author(id=1319630944055706461, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319630944156369759, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, authorId=1319630944055706461, language=EN, stringName=Wenjia XIAN, firstName=Wenjia, middleName=null, lastName=XIAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319630944223478624, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, authorId=1319630944055706461, language=CN, stringName=鲜文佳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=成都中医药大学附属医院，四川成都 610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319630943455920975, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, xref=null, ext=[AuthorCompanyExt(id=1319630943468503888, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, companyId=1319630943455920975, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1319630943481086801, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, companyId=1319630943455920975, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川成都 610072)])]), Author(id=1319630944286393186, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319630944349307748, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, authorId=1319630944286393186, language=EN, stringName=Yutong ZOU, firstName=Yutong, middleName=null, lastName=ZOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319630946043806565, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, authorId=1319630944286393186, language=CN, stringName=邹雨彤, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=成都中医药大学附属医院，四川成都 610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319630943455920975, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, xref=null, ext=[AuthorCompanyExt(id=1319630943468503888, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, companyId=1319630943455920975, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1319630943481086801, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, companyId=1319630943455920975, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川成都 610072)])]), Author(id=1319630946127692647, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319630946236744553, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, authorId=1319630946127692647, language=EN, stringName=Cheng WU, firstName=Cheng, middleName=null, lastName=WU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319630946559705962, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, authorId=1319630946127692647, language=CN, stringName=吴程, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=成都中医药大学附属医院，四川成都 610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319630943455920975, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, xref=null, ext=[AuthorCompanyExt(id=1319630943468503888, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, companyId=1319630943455920975, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1319630943481086801, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, companyId=1319630943455920975, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川成都 610072)])]), Author(id=1319630946626814828, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319630946719089518, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, authorId=1319630946626814828, language=EN, stringName=Quanyu DU, firstName=Quanyu, middleName=null, lastName=DU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319630946794586991, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, authorId=1319630946626814828, language=CN, stringName=杜全宇, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=成都中医药大学附属医院，四川成都 610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319630943455920975, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, xref=null, ext=[AuthorCompanyExt(id=1319630943468503888, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, companyId=1319630943455920975, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1319630943481086801, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, companyId=1319630943455920975, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川成都 610072)])]), Author(id=1319630946861695857, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319630947042050931, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, authorId=1319630946861695857, language=EN, stringName=Fei WANG, firstName=Fei, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319630947109159796, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, authorId=1319630946861695857, language=CN, stringName=王飞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=成都中医药大学附属医院，四川成都 610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319630943455920975, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, xref=null, ext=[AuthorCompanyExt(id=1319630943468503888, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, companyId=1319630943455920975, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1319630943481086801, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317125616374240233, companyId=1319630943455920975, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川成都 610072)])])]

高鉴, 吴宣諭, 鲜文佳, 邹雨彤, 吴程, 杜全宇, 王飞

作者信息

成都中医药大学附属医院，四川成都 610072

Research Progress on Mechanism of Effective Components of Huangqin（Scutellariae Radix）against Multiple Organ Fibrosis

Jian GAO, Xuanyu WU, Wenjia XIAN, Yutong ZOU, Cheng WU, Quanyu DU, Fei WANG

Affiliations

Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China

出版时间: 2026-02-10 doi: 10.13193/j.issn.1673-7717.2026.02.016

文章导航

摘要

收起

纤维化是一个高度动态的病理生理过程，能影响多种器官，其特征主要是细胞外基质过度积聚。纤维化的发病机制复杂，严重时可导致器官功能衰竭，目前缺乏特效药物。近年来，黄芩在多种器官纤维化的治疗中都表现出积极作用。因此，检索了6个常用生物医学数据库，对近20年黄芩治疗纤维化疾病的文献进行了综述，发现黄芩抗纤维化成分主要包括黄芩苷、黄芩素、汉黄芩苷、野黄芩苷等。主要通过调控细胞自噬与凋亡、抑制成纤维细胞转化、抗氧化应激等途径发挥抗纤维化作用，是具有积极临床意义的潜在抗纤维化药物。

关键词

黄芩苷 / 黄芩素 / 汉黄芩苷 / 千纸层素A / 野黄芩苷 / 纤维化

Abstract

收起

Organ fibrosis is a highly dynamic pathophysiological process that can affect multiple organs，characterized by excessive accumulation of extracellular matrix. The pathogenesis of fibrosis is complex，and in severe cases，it can lead to organ failure. Currently，there is a lack of specific drugs. In recent years，it is found that Huangqin（Scutellariae Radix）has shown positive effects in various organ fibrosis. Therefore，this study searched six commonly used biomedical databases and analyzed the literature on the treatment of fibrosis diseases with Huangqin（Scutellariae Radix）in the past 20 years. This study has found that the anti-fibrotic components of Huangqin（Scutellariae Radix）mainly include baicalin，baicalein，wogonoside，scutellarin，etc. Huangqin（Scutellariae Radix）mainly exerts its anti-fibrotic effect by inhibiting fibroblast transformation，preventing fibroblast proliferation，reducing extracellular matrix deposition，antioxidant stress and regulating fibrotic related pathways. In summary，Huangqin（Scutellariae Radix）is a potential anti-fibrotic drug with positive clinical significance.

Key words

baicalin / baicalein / oroxindin / oroxylin A / scutellarin / fibrosis

引用本文

高鉴, 吴宣諭, 鲜文佳, 邹雨彤, 吴程, 杜全宇, 王飞. 黄芩有效成分抗多器官纤维化的研究进展. 中华中医药学刊, 2026 , 44 (2) : 85 -92 . DOI: 10.13193/j.issn.1673-7717.2026.02.016

Jian GAO, Xuanyu WU, Wenjia XIAN, Yutong ZOU, Cheng WU, Quanyu DU, Fei WANG. Research Progress on Mechanism of Effective Components of Huangqin（Scutellariae Radix）against Multiple Organ Fibrosis[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (2) : 85 -92 . DOI: 10.13193/j.issn.1673-7717.2026.02.016

参考文献

收起

文献

收起

参考文献引证文献

排序方式：

［1］

HENDERSON N C，RIEDER F，WYNN T A. Fibrosis：from mechanisms to medicines［J］. Nature，2020，587（7835）：555-566.

［2］

ZHAO X，KWAN J Y Y，YIP K，et al. Targeting metabolic dysregulation for fibrosis therapy［J］. Nat Rev Drug Discov，2020，19（1）：57-75.

［3］

NASTASE M V，ZENG-BROUWERS J，WYGRECKA M，et al. Targeting renal fibrosis：Mechanisms and drug delivery systems［J］. Adv Drug Deliv Rev，2018，129：295-307.

［4］

DU Y F，MA J，FAN Y，et al. Naringenin：a promising therapeutic agent against organ fibrosis［J］. Oxid Med Cell Longev，2021，2021：1210675.

［5］

AFRATIS N A，KLEPFISH M，KARAMANOS N K，et al. The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis：Applications to drug discovery［J］. Adv Drug Deliv Rev，2018，129：4-15.

［6］

XIANG L，GAO Y，CHEN S Y，et al. Therapeutic potential of Scutellaria baicalensis Georgi in lung cancer therapy［J］. Phytomedicine，2022，95：153727.

［7］

ZHAO T T，TANG H L，XIE L，et al. Scutellaria baicalensis Georgi.（Lamiaceae）：a review of its traditional uses，botany，phytochemistry，pharmacology and toxicology［J］. J Pharm Pharmacol，2019，71（9）：1353-1369.

［8］

HOU F F，YU Z Y，CHENG Y，et al. Deciphering the pharmacological mechanisms of Scutellaria baicalensis Georgi on oral leukoplakia by combining network pharmacology，molecular docking and experimental evaluations［J］. Phytomedicine，2022，103：154195.

［9］

FANG D N，ZHENG C W，MA Y L. Effectiveness of Scutellaria baicalensis Georgi root in pregnancy-related diseases：a review［J］. J Integr Med，2023，21（1）：17-25.

［10］

TAN Y Q，LIN F，DING Y K，et al. Pharmacological properties of total flavonoids in Scutellaria baicalensis for the treatment of cardiovascular diseases［J］. Phytomedicine，2022，107：154458.

［11］

WANG P W，LIN T Y，YANG P M，et al. Therapeutic efficacy of Scutellaria baicalensis Georgi against psoriasis-like lesions via regulating the responses of keratinocyte and macrophage［J］. Biomed Pharmacother，2022，155：113798.

［12］

RAGHU G，REMY-JARDIN M，RICHELDI L，et al. Idiopathic pulmonary fibrosis（an update）and progressive pulmonary fibrosis in adults：an official ATS/ERS/JRS/ALAT clinical practice guideline［J］. Am J Respir Crit Care Med，2022，205（9）：e18-e47.

［13］

THANNICKAL V J，TOEWS G B，WHITE E S，et al. Mechanisms of pulmonary fibrosis［J］. Annu Rev Med，2004，55：395-417.

［14］

MAHER T M，BENDSTRUP E，DRON L，et al. Global incidence and prevalence of idiopathic pulmonary fibrosis［J］. Respir Res，2021，22（1）：197.

［15］

RICHELDI L，DU BOIS R M，RAGHU G，et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis［J］. N Engl J Med，2014，370（22）：2071-2082.

［16］

WANG Z L，WANG S，KUANG Y，et al. A comprehensive review on phytochemistry，pharmacology，and flavonoid biosynthesis of Scutellaria baicalensis［J］. Pharm Biol，2018，56（1）：465-484.

［17］

张沂，穆杰，高伟华，等.基于网络药理学从系统层面探讨黄芩苷治疗肺纤维化的效应机制研究［J］.世界中医药，2020，15（10）：1373-1380.

［18］

KLIONSKY D J，PETRONI G，AMARAVADI R K，et al. Autophagy in major human diseases［J］. EMBO J，2021，40（19）：e108863.

［19］

BERTHELOOT D，LATZ E，FRANKLIN B S. Necroptosis，pyroptosis and apoptosis：an intricate game of cell death［J］. Cell Mol Immunol，2021，18（5）：1106-1121.

［20］

ARAYA J，KOJIMA J，TAKASAKA N，et al. Insufficient autophagy in idiopathic pulmonary fibrosis［J］. Am J Physiol Lung Cell Mol Physiol，2013，304（1）：L56-L69.

［21］

QIAO D，LI Y S，XING J，et al. Baicalein inhibits PI3K/AKT signaling pathway and induces autophagy of MGC-803 cells［J］. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi，2019，35（7）：613-618.

［22］

HANSON K M，HERNADY E B，REED C K，et al. Apoptosis resistance in fibroblasts precedes progressive scarring in pulmonary fibrosis and is partially mediated by toll-like receptor 4 activation［J］. Toxicol Sci，2019，170（2）：489-498.

［23］

MIAO K，PAN T，MOU Y，et al. Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation，proliferation，and apoptosis［J］. Ther Adv Chronic Dis，2020，11：2040622320940185.

［24］

SIES H. Oxidative stress：a concept in redox biology and medicine［J］. Redox Biol，2015，4：180-183.

［25］

OTOUPALOVA E，SMITH S，CHENG G J，et al. Oxidative stress in pulmonary fibrosis［J］. Compr Physiol，2020，10（2）：509-547.

［26］

BAO M L，LIANG M，SUN X Y，et al. Baicalin alleviates LPS-induced oxidative stress via NF-κB and Nrf2-HO1 signaling pathways in IPEC-J2 cells［J］. Front Vet Sci，2022，8：808233.

［27］

蔡健，顾振纶，蒋小岗，等.黄芩总黄酮对博莱霉素致大鼠肺纤维化的干预作用及其机制研究［J］.中草药，2012，43（1）：119-124.

［28］

聂娟.野黄芩苷对博来霉素引起的肺纤维化的治疗作用及机制研究［D］.广州：广州中医药大学，2021.

［29］

LIN Y T，WU K J. Epigenetic regulation of epithelial-mesenchymal transition：focusing on hypoxia and TGF-β signaling［J］. J Biomed Sci，2020，27（1）：39.

［30］

GAO Y，LU J，ZHANG Y，et al. Baicalein attenuates bleomycin-induced pulmonary fibrosis in rats through inhibition of miR-21［J］. Pulm Pharmacol Ther，2013，26（6）：649-654.

［31］

马荣林，王尉平，蒋小岗，等.黄芩总黄酮对博莱霉素致大鼠肺纤维化的干预作用［J］.中国药理学通报，2011，27（4）：537-542.

［32］

LU J H，ZHONG Y Z，LIN Z C，et al. Baicalin alleviates radiation-induced epithelial-mesenchymal transition of primary type Ⅱ alveolar epithelial cells via TGF-β and ERK/GSK3β signaling pathways［J］. Biomed Pharmacother，2017，95：1219-1224.

［33］

张锐，沈雅芳，安肖霞，等.黄芩苷对博来霉素诱导肺纤维化小鼠的保护作用及其机制［J/OL］.中华危重症医学杂志（电子版），2020，13（1）：49-54.

［34］

ZHANG M J，ZHANG S. T cells in fibrosis and fibrotic diseases［J］. Front Immunol，2020，11：1142.

［35］

HUANG X Y，HE Y C，CHEN Y F，et al. Baicalin attenuates bleomycin-induced pulmonary fibrosis via adenosine A2a receptor related TGF-β1-induced ERK1/2 signaling pathway［J］. BMC Pulm Med，2016，16（1）：132.

［36］

万巧凤，顾立刚，李根茂，等.黄芩苷在流感病毒致肺纤维化早期进展中的作用机制［J］.中国药理学通报，2013，29（9）：1303-1307.

［37］

LIU T，DAI W J，LI C，et al. Baicalin alleviates silica-induced lung inflammation and fibrosis by inhibiting the Th17 response in C57BL/6 mice［J］. J Nat Prod，2015，78（12）：3049-3057.

［38］

曾珠，王飞，张巍，等.补阳还五汤联合黄芩素对肺纤维化大鼠炎性因子表达的影响研究［J］.中国临床药理学杂志，2020，36（1）：29-31，53.

［39］

徐明杭，蒙艳丽，王晓溪，等.黄芩苷对肺纤维化小鼠组织中纤维化因子TGF-β1及mmp2，timp2表达的影响［J］.中国中药杂志，2020，45（23）：5738-5744.

［40］

CHANG H，MENG H Y，BAI W F，et al. A metabolomic approach to elucidate the inhibitory effects of baicalin in pulmonary fibrosis［J］. Pharm Biol，2021，59（1）：1016-1025.

［41］

王清华，姚旭，魏新智，等.黄芩苷对肺纤维化大鼠肺组织氧化应激的反应及炎症细胞的影响［J］.中华中医药学刊，2017，35（6）：1382-1384.

［42］

王清华，姚旭，魏新智，等.黄芩苷抗博来霉素大鼠肺纤维化作用及机制研究［J］.长春中医药大学学报，2017，33（2）：192-194.

［43］

贾慧，陈晓玲，陈超，等.黄芩苷防止肺纤维化大鼠肺内结缔组织生长因子的上调［J］.生理学报，2010，62（6）：535-540.

［44］

刘威，陈晓玲，刘建辉，等.黄芩苷对博莱霉素诱导的肺纤维化的影响［J］.中国应用生理学杂志，2009，25（2）：145-149，289.

［45］

马文女，谷江叶，王迪，等.黄芩黄酮对矽肺小鼠脂质过氧化及纤维化损伤的影响［J］.承德医学院学报，2014，31（5）：445-446.

［46］

朱志农.黄芩苷对实验性肺纤维化大鼠肺组织TGF-β1 mRNA和蛋白表达的影响［J］.江西中医药，2010，41（7）：68-70.

［47］

颜双泉，陈璐，黄晶，等.缺氧在小鼠肺间质肌成纤维细胞化过程中的作用及黄芩苷的保护机制［J］.全科医学临床与教育，2021，19（5）：390-392，380.

［48］

PAROLA M，PINZANI M. Liver fibrosis：Pathophysiology，pathogenetic targets and clinical issues［J］. Mol Aspects Med，2019，65：37-55.

［49］

KISSELEVA T，BRENNER D. Molecular and cellular mechanisms of liver fibrosis and its regression［J］. Nat Rev Gastroenterol Hepatol，2021，18（3）：151-166.

［50］

FRIEDMAN S L，PINZANI M. Hepatic fibrosis 2022：Unmetneeds and a blueprint for the future［J］. Hepatology，2022，75（2）：473-488.

［51］

ROEHLEN N，CROUCHET E，BAUMERT T F. Liver fibrosis：mechanistic concepts and therapeutic perspectives［J］. Cells，2020，9（4）：875.

［52］

CABALLERÍA L，TORÁN P，CABALLERÍA J. Markers of hepatic fibrosis［J］. Med Clínica Engl Ed，2018，150（8）：310-316.

［53］

YANG X，LI Q，LIU W T，et al. Mesenchymal stromal cells in hepatic fibrosis/cirrhosis：from pathogenesis to treatment［J］. Cell Mol Immunol，2023，20（6）：583-599.

［54］

ZHANG M F，SERNA-SALASS，DAMBA T，et al. Hepatic stellate cell senescence in liver fibrosis：Characteristics，mechanisms and perspectives［J］. Mech Ageing Dev，2021，199：111572.

［55］

LUCANTONI F，MARTÍNEZ-CEREZUELA A，GRUEVSKA A，et al. Understanding the implication of autophagy in the activation of hepatic stellate cells in liver fibrosis：are we there yet？［J］. J Pathol，2021，254（3）：216-228.

［56］

陈卫卫.千层纸素A通过调控肝星状细胞自噬发挥抗肝纤维化的作用与机制研究［D］.南京：南京中医药大学，2018.

［57］

李敏，王斌，侯建平，等.柴胡、黄芩及其配伍抗大鼠肝纤维化作用研究［J］.天津中医药，2012，29（6）：576-578.

［58］

张敬博，陈平平，于栋华，等.黄芩-赤芍药对不同比例配伍抗大鼠肝纤维化模型作用机制探讨［J］.中国实验方剂学杂志，2022，28（12）：69-77.

［59］

SHIMIZU I. Sho-saiko-to：Japanese herbal medicine for protection against hepatic fibrosis and carcinoma［J］. J Gastroenterol Hepatol，2000，15 Suppl：D84-D90.

［60］

PAN T L，WANG P W，HUANG C H，et al. Herbal formula，Scutellariae Radix and Rhei rhizoma attenuate dimethylnitrosamine-induced liver fibrosis in a rat model［J］. Sci Rep，2015，5：11734.

［61］

孟洪宇，常虹.黄芩水煎液及黄芩苷抗大鼠肝纤维化药效作用比较研究［J］.世界中医药，2018，13（3）：699-702.

［62］

田华，王小平，陈瑜，等.黄芩素对大鼠肝纤维化保护作用的实验研究［J］.时珍国医国药，2016，27（9）：2305-2306.

［63］

刘国芳，袁思雨，李嘉豪，等.汉黄芩苷调控细胞因子信号转导抑制因子1对肝纤维化的作用［J］.医学研究生学报，2022，35（3）：236-244.

［64］

吴雄健.黄芩苷通过上调miR-3595靶向ACSL4表达抑制大鼠肝纤维化的机制研究［D］.广州：南方医科大学，2018.

［65］

ZHANG J L，ZHANG H M，DENG X L，et al. Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism，inflammation and fibrosis in mice［J］. Life Sci，2018，192：46-54.

［66］

JIANG X P，AI W B，WAN L Y，et al. The roles of microRNA families in hepatic fibrosis［J］. Cell Biosci，2017，7：34.

［67］

杨鹤梅，李素婷，梅立新，等.黄芩茎叶总黄酮对纤维化大鼠肝脏星形细胞活化的影响［J］.中国中医基础医学杂志，2006，12（1）：42-44.

［68］

刘志勇，叶军，薛东英.黄芩苷对肝纤维化大鼠相关细胞因子表达的影响［J］.中国当代医药，2013，20（12）：18-21.

［69］

程君，杨云霞.黄芩苷对四氯化碳致亚急性肝纤维化小鼠的保护作用［J］.华西药学杂志，2010，25（1）：32-33.

［70］

常虹，孟洪宇，王宇，等.基于尿液代谢组学的黄芩抗肝纤维化作用研究［J］.中国中药杂志，2018，43（10）：2140-2146.

［71］

张民，王德欣，赵吉光，等. MicroRNA-122介导黄芩苷对肝纤维化的保护作用的研究［Z］.2017.

［72］

刘世杰，姜宏齐，马英杰.黄芩苷通过抑制大鼠转化生长因子β1的表达发挥抗肝纤维化作用［J］.哈尔滨医科大学学报，2011，45（2）：128-130.

［73］

RAYEGO-MATEOS S，VALDIVIELSO J M. New therapeutic targets in chronic kidney disease progression and renal fibrosis［J］. Expert Opin Ther Targets，2020，24（7）：655-670.

［74］

WU R Y，LI J W，TU G W，et al. Comprehensive molecular and cellular characterization of acute kidney injury progression to renal fibrosis［J］. Front Immunol，2021，12：699192.

［75］

JING H，TANG S，LIN S，et al. Adiponectin in renal fibrosis［J］. Aging（Albany NY），2020，12（5）：4660-4672.

［76］

CHO M H. Renal fibrosis［J］. Korean J Pediatr，2010，53（7）：735-740.

［77］

HUMPHREYS B D. Mechanisms of renal fibrosis［J］. Annu Rev Physiol，2018，80：309-326.

［78］

NOGUEIRA A，PIRES M J，OLIVEIRA P A. Pathophysiological mechanisms of renal fibrosis：a review of animal models and therapeutic strategies［J］. In Vivo，2017，31（1）：1-22.

［79］

LIU F，ZHUANG S G. New therapies for the treatment of renal fibrosis［J］. Adv Exp Med Biol，2019，1165：625-659.

［80］

ZHANG Y Q，JIN D，KANG X M，et al. Signaling pathways involved in diabetic renal fibrosis［J］. Front Cell Dev Biol，2021，9：696542.

［81］

NAM J E，JO S Y，AHN C W，et al. Baicalin attenuates fibrogenic process in human renal proximal tubular cells（HK-2）exposed to diabetic milieu［J］. Life Sci，2020，254：117742.

［82］

ZHENG X P，NIE Q，FENG J，et al. Kidney-targeted baicalin-lysozyme conjugate ameliorates renal fibrosis in rats with diabetic nephropathy induced by streptozotocin［J］. BMC Nephrol，2020，21（1）：174.

［83］

马东红，郭明好，刘云.黄芩苷对UUO大鼠肾间质纤维化的影响及可能机制［J］.重庆医学，2017，46（17）：2323-2325，2329.

［84］

苗世环.黄芩素对大鼠肾间质纤维化内质网应激通路干预作用研究［D］.兰州：兰州大学，2017.

［85］

谢红东，杨珂，穆焕德，等.黄芩提取物对大鼠肾间质纤维化的作用及其抗氧化机制［J］.中国中西医结合肾病杂志，2009，10（3）：240-242，283.

［86］

郑智超.汉黄芩素对糖尿病肾病炎症和纤维化的改善作用及机制［D］.合肥：安徽医科大学，2020.

［87］

ISAKA Y. Targeting TGF-β signaling in kidney fibrosis［J］. Int J Mol Sci，2018，19（9）：2532.

［88］

HU Q，GAO L N，PENG B，et al. Baicalin and baicalein attenuate renal fibrosis in vitro via inhibition of the TGF-β1 signaling pathway［J］. Exp Ther Med，2017，14（4）：3074-3080.

［89］

ZHANG S F，XU L，LIANG R F，et al. Baicalin suppresses renal fibrosis through microRNA-124/TLR4/NF-κB axis in streptozotocin-induced diabetic nephropathy mice and high glucose-treated human proximal tubule epithelial cells［J］. J Physiol Biochem，2020，76（3）：407-416.

［90］

ZHOU S J，YIN X K，YUAN J，et al. Antifibrotic activities of scutellariae Radix extracts and flavonoids：comparative proteomics reveals distinct and shared mechanisms［J］. Phytomedicine，2022，100：154049.

［91］

谭禹洁，朱春玲，毛华雄.黄芩苷对单侧输尿管梗阻肾间质纤维化大鼠模型的治疗作用及机制研究［J］.中国当代儿科杂志，2016，18（4）：365-371.

［92］

ZHENG L，ZHANG C，LI L，et al. Baicalin ameliorates renal fibrosis via inhibition of transforming growth factor β1 production and downstream signal transduction［J］. Mol Med Rep，2017，15（4）：1702-1712.

［93］

王文玉，郭孜，孙淑军，等.黄芩素对大鼠肾间质纤维化的干预作用及对肾组织中TGF-β1和Smad-2表达的影响［J］.长春中医药大学学报，2012，28（3）：383-385.

［94］

WANG H，JIANG Q T，ZHANG L Z. Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway［J］. Pharm Biol，2022，60（1）：1407-1416.

［95］

SIDDARTH M，CHAWLA D，RAIZADA A，et al. Ameliorating effect of baicalin in cadmium induced kidney fibrosis［J］. Drug Metab Pharmacokinet，2019，34（1）：S18-S19.

［96］

郭明好，马东红，朱永俊，等.黄芩苷对结缔组织因子诱导肾小管上皮细胞转分化抑制作用的研究［Z］.2017.

［97］

FRANGOGIANNIS N G. Cardiac fibrosis［J］. Cardiovasc Res，2021，117（6）：1450-1488.

［98］

GONZÁLEZ A，SCHELBERT E B，DÍEZ J，et al. Myocardial interstitial fibrosis in heart failure：biological and translational perspectives［J］. J Am Coll Cardiol，2018，71（15）：1696-1706.

［99］

LÓPEZ B，RAVASSA S，MORENO M U，et al. Diffuse myocardial fibrosis：mechanisms，diagnosis and therapeutic approaches［J］. Nat Rev Cardiol，2021，18（7）：479-498.

［100］

JIANG W Y，XIONG Y Y，LI X S，et al. Cardiac fibrosis：cellular effectors，molecular pathways，and exosomal roles［J］. Front Cardiovasc Med，2021，8：715258.

［101］

ESPELAND T，LUNDE I G，H A B，et al. Myocardial fibrosis［J］. Tidsskr Nor Laegeforen，2018，138（16）：12.

［102］

KONG P，CHRISTIA P，FRANGOGIANNIS N G. The pathogenesis of cardiac fibrosis［J］. Cell Mol Life Sci，2014，71（4）：549-574.

［103］

张亚平，赵世明，任可可，等.黄芩苷对心肌梗死大鼠心肌纤维化的影响［J］.中西医结合心脑血管病杂志，2022，20（7）：1222-1227.

［104］

辛博. Nur77对心肌成纤维细胞功能影响及野黄芩苷调控Nur77抑制心肌纤维化相关研究［D］.上海：上海中医药大学，2019.

［105］

辛博，陈力，万丽丽，等.野黄芩苷对血管紧张素Ⅱ诱导小鼠心肌纤维化的影响［J］.中医药信息，2018，35（4）：4-8.

［106］

肖意川.黄芩苷调控AMPK/TGF-β/Smads信号通路抑制心肌纤维化机制研究［D］.广州：广州医科大学，2018.

［107］

KONG E K C，YU S，SANDERSON J E，et al. A novel anti-fibrotic agent，baicalein，for the treatment of myocardial fibrosis in spontaneously hypertensive rats［J］. Eur J Pharmacol，2011，658（2-3）：175-181.

［108］

SCHIRONE L，FORTE M，PALMERIO S，et al. A review of the molecular mechanisms underlying the development and progression of cardiac remodeling［J］. Oxid Med Cell Longev，2017，2017：3920195.

［109］

徐秋玲，郭冉，王以宁，等.黄芩苷抑制糖尿病大鼠心肌成纤维细胞分化机制研究［J］.中国当代医药，2022，29（16）：11-14.

［110］

KHAN S，ZHANG D L，ZHANG Y M，et al. Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties［J］. Mol Cell Endocrinol，2016，428：101-108.

［111］

ZHOU H，CHEN X，CHEN L Z，et al. Anti-fibrosis effect of scutellarin via inhibition of endothelial-mesenchymal transition on isoprenaline-induced myocardial fibrosis in rats［J］. Molecules，2014，19（10）：15611-15623.

［112］

徐秋玲，郑学芝，郭冉，等.黄芩苷抑制核因子κB信号通路对糖尿病鼠心肌保护机制研究［J］.现代医药卫生，2021，37（13）：2192-2195，2200.

［113］

KOTSIOU O S，GOURGOULIANIS K I，ZAROGIANNIS S G. IL-33/ST2 axis in organ fibrosis［J］. Front Immunol，2018，9：2432.

［114］

ROCKEY D C，DARW IN BELL P，HILL J A. Fibrosis—a common pathway to organ injury and failure［J］. N Engl J Med，2015，372（12）：1138-1149.

［115］

DEY A，VARELAS X，GUAN K L. Targeting the Hippo pathway in cancer，fibrosis，wound healing and regenerative medicine［J］. Nat Rev Drug Discov，2020，19（7）：480-494.

［116］

HANG P Z，GE F Q，LI P F，et al. The regulatory role of the BDNF/TrkB pathway in organ and tissue fibrosis［J］. Histol Histopathol，2021，36（11）：1133-1143.

［117］

CROFT A P，CAMPOS J，JANSEN K，et al. Distinct fibroblast subsets drive inflammation and damage in arthritis［J］. Nature，2019，570（7760）：246-251.

［118］

DRISKELL R R，LICHTENBERGER B M，HOSTE E，et al. Distinct fibroblast lineages determine dermal architecture in skin development and repair［J］. Nature，2013，504（7479）：277-281.

［119］

RODRIQUES S G，STICKELS R R，GOEVA A，et al. Slide-seq：a scalable technology for measuring genome-wide expression at high spatial resolution ［J］. Science，2019，363（6434）：1463-1467.

［120］

VICKOVIC S，ERASLAN G，SALMÉN F，et al. High-definition spatial transcriptomics for in situ tissue profiling［J］. Nat Methods，2019，16（10）：987-990.

［121］

REGEV A，TEICHMANN S A，LANDER E S，et al. The human cell atlas［J］. eLife，2017，6：e27041.

［122］

范建伟，许小凡，辛嘉萁，等.黄芩苷通过调控TGF-β1/TAK-NF-κB通路对胰腺纤维化的防治作用［J］.中国病理生理杂志，2020，36（2）：268-275.

［123］

胡小兰.黄芩苷对大鼠胰腺纤维化的保护作用［D］.武汉：湖北中医药大学，2010.

［124］

GANGULY R，GUPTA A，PANDEY A K. Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders：a review［J］. World J Gastroenterol，2022，28（26）：3047-3062.

［125］

CHANNE P，CHAVAN M，BHONDE R，et al. Antifibrotic effect of baicalin on arecoline induced human oral fibroblast：an in-vitro study［J］. Asian Pac J Cancer Prev，2024，25（4）：1349-1355.

［126］

XU H，ZHAO H F，DING C Y，et al. Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1［J］. Signal Transduct Target Ther，2023，8（1）：51.

［127］

ZOU Z Y，WEI J B，CHEN Y T，et al. FMRP phosphorylation modulates neuronal translation through YTHDF1［J］. Mol Cell，2023，83（23）：4304-4317.

［128］

TOROK N J，DRANOFF J A，SCHUPPAN D，et al. Strategies and endpoints of antifibrotic drug trials：Summary and recommendations from the AASLD Emerging Trends Conference，Chicago，June 2014［J］. Hepatology，2015，62（2）：627-634.

2026年第44卷第2期

PDF下载

引用本文

BibTeX

文章信息

doi: 10.13193/j.issn.1673-7717.2026.02.016

首发时间：2026-10-14
出版时间：2026-02-10

补充材料

相关文章

文章信息

作者

出版历史

基金

作者信息

成都中医药大学附属医院，四川成都 610072

参考文献

分享链接

https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.02.016

分享至

全文二维码

扫描看全文

引用本文

BibTeX

本文的引用情况

2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

关闭全屏

BibTeX
EndNote
RefWorks
TxT