Article(id=1317133155824423725, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.01.041, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791958615498, onlineDateStr=2026-10-14, pubDate=1767974400000, pubDateStr=2026-01-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791958615498, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791958615498, creator=13701087609, updateTime=1791958615498, updator=13701087609, issue=Issue{id=1317133098966433889, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='1', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1767974400000', pubDateStr='2026-01-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791958601943, creator='13701087609', updateTime=1791958824557, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317134032719171723, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317134032719171724, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=215, endPage=219, ext={EN=ArticleExt(id=1317133156537455407, articleId=1317133155824423725, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effects of Modified Wuling Powder（五苓散加味）Combined with TURP on Factors Related to Urodynamics and Tissue Pathological Reconstitution in BPH Patients, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effects of Modified Wuling Powder（五苓散加味）combined with transurethral resection of prostate（TURP）on factors related to urodynamics and tissue pathological reconstitution in patients with benign prostatic hyperplasia（BPH）.
Methods A total of 110 patients with BPH were treated in the hospital from June 2022 to August 2023，and were divided into the control group and the experimental group，with 55 cases in each group，using random number table method. The control group was treated with TURP，and the experimental group was treated with Modified Wuling Powder on the basis of TURP for a total of 4 weeks. The urodynamics，the factors related to tissue pathological reconstruction and traditional Chinese medicine syndrome scores of two groups before treatment and 4 weeks after treatment were compared，and the efficacy was evaluated 4 weeks after treatment and the occurrence of adverse reactions 4 weeks after surgery were compared.
Results Compared with those before treatment，after 4 weeks of treatment，the levels of slender urine dribbling，urethral astringency pain，frequent urinate，lower abdominal distension pain，dry stool，bitter mouth yellow score，maximumurination pressure（Pves），serum vascular endothelial growth factor（VEGF），transforming growth factor-β1（TGF-β1），connective tissue growth factor（CTGF）and fibronectin 1（FN1）in two groups decreased，and those in the experimental group were lower（P<0.05）. Compared with those before treatment，after 4 weeks of treatment，the bladder volume and maximum urinaryflow rate（Qmax）of the two groups increased，and they were higher in the experimental group（P<0.05）. The total effective rate of the experimental group was 74.07%（40/54），higher than that of the control group（90.38%，47/52）after 4 weeks of treatment（P<0.05）. Four weeks after surgery，there was no significant difference in the incidence of adverse reactions between the two groups［13.46%（7/52）vs 7.41%（4/54）］（P<0.05）.
Conclusion Modified Wuling Powder combined TURP can regulate the expressions of VEGF，TGF-β1，CTGF，FN1 and other factors related to tissue pathological reconstitution in BPH patients，improve the urodynamics，reduce the traditional Chinese medicine syndrome scores，and has accurate efficacy without increasing safety risk.
, authors=Ruiting CHEN, Yangyang BAI, Jianshe DONG, Jijian SUN, authorsList=Ruiting CHEN, Yangyang BAI, Jianshe DONG, Jijian SUN, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317133157367927600, articleId=1317133155824423725, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=五苓散加味联合经尿道前列腺电切术对良性前列腺增生尿动力学、组织病理性重建相关因子的影响, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 研究五苓散加味联合经尿道前列腺电切术（transurethral resection of prostate，TURP）对良性前列腺增生（benign prostatic hyperplasia，BPH）患者尿动力学、组织病理性重建相关因子的影响。
方法 纳入2022年6月—2023年8月于医院接受治疗的110例BPH患者，分为对照组与试验组，各55例，方法为随机数字表法。对照组予以TURP治疗，试验组在TURP的基础上予以五苓散加味治疗，共治疗4周。比较两组治疗前和治疗4周后尿动力学、组织病理性重建相关因子、中医证候积分，治疗4周后评价疗效，术后4周不良反应发生情况。
结果 较治疗前，治疗4周后两组尿线细长、尿滴沥、尿道涩痛、小便频繁、小腹胀痛、大便干燥、口苦苔黄评分，最大排尿压力（maximumurination pressure，Pves），血清血管内皮生长因子（vascular endothelial growth factor，VEGF）、转化生长因子-β1（transforming growth factor-β1，TGF-β1）、结缔组织生长因子（connective tissue growth factor，CTGF）和纤连蛋白1（fibronectin 1，FN1）水平降低，且试验组更低（P<0.05）。与治疗前比较，治疗4周后两组膀胱容量、最大尿流率（maximum urinaryflow rate，Qmax）升高，且试验组组间比较更高（P<0.05）。与对照组治疗4周后的总有效率（90.38%，47/52）比较，试验组总有效率（74.07%，40/54）更高（P<0.05）。术后4周，两组不良反应发生率比较［13.46%（7/52）vs 7.41%（4/54）］差异无统计学意义（P<0.05）。
结论 五苓散加味联合TURP可调节BPH患者VEGF、TGF-β1、CTGF、FN1等组织病理性重建相关因子表达，改善尿动力学，降低中医证候积分，疗效确切，并未增加安全风险。
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