中华中医药学刊

消风散合二妙散联合达克宁对霉菌性外耳道炎炎性因子及预后的影响

PDF下载

尹晋仙 ¹ , 郭莉 ² , 王世伟 ³

中华中医药学刊 | 省级项目平台 2026,44(1): 195-198

收起

中华中医药学刊 |省级项目平台 2026 , 44 (1) : 195 -198

消风散合二妙散联合达克宁对霉菌性外耳道炎炎性因子及预后的影响

全屏

[Author(id=1319724781218411317, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319724781369406263, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, authorId=1319724781218411317, language=EN, stringName=Jinxian YIN, firstName=Jinxian, middleName=null, lastName=YIN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Shengli Branch of Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan 030009, Shanxi, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319724783059710776, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, authorId=1319724781218411317, language=CN, stringName=尹晋仙, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.山西省中医院胜利分院，山西太原 030009, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319724779037373227, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, xref=1., ext=[AuthorCompanyExt(id=1319724779049956140, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, companyId=1319724779037373227, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Shengli Branch of Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan 030009, Shanxi, China), AuthorCompanyExt(id=1319724779058344749, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, companyId=1319724779037373227, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.山西省中医院胜利分院，山西太原 030009)])]), Author(id=1319724783147791162, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319724783290397500, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, authorId=1319724783147791162, language=EN, stringName=Li GUO, firstName=Li, middleName=null, lastName=GUO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.Changzhi Hospital of Traditional Chinese Medicine, Changzhi 046000, Shanxi, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319724783407838013, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, authorId=1319724783147791162, language=CN, stringName=郭莉, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.长治市中医医院，山西长治 046000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319724779142230830, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, xref=2., ext=[AuthorCompanyExt(id=1319724779150619439, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, companyId=1319724779142230830, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Changzhi Hospital of Traditional Chinese Medicine, Changzhi 046000, Shanxi, China), AuthorCompanyExt(id=1319724779159008048, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, companyId=1319724779142230830, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.长治市中医医院，山西长治 046000)])]), Author(id=1319724783500112703, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319724783588193089, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, authorId=1319724783500112703, language=EN, stringName=Shiwei WANG, firstName=Shiwei, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan 030012, Shanxi, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1319724783680467778, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, authorId=1319724783500112703, language=CN, stringName=王世伟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.山西省中医院，山西太原 030012, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1319724779251282737, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, xref=3., ext=[AuthorCompanyExt(id=1319724779259671346, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, companyId=1319724779251282737, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan 030012, Shanxi, China), AuthorCompanyExt(id=1319724779268059955, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133111872311767, companyId=1319724779251282737, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.山西省中医院，山西太原 030012)])])]

尹晋仙¹, 郭莉², 王世伟³

作者信息

^1.山西省中医院胜利分院，山西太原 030009

^2.长治市中医医院，山西长治 046000

^3.山西省中医院，山西太原 030012

Effects of Xiaofeng Powder（消风散），Ermiao Powder（二妙散）and Miconazole Nitrate on Inflammatory Factors and Prognosis in Patients with Mycotic External Otitis

Jinxian YIN¹, Li GUO², Shiwei WANG³

Affiliations

^1.Shengli Branch of Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan 030009, Shanxi, China

^2.Changzhi Hospital of Traditional Chinese Medicine, Changzhi 046000, Shanxi, China

^3.Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan 030012, Shanxi, China

出版时间: 2026-01-10 doi: 10.13193/j.issn.1673-7717.2026.01.037

文章导航

摘要

收起

目的

探究消风散合二妙散联合达克宁对霉菌性外耳道炎患者炎性因子及预后的影响。

方法

选取2021年8月—2023年8月医院98例霉菌性外耳道炎患者，采用随机数字表法分为两组，各49例。对照组予以达克宁治疗，研究组予以消风散合二妙散联合达克宁治疗，均持续治疗14 d。比较两组临床疗效、不良反应发生率及治疗前、治疗14 d后中医证候积分、听力水平［骨导听阈（bone conduction，BC）、气导听阈（air conduction，AC）、气骨导差（air bone gap，ABG）］、炎性因子［白细胞介素-2（interleukin-2，IL-2）、转化生长因子-β1（transforming growth factor-β1，TGF-β1）、白细胞介素-8（interleukin-8，IL-8）］，治疗后随访1个月、3个月，统计两组复发率。

结果

研究组治疗总有效率（91.84%，45/49）高于对照组（71.43%，35/49）（P<0.05）；研究组治疗14 d后耳痒、耳内闷胀、耳道流脓评分低于对照组（P<0.05）；研究组治疗14 d后血清IL-8、IL-2、TGF-β1水平低于对照组（P<0.05）；研究组治疗14 d后BC、AC、ABG值低于对照组（P<0.05）；研究组不良反应发生率（8.16%，4/49）与对照组（10.20%，5/49）比较，差异无统计学意义（P>0.05）；研究组随访期间复发率［0.00%（0/44）、4.55%（2/44）］与对照组［2.86%（1/35）、11.43%（4/35）］比较，差异无统计学意义（P>0.05）。

结论

采用消风散合二妙散联合达克宁治疗霉菌性外耳道炎患者的疗效显著，能有效下调炎性因子水平，改善患者临床症状及听力水平，且具有一定安全性。

关键词

霉菌性外耳道炎 / 消风散 / 二妙散 / 达克宁 / 听力水平 / 炎性因子 / 复发

Abstract

收起

Objective

To explore the effect of Xiaofeng Powder（消风散），Ermiao Powder（二妙散）and Miconazole Nitrate on inflammatory factors and prognosis in patients with mycotic external otitis.

Methods

From August 2021 to August 2023，98 patients with mycotic external otitis were selected and divided into two groups with random number table method，49 cases in each. The control group was treated with Miconazole Nitrate，and the research group was treated with Xiaofeng Powder and Ermiao Powder combined with Miconazole Nitrate for 14 days. The clinical efficacy，incidence of adverse reactions，TCM syndrome scores and hearing level［bone conduction threshold（BC），air conduction threshold（AC），air conduction difference（ABG）］，the levels of inflammatory factors［interleukin-2（IL-2），transforming growth factor-beta1（TGF-β1），interleukin-8（IL-8）］before and after 14 days of treatment were compared between the two groups. After followed up for 1 and 3 months after treatment，the recurrence rate of the two groups was counted.

Results

The total effective rate of treatment in the study group（91.84%，45/49）was higher than that in the control group（71.43%，35/49）（P<0.05）. The scores of ear itching，ear bloating and ear canal drainage in the study group were lower than those of the control group after 14 days of treatment（P<0.05）. After 14 days of treatment，the levels of serum IL-8，IL-2 and TGF-β1 in the study group were lower than those in the control group（P<0.05）. After 14 days of treatment，the values of BC，AC and ABG of the study group were lower than those of the control group（P<0.05）. Compared with that of the control group（10.20%，5/49），the incidence of adverse reactions in the study group（8.16%，4/49）was not statistically significant（P>0.05）. Compared with those of the control group［2.86%（1/35）、11.43%（4/35）］，the recurrence rates［0.00%（0/44）、4.55%（2/44）］of the study group during the follow-up were not statistically significant（P>0.05）.

Conclusion

Xiaofeng Powder combined with Ermiao Powder combined with Miconazole Nitrate has a significant effect on the treatment of patients with mycotic external otitis. It can effectively reduce the levels of inflammatory factors，improve the clinical symptoms and hearing level of patients，and has certain safety.

Key words

mycotic external otitis / Xiaofeng Powder（消风散） / Ermiao Powder（二妙散） / Miconazole Nitrate / hearing level / inflammatory factors / recurrence

引用本文

尹晋仙, 郭莉, 王世伟. 消风散合二妙散联合达克宁对霉菌性外耳道炎炎性因子及预后的影响. 中华中医药学刊, 2026 , 44 (1) : 195 -198 . DOI: 10.13193/j.issn.1673-7717.2026.01.037

Jinxian YIN, Li GUO, Shiwei WANG. Effects of Xiaofeng Powder（消风散），Ermiao Powder（二妙散）and Miconazole Nitrate on Inflammatory Factors and Prognosis in Patients with Mycotic External Otitis[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (1) : 195 -198 . DOI: 10.13193/j.issn.1673-7717.2026.01.037

参考文献

收起

文献

收起

参考文献引证文献

排序方式：

［1］

HASIBI M，ASHTIANI M K，MOTASSADI ZARANDI M，et al. A treatment protocol for management of bacterial and fungal malignant external otitis：a large cohort in Tehran，Iran［J］. Ann Otol Rhinol Laryngol，2017，126（7）：561-567.

［2］

徐平.曲安奈德益康唑乳膏联合活力碘治疗真菌性外耳道炎患者的临床效果观察［J］.现代诊断与治疗，2022，33（1）：4-6.

［3］

郭志鹏，闫国强，王中杰，等.内镜下外耳道冲洗联合派瑞松布药治疗霉菌性外耳道炎的临床疗效［J］.数理医药学杂志，2020，33（10）：1525-1526.

［4］

丛新.浅析耳内镜下外耳道清理联合抗真菌药物治疗霉菌性外耳道炎的临床效果［J］.中国现代药物应用，2019，13（2）：95-96.

［5］

齐伟平，冯亮，罗恬.通气散联合阿莫西林克拉维酸钾对急性化脓性中耳炎的疗效分析［J］.中国现代医学杂志，2019，29（20）：114-118.

［6］

聂玲娟，章灵群，李峰.消风散合二妙散加减联合硼酸酒精滴耳液治疗湿热侵耳型霉菌性外耳道炎30例［J］.浙江中医杂志，2018，53（9）：694.

［7］

杨雪.耳内镜下克霉唑软膏与制霉素粉治疗真菌性外耳道炎的效果［J］.哈尔滨医药，2023，43（6）：88-90.

［8］

黄德虎.耳内镜辅助下外耳道清理结合派瑞松乳膏治疗真菌性外耳道炎的疗效分析［J］.现代诊断与治疗，2023，34（13）：1938-1941.

［9］

SONG Y M，ABDELLA S，AFINJUOMO F，et al. Physicochemical properties of otic products for canine otitis externa：comparative analysis of marketed products［J］. BMC Vet Res，2023，19（1）：39.

［10］

王露.霉菌性外耳道炎患者接受耳内镜下外耳道冲洗联合酮康唑纱条治疗的临床效果［J］.当代医学，2022，28（3）：30-32.

［11］

DE SOUZA S，LAURINDO R，GUTFILEN-SCHLESINGER G，et al. The use of 99mTc-mononuclear leukocyte scintigraphy for necrotizing external otitis diagnosis［J］. Diagnostics，2023，13（3）：570.

［12］

王宗杰，于若卉，房庆鹏，等.中药醇提制剂联合达克宁乳膏治疗真菌性外耳道炎疗效观察［J］.现代中西医结合杂志，2021，30（33）：3727-3730.

［13］

韩金帅，赵竞一，王俊阁.托里消毒散口服联合耳净散喷敷治疗真菌性外耳道炎正虚邪恋证34例临床观察［J］.中医杂志，2021，62（1）：54-56，66.

［14］

毛春丽，郑其开，袁得材.自拟黄连汤联合耳内镜治疗真菌性外耳道炎的疗效观察［J］.中国中医药科技，2022，29（4）：649-650.

［15］

LEE J S，LEE S M，SON H S，et al. Analysis of the microbiome of the ear canal in normal individuals and patients with chronic otitis externa［J］. Ann Dermatol，2022，34（6）：461-471.

［16］

李玉彤，刘静淑，冯玉明，等.二妙散治疗湿热疑难病证的临床应用［J］.河北中医药学报，2022，37（4）：60-64.

［17］

杨蓦雷，唐玲，徐先发.耳内镜下双氧水冲洗联合曲安奈德益康唑治疗霉菌性外耳道炎的疗效及复发情况分析［J］.中国中西医结合耳鼻咽喉科杂志，2022，30（6）：412-415.

［18］

吴礽武.氟康唑注射液耳浴联合曲安奈德益康唑乳膏对真菌性外耳道炎疗效及血清TNF-α、CRP及IL-6影响［J］.药品评价，2023，20（4）：452-455.

［19］

LUCIANI L，STEFANETTI V，RAMPACCI E，et al. Comparison between clinical evaluations and laboratory findings and the impact of biofilm on antimicrobial susceptibility in vitro in canine otitis externa［J］. Vet Dermatol，2023，34（6）：586-596.

［20］

张凯，薛惠英，张雪芹. TGF-β1、MMP-3及Collagen Ⅲ在POP患者子宫主韧带组织中的表达及意义［J］.分子诊断与治疗杂志，2020，12（1）：39-43.

［21］

SEKAR R，RAJA K，GANESAN S，et al. Clinical and current microbiological profile with changing antibiotic sensitivity in malignant otitis externa［J］. Indian J Otolaryngol Head Neck Surg，2022，74（3）：4422-4427.

［22］

SJÖVALL A，PÄTÄRI-SAMPO A，SILVOLA J，et al. Acute otitis externa and auricular erysipelas；causative pathogens，antimicrobial susceptibility and treatment strategies of tertiary referral centre patients［J］. Eur J Clin Microbiol Infect Dis，2023，42（8）：1025-1029.

［23］

宋孝文，孟祥才，于鹏程，等.道地药材防风的质量成因分析［J］.特产研究，2024，46（2）：155-158.

［24］

NEMETH Z，VERGA E，VERDOLINI R. Topical treatment of eczematous external otitis involving the ear canal：long-term results of a trial comparing pimecrolimus 1 per cent versus clobetasone butyrate 0.05 per cent［J］. J Laryngol Otol，2022，136（7）：635-638.

［25］

易慧敏，陆韵薇，许孟秋，等.二妙散主要成分盐酸小檗碱与白术内酯Ⅲ对脂多糖诱导的BV2小胶质细胞炎性活化的影响［J］.现代中西医结合杂志，2021，30（30）：3328-3333，3348.

［26］

宋维维，袁冬兰，朱丹丹，等.基于网络药理学与分子对接探讨二妙散治疗宫颈人乳头瘤病毒感染的作用机制［J］.现代药物与临床，2023，38（11）：2706-2713.

［27］

LI Z L，LIU J，HAN H Q，et al. Chinese herbal formula ermiao powder（二妙散）regulates cholinergic anti-inflammatory pathway in rats with rheumatoid arthritis［J］. Chinese Journal of Integrative Medicine，2020，26（12）：905-912.

2026年第44卷第1期

PDF下载

引用本文

BibTeX

文章信息

doi: 10.13193/j.issn.1673-7717.2026.01.037

首发时间：2026-10-14
出版时间：2026-01-10

补充材料

相关文章

文章信息

作者

出版历史

基金

作者信息

^1.山西省中医院胜利分院，山西太原 030009

^2.长治市中医医院，山西长治 046000

^3.山西省中医院，山西太原 030012

参考文献

分享链接

https://castjournals.cast.org.cn/joweb/zhzyyxk/CN/10.13193/j.issn.1673-7717.2026.01.037

分享至

全文二维码

扫描看全文

引用本文

BibTeX

本文的引用情况

2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

关闭全屏

BibTeX
EndNote
RefWorks
TxT