Article(id=1317133165743948383, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.01.028, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791958617863, onlineDateStr=2026-10-14, pubDate=1767974400000, pubDateStr=2026-01-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791958617863, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791958617863, creator=13701087609, updateTime=1791958617863, updator=13701087609, issue=Issue{id=1317133098966433889, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='1', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1767974400000', pubDateStr='2026-01-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791958601943, creator='13701087609', updateTime=1791958824557, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317134032719171723, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317134032719171724, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=133, endPage=139, ext={EN=ArticleExt(id=1317133166146601568, articleId=1317133165743948383, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Study on Processing History，Chemical Composition and Pharmacological Effects of Longdan（Gentianae Radix et Rhizoma）, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

The processing of Longdan（Gentianae Radix et Rhizoma）has a long history. There have been processing methods such as net processing，cutting，stir-frying，ginger processing，wine processing and liquorice processing. The processing specifications and methods have been simplified with historical changes，and now ginger processing and licorice processing are no longer used. The chemical constituents of Longdan（Gentianae Radix et Rhizoma）mainly include iridoids，flavonoids，triterpenoids，alkaloids，volatile oils，polysaccharides and some trace elements. It has many biological activities such as anti-inflammatory and analgesic，anti-tumor，neuroprotection，liver protection，anti-oxidation，hypoglycemic and lipid-lowering effects. After the processing of Longdan（Gentianae Radix et Rhizoma），the structure of iridoid glycosides will undergo decarboxylation，oxidation，cyclization，evaporation and oxidation of volatile oil components，and the contents of some trace elements will change，thus changing its medicinal properties and enhancing its efficacy. After stir-frying，Longdan（Gentianae Radix et Rhizoma）can weaken the coldness，and wine-processed Longdan（Gentianae Radix et Rhizoma）can enhance the pharmacological activities such as liver protection. In this paper，the processing changes of ancient and modern Longdan（Gentianae Radix et Rhizoma）and the effects of different processed products on chemical constituents and pharmacological effects were studied in order to provide the help for the standardization of traditional Chinese medicine Longdan（Gentianae Radix et Rhizoma）.

, authors=Congcong QIN, Shimin ZHANG, Yuqing LI, authorsList=Congcong QIN, Shimin ZHANG, Yuqing LI, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317133167975318113, articleId=1317133165743948383, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=龙胆炮制历史沿革及化学成分、药理作用研究, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

龙胆炮制历史悠久，先后出现净制、切制、炒制、姜制、酒制、甘草制等炮制方法，其炮制规格和方法随历史变迁发生简化，现姜制、甘草制已不再采用。龙胆化学成分主要有环烯醚萜类、黄酮类、三萜类、生物碱类、挥发油类、多糖类及部分微量元素，具有抗炎镇痛、抗肿瘤、神经保护、保肝、抗氧化、降糖、降脂等多种生物活性。龙胆炮制后会使环烯醚萜苷类结构发生脱羧、氧化、环合，挥发油类成分出现蒸发、氧化等，部分微量元素成分含量发生变化，进而改变其药性，增强药效。龙胆炒制后可使寒性减弱，酒制龙胆能增强保肝等药理活性。研究古今龙胆的炮制变化及其不同炮制品对化学成分和药理作用的影响，以期为中药材龙胆的规范化研究提供帮助。

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