Article(id=1317133138359337393, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.01.019, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791958611334, onlineDateStr=2026-10-14, pubDate=1767974400000, pubDateStr=2026-01-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791958611334, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791958611334, creator=13701087609, updateTime=1791958611334, updator=13701087609, issue=Issue{id=1317133098966433889, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='1', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1767974400000', pubDateStr='2026-01-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791958601943, creator='13701087609', updateTime=1791958824557, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317134032719171723, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317134032719171724, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=89, endPage=92, ext={EN=ArticleExt(id=1317133138720047538, articleId=1317133138359337393, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Influence of Shenfu Injection（参附注射液）on Tissue Perfusion and Blood Oxygen Metabolism in Treatment of Septic Shock with Yang Qi Sudden Collapse Syndrome, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the effects of Shenfu Injection（参附注射液）on tissue perfusion and blood oxygen metabolism in the treatment of septic shock with Yang Qi sudden collapse syndrome.
Methods This study employed a retrospective case-control design to statistically analyze 92 cases of septic shock with Yang Qi sudden collapse syndrome treated in the Emergency Internal Medicine Observation Room and the Emergency Intensive Care Unit（EICU）of the Sixth People's Hospital affiliated with Shanghai Jiao Tong University School of Medicine from February 2023 to February 2024. The patients meeting the inclusion criteria were divided into a control group（46 cases treated with standard septic shock therapy）and the observation group（46 cases received standard septic shock therapy in conjunction with Shenfu Injection）. Hemodynamic indexes，lactic acid level and clearance，urine volume，acute physiology and chronic health evaluationⅡ（APACHEⅡ）and sequential organ failure assessment（SOFA）score were compared between the two groups.
Results After treatment，the values of mean arterial pressure（MAP），central venous pressure（CVP），central venous oxygen saturation（ScVO2），lactic acid clearance and urine volume of the observation group were higher than those of the control group，and lactic acid level was lower than control group（P<0.05）. The mechanical ventilation time，vasoactive drug use time and early goal-directed therapy（EGDT）compliance time in the observation group were lower than those in the control group，and the differences were significant（P<0.05）. After treatment，the levels of procalcitonin（PCT），C-reactive protein（CRP）and tumor necrosis factor-alpha（TNF-α）in the observation group were lower than those in the control group（P<0.05）. After treatment，APACHEⅡ scores and SOFA scores in the observation group were lower than those in the control group（P<0.05）.
Conclusion Shenfu Injection can effectively improve tissue perfusion level and blood oxygen metabolism，increase the lactate clearance rate，enhance the tissue circulation oxygen supply and blood circulation，correct shock faster and improve the prognosis of patients with septic shock.
, authors=Yiqing TONG, Yongxia LI, Qing XU, Lulu SHENG, Yuxin WANG, Qiming FENG, authorsList=Yiqing TONG, Yongxia LI, Qing XU, Lulu SHENG, Yuxin WANG, Qiming FENG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317133139265307059, articleId=1317133138359337393, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=参附注射液治疗阳气暴脱证型脓毒症休克对组织灌注、血氧代谢影响, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 探讨参附注射液治疗阳气暴脱证型脓毒症休克对组织灌注、血氧代谢的影响。
方法 采用回顾性病例对照研究，统计分析2023年2月—2024年2月于上海交通大学医学院附属第六人民医院急诊内科观察室以及急诊EICU就诊的92例阳气暴脱证型脓毒症休克患者作为研究对象，根据是否联合参附注射液治疗将符合标准的患者分为对照组46例（采用脓毒症休克常规治疗）和观察组46例（脓毒症休克常规治疗+参附注射液治疗），对比两组血流动力学指标、乳酸水平及清除率、尿量、急性生理和慢性健康状况（acute physiology and chronic health evaluation Ⅱ，APACHE Ⅱ）、序贯性器官衰竭（sequential organ failure assessment，SOFA）评分等。
结果 治疗后各时间点观察组平均动脉压（mean arterial pressure，MAP）、中心静脉压（central venous pressure，CVP）、中心静脉氧饱和度（central venous oxygen saturation，ScVO2）、乳酸清除率、尿量高于对照组，乳酸水平低于对照组（P<0.05）；观察组机械通气时间、血管活性药物使用时间及早期目标导向治疗（early goal-directed therapy，EGDT）达标时间均低于对照组，组间比较差异有统计学意义（P<0.05）；治疗后观察组降钙素原（procalcitonin，PCT）、C反应蛋白（c-reactive protein，CRP）、肿瘤坏死因子-α（tumor necrosis factor-alpha，TNF-α）水平均低于对照组（P<0.05）；治疗后观察组APACHEⅡ评分与SOFA评分低于对照组（P<0.05）。
结论 对阳气暴脱证型脓毒症休克患者应用参附注射液治疗可有效改善患者组织灌注水平及血氧代谢情况，提高乳酸清除率，增强组织循环氧供及血液循环，更快纠正休克，促使患者预后改善。
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