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Article(id=1317133138124460688, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.01.017, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791958611279, onlineDateStr=2026-10-14, pubDate=1767974400000, pubDateStr=2026-01-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791958611279, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791958611279, creator=13701087609, updateTime=1791958611279, updator=13701087609, issue=Issue{id=1317133098966433889, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='1', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1767974400000', pubDateStr='2026-01-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791958601943, creator='13701087609', updateTime=1791958824557, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317134032719171723, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317134032719171724, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=77, endPage=81, ext={EN=ArticleExt(id=1317133138346758801, articleId=1317133138124460688, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Synergistic Effect of Salted Processing on Efficacy of Dihuang（Rehmanniae Radix）in Cooling Blood and Stopping Bleeding, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective

To investigate the synergistic effect of salted processing on the efficacy of Dihuang（Rehmanniae Radix）in cooling blood and stopping bleeding.

Methods

On the basis of the preparation of Dihuang（Rehmanniae Radix）processed with salt，the reference method was used to replicate the mouse model of bleeding due to blood heat syndrome with 15 g·kg-1 of Zingiberis Rhizoma Decoction combined with 5% ethanol，and the synergistic effect of salted processing on the efficacy of Dihuang（Rehmanniae Radix）in cooling blood and stopping bleeding was comprehensively evaluated by the general signs of mice，anal temperature，water intake，bleeding time and thrombin time（TT），prothrombin time（PT），activated partial thromboplastin time（APTT）and fibrinogen（FIB）. The indicators such as the proportion of hot zone residence that can reflect temperature trend were detected and analyzed. Through principal component analysis of cooling blood and stopping bleeding effect and grey correlation analysis of the main quality control components，including the content of catalpol and digoxin D，as well as the temperature trend index reflecting the cold and heat medicinal properties，the synergistic effect of salt processing on the cooling blood and stopping bleeding effect was comprehensively evaluated.

Results

The model caused a significant decrease in the proportion of mice staying in the hot zone，an increase in water intake，as well as a significant prolongation or increase in anal temperature，bleeding time，PT，APTT，TT，FIB，Na+-K+-ATP and Ca2+-Mg2+-ATP（P<0.05 or P<0.01）. Low and high doses（3 and 6 g·kg-1）of Dihuang（Rehmanniae Radix）and its processed with salt products improved the abnormal indicators caused by the above model and the improvement effect of high dose was better than that of low dose（P<0.05 or P<0.01）. The improvement effect of Dihuang（Rehmanniae Radix）processed with salt on the above indicators was better than that of Dihuang（Rehmanniae Radix）under the same dose（P<0.05 or P<0.01）. The grey correlation coefficients of the main quality control components，catalpol and Rehmannioside D，for the components of cooling blood and stopping bleeding efficacy（PCA）- grey correlation（GCA）analyses were 0.818 and 0.676，as well as for the indices of cold and heat properties of the drug were 0.801 and 0.572，respectively.

Conclusion

Salted processing has the synergistic effect on cooling blood and stopping bleeding effect of Dihuang（Rehmanniae Radix），and to a certain extent，the synergistic effect may be related to the enhancement of the cold and heat properties，the contents of catalpol and Rehmannioside D of Dihuang（Rehmanniae Radix）by salted processing，with Rehmannioside D content contributing the most.

, authors=Yueyue ZHANG1, 2, Bingyu LONG1, Junming WANG1, 2, 3, 4, Qingwen HE1, Xiaohui WU1, 2, Lingling SONG1, Lijie JI1, Tianzhu ZHANG1, authorsList=Yueyue ZHANG, Bingyu LONG, Junming WANG, Qingwen HE, Xiaohui WU, Lingling SONG, Lijie JI, Tianzhu ZHANG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317133138766189202, articleId=1317133138124460688, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=盐制炮制对地黄凉血止血功效的增效作用探索, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的

探索盐制炮制对地黄凉血止血功效的增效作用。

方法

在制备盐制地黄炮制品基础上，参考文献方法以干姜水煎液15 g·kg-1联合5%乙醇复制小鼠血热出血模型，通过对小鼠一般体征、肛温、饮水量、出血时间、血浆凝血酶时间（TT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原含量（FIB）以及对能够反映温度趋向性的热区停留比例等指标的检测分析，并通过对凉血止血功效的主成分分析和功效主成分分别与主要质控成分梓醇和地黄苷D的含量以及反映寒热药性的温度趋向性指标的灰色关联分析，综合评价盐制炮制对地黄凉血止血功效的增效作用。

结果

模型引起了小鼠在热区停留比例显著降低、饮水量增加以及肛温、出血时间、PT、APTT、TT、FIB、Na+-K+-ATP、Ca2+-Mg2+-ATP均显著延长或升高（P<0.05或P<0.01）；地黄生品及其盐制品低、高剂量（3、6 g·kg-1）对上述模型引起的指标异常均具有改善作用，且高剂量的改善作用优于低剂量（P<0.05或P<0.01）；地黄盐制品对上述指标的改善作用优于同剂量下的地黄生品（P<0.05或P<0.01）。主要质控成分梓醇和地黄苷D对凉血止血功效成分（PCA）-灰色关联（GCA）分析的灰色关联系数分别为0.818和0.676，以及对寒热药性指标的灰色关联系数分别为0.801和0.572。

结论

盐制炮制对地黄凉血止血功效具有增效作用，在一定程度上该炮制增效作用可能与盐制增强地黄的寒性药性、梓醇和地黄苷D含量有关，其中地黄苷D含量贡献最大。

, authors=张月月1, 2, 龙冰玉1, 王君明1, 2, 3, 4, 何庆文1, 巫晓慧1, 2, 宋玲玲1, 纪丽婕1, 张天柱1, authorsList=张月月, 龙冰玉, 王君明, 何庆文, 巫晓慧, 宋玲玲, 纪丽婕, 张天柱, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=VPiFDKP3VUCTMCUqboF2xQ==, magXml=EfrdkolA5RgqQtzJIy5L+A==, pdfUrl=null, pdf=Oh1RoAe3B3omIWMu4XDmiw==, pdfFileSize=1709734, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=u4hZiEaFY7DNjegkpxmUag==, mapNumber=null, fund=null)}, authors=[Author(id=1319724634510053394, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133138124460688, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1319724634614910997, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1317133138124460688, authorId=1319724634510053394, language=EN, stringName=Yueyue ZHANG, firstName=Yueyue, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1.College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China
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2.Zhengzhou Engineering Research Center for Safety and Efficacy Enhancement of Chinese Materia Medica, Zhengzhou 450046, Henan, China
3.Collaborative Innovation Center for Research and Development on the Whole Industry China of Yu-Yao, Zhengzhou 450046, Henan, China
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2.郑州市中药安全与功效提升工程研究中心，河南郑州 450046
3.豫药全产业链研发河南省协同创新中心，河南郑州 450046
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盐制炮制对地黄凉血止血功效的增效作用探索
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张月月 1, 2 , 龙冰玉 1 , 王君明 1, 2, 3, 4 , 何庆文 1 , 巫晓慧 1, 2 , 宋玲玲 1 , 纪丽婕 1 , 张天柱 1
中华中医药学刊 | 国家项目点击 2026,44(1): 77-81
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中华中医药学刊 |国家项目点击 2026 , 44 (1) : 77 -81
盐制炮制对地黄凉血止血功效的增效作用探索
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张月月1, 2, 龙冰玉1, 王君明1, 2, 3, 4, 何庆文1, 巫晓慧1, 2, 宋玲玲1, 纪丽婕1, 张天柱1
作者信息
  • 1.河南中医药大学药学院，河南郑州 450046
  • 2.郑州市中药安全与功效提升工程研究中心，河南郑州 450046
  • 3.豫药全产业链研发河南省协同创新中心，河南郑州 450046
  • 4.呼吸疾病中医药防治省部共建协同创新中心，河南郑州 450046
Synergistic Effect of Salted Processing on Efficacy of Dihuang（Rehmanniae Radix）in Cooling Blood and Stopping Bleeding
Yueyue ZHANG1, 2, Bingyu LONG1, Junming WANG1, 2, 3, 4, Qingwen HE1, Xiaohui WU1, 2, Lingling SONG1, Lijie JI1, Tianzhu ZHANG1
Affiliations
  • 1.College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China
  • 2.Zhengzhou Engineering Research Center for Safety and Efficacy Enhancement of Chinese Materia Medica, Zhengzhou 450046, Henan, China
  • 3.Collaborative Innovation Center for Research and Development on the Whole Industry China of Yu-Yao, Zhengzhou 450046, Henan, China
  • 4.Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P. R. China, Zhengzhou 450046, Henan, China
出版时间: 2026-01-10 doi: 10.13193/j.issn.1673-7717.2026.01.017
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摘要
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目的

探索盐制炮制对地黄凉血止血功效的增效作用。

方法

在制备盐制地黄炮制品基础上，参考文献方法以干姜水煎液15 g·kg-1联合5%乙醇复制小鼠血热出血模型，通过对小鼠一般体征、肛温、饮水量、出血时间、血浆凝血酶时间（TT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原含量（FIB）以及对能够反映温度趋向性的热区停留比例等指标的检测分析，并通过对凉血止血功效的主成分分析和功效主成分分别与主要质控成分梓醇和地黄苷D的含量以及反映寒热药性的温度趋向性指标的灰色关联分析，综合评价盐制炮制对地黄凉血止血功效的增效作用。

结果

模型引起了小鼠在热区停留比例显著降低、饮水量增加以及肛温、出血时间、PT、APTT、TT、FIB、Na+-K+-ATP、Ca2+-Mg2+-ATP均显著延长或升高（P<0.05或P<0.01）；地黄生品及其盐制品低、高剂量（3、6 g·kg-1）对上述模型引起的指标异常均具有改善作用，且高剂量的改善作用优于低剂量（P<0.05或P<0.01）；地黄盐制品对上述指标的改善作用优于同剂量下的地黄生品（P<0.05或P<0.01）。主要质控成分梓醇和地黄苷D对凉血止血功效成分（PCA）-灰色关联（GCA）分析的灰色关联系数分别为0.818和0.676，以及对寒热药性指标的灰色关联系数分别为0.801和0.572。

结论

盐制炮制对地黄凉血止血功效具有增效作用，在一定程度上该炮制增效作用可能与盐制增强地黄的寒性药性、梓醇和地黄苷D含量有关，其中地黄苷D含量贡献最大。

盐制地黄  /  凉血止血功效  /  炮制增效  /  寒性药性  /  主成分-灰色关联分析
Objective

To investigate the synergistic effect of salted processing on the efficacy of Dihuang（Rehmanniae Radix）in cooling blood and stopping bleeding.

Methods

On the basis of the preparation of Dihuang（Rehmanniae Radix）processed with salt，the reference method was used to replicate the mouse model of bleeding due to blood heat syndrome with 15 g·kg-1 of Zingiberis Rhizoma Decoction combined with 5% ethanol，and the synergistic effect of salted processing on the efficacy of Dihuang（Rehmanniae Radix）in cooling blood and stopping bleeding was comprehensively evaluated by the general signs of mice，anal temperature，water intake，bleeding time and thrombin time（TT），prothrombin time（PT），activated partial thromboplastin time（APTT）and fibrinogen（FIB）. The indicators such as the proportion of hot zone residence that can reflect temperature trend were detected and analyzed. Through principal component analysis of cooling blood and stopping bleeding effect and grey correlation analysis of the main quality control components，including the content of catalpol and digoxin D，as well as the temperature trend index reflecting the cold and heat medicinal properties，the synergistic effect of salt processing on the cooling blood and stopping bleeding effect was comprehensively evaluated.

Results

The model caused a significant decrease in the proportion of mice staying in the hot zone，an increase in water intake，as well as a significant prolongation or increase in anal temperature，bleeding time，PT，APTT，TT，FIB，Na+-K+-ATP and Ca2+-Mg2+-ATP（P<0.05 or P<0.01）. Low and high doses（3 and 6 g·kg-1）of Dihuang（Rehmanniae Radix）and its processed with salt products improved the abnormal indicators caused by the above model and the improvement effect of high dose was better than that of low dose（P<0.05 or P<0.01）. The improvement effect of Dihuang（Rehmanniae Radix）processed with salt on the above indicators was better than that of Dihuang（Rehmanniae Radix）under the same dose（P<0.05 or P<0.01）. The grey correlation coefficients of the main quality control components，catalpol and Rehmannioside D，for the components of cooling blood and stopping bleeding efficacy（PCA）- grey correlation（GCA）analyses were 0.818 and 0.676，as well as for the indices of cold and heat properties of the drug were 0.801 and 0.572，respectively.

Conclusion

Salted processing has the synergistic effect on cooling blood and stopping bleeding effect of Dihuang（Rehmanniae Radix），and to a certain extent，the synergistic effect may be related to the enhancement of the cold and heat properties，the contents of catalpol and Rehmannioside D of Dihuang（Rehmanniae Radix）by salted processing，with Rehmannioside D content contributing the most.

Dihuang（Rehmanniae Radix）processed with salt  /  cooling blood and stopping bleeding effect  /  increasing effect after processing  /  cold medicinal properties  /  principal component-grey correlation analysis
张月月, 龙冰玉, 王君明, 何庆文, 巫晓慧, 宋玲玲, 纪丽婕, 张天柱. 盐制炮制对地黄凉血止血功效的增效作用探索. 中华中医药学刊, 2026 , 44 (1) : 77 -81 . DOI: 10.13193/j.issn.1673-7717.2026.01.017
Yueyue ZHANG, Bingyu LONG, Junming WANG, Qingwen HE, Xiaohui WU, Lingling SONG, Lijie JI, Tianzhu ZHANG. Synergistic Effect of Salted Processing on Efficacy of Dihuang（Rehmanniae Radix）in Cooling Blood and Stopping Bleeding[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (1) : 77 -81 . DOI: 10.13193/j.issn.1673-7717.2026.01.017

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2026年第44卷第1期
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doi: 10.13193/j.issn.1673-7717.2026.01.017
  • 首发时间：2026-10-14
  • 出版时间：2026-01-10
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    1.河南中医药大学药学院，河南郑州 450046
    2.郑州市中药安全与功效提升工程研究中心，河南郑州 450046
    3.豫药全产业链研发河南省协同创新中心，河南郑州 450046
    4.呼吸疾病中医药防治省部共建协同创新中心，河南郑州 450046
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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