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Article(id=1317133125747065148, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2026.01.015, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791958608327, onlineDateStr=2026-10-14, pubDate=1767974400000, pubDateStr=2026-01-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791958608327, onlineIssueDateStr=2026-10-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791958608327, creator=13701087609, updateTime=1791958608327, updator=13701087609, issue=Issue{id=1317133098966433889, tenantId=1146029695717560320, journalId=1255847919539208197, year='2026', volume='44', issue='1', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1767974400000', pubDateStr='2026-01-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791958601943, creator='13701087609', updateTime=1791958824557, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317134032719171723, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317134032719171724, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1317133098966433889, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=67, endPage=71, ext={EN=ArticleExt(id=1317133125927420221, articleId=1317133125747065148, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Randomized Controlled Trial of Effect of Buzhong Yiqi Decoction（补中益气汤）Combined with TPO-RA on Chemotherapy Induced Thrombocytopenia（Qi and Blood Deficiency Syndrome）, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective

To investigate the clinical efficacy of Buzhong Yiqi Decoction（补中益气汤，BZYQT）combined with thrombopoietin receptor agonists（TPO-RA）in treating thrombocytopenia caused by tumor therapy.

Methods

A total of 160 patients with thrombocytopenia due to tumor therapy were randomly divided into a control group and an experimental group，each consisting of 80 cases. The control group was only given TPO-RA treatment，while the experimental group received BZYQT in combination with TPO-RA. After 8 weeks，the two groups were compared in terms of platelet count，bleeding risk level，Karnofsky performance status（KPS）score，changes in serum thrombopoietin（TPO）content and adverse reactions.

Results

After treatment，both groups showed significant recovery in platelet parameters，bleeding risk，KPS score and serum TPO content. Compared with that of the control group，the overall effectiveness rate of the treatment group reached 95.00%（76/80）. Additionally，the values of platelet count（PLT）and plateletcrit（PCT）of the experimental group were higher than those of the control group（P<0.001），while the values of platelet distribution width（PDW）and mean platelet volume（MPV）were lower（P<0.001）. The improvement in bleeding risk and KPS score was more pronounced in the experimental group than that in the control group（P<0.001）. The serum TPO content in the experimental group was significantly higher than that in the control group（P<0.001），and the number of adverse reaction events decreased.

Conclusion

The combination of BZYQT and TPO-RA in treating thrombocytopenia caused by tumor therapy yields more significant effects and can reduce the adverse reactions caused by TPO-RA to a certain extent.

, authors=Minghu DU1, Jianxia HUANG1, Yupei WANG1, Yuqing DONG1, Wanqi GAO1, Yan WANG1, Qing WU1, Binzhang WU1, Chunmei MA2, authorsList=Minghu DU, Jianxia HUANG, Yupei WANG, Yuqing DONG, Wanqi GAO, Yan WANG, Qing WU, Binzhang WU, Chunmei MA, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317133126137135422, articleId=1317133125747065148, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=补中益气汤联合TPO-RA对肿瘤治疗所致血小板减少症（气血不足证）作用的随机对照试验, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的

观察补中益气汤联合血小板生成素受体激动剂（Thrombopoietin Receptor Agonists，TPO-RA）对肿瘤治疗所致血小板减少症（气血不足证）的临床疗效。

方法

将160例肿瘤治疗所致血小板减少症患者按照随机分组的方式分为对照组和治疗组，各80例，对照组只给予TPO-RA治疗，治疗组给予补中益气汤联合TPO-RA进行治疗，8周后比较两组患者血小板计数、出血风险等级比较、卡氏功能状态量表（Karnofsky Performance Status，KPS）评分、血清血小板生成素（Thrombopoietin，TPO）含量变化及不良反应情况。

结果

经过治疗后，各组患者的血小板参数、出血风险、KPS评分、血清TPO含量等均有明显恢复。与对照组相比，治疗组总有效率达到95.00%（76/80），且治疗组患者的血小板计数（Platelet Count，PLT）、血小板压积（Plateletcrit，PCT）高于对照组（P<0.001），血小板分布宽度（Platelet Distribution Width，PDW）、血小板平均体积（Mean Platelet Volume，MPV）均低于对照组（P<0.001），治疗组患者的出血风险及KPS评分改善较对照组更加明显（P<0.001），治疗组患者血清TPO含量较对照组明显升高（P<0.001），且不良反应事件数量下降。

结论

补中益气汤联合TPO-RA治疗肿瘤治疗所致血小板减少症疗效更加显著，并能够一定程度上减少TPO-RA导致的不良反应。

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补中益气汤联合TPO-RA对肿瘤治疗所致血小板减少症（气血不足证）作用的随机对照试验
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杜明虎 1 , 黄建霞 1 , 王玉珮 1 , 董玉青 1 , 高万琦 1 , 王燕 1 , 吴庆 1 , 吴彬章 1 , 马春梅 2
中华中医药学刊 | 国家项目点击 2026,44(1): 67-71
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中华中医药学刊 |国家项目点击 2026 , 44 (1) : 67 -71
补中益气汤联合TPO-RA对肿瘤治疗所致血小板减少症（气血不足证）作用的随机对照试验
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杜明虎1, 黄建霞1, 王玉珮1, 董玉青1, 高万琦1, 王燕1, 吴庆1, 吴彬章1, 马春梅2
作者信息
  • 1.武威市人民医院，甘肃武威 733000
  • 2.民勤县疾病预防控制中心，甘肃民勤 733300
Randomized Controlled Trial of Effect of Buzhong Yiqi Decoction（补中益气汤）Combined with TPO-RA on Chemotherapy Induced Thrombocytopenia（Qi and Blood Deficiency Syndrome）
Minghu DU1, Jianxia HUANG1, Yupei WANG1, Yuqing DONG1, Wanqi GAO1, Yan WANG1, Qing WU1, Binzhang WU1, Chunmei MA2
Affiliations
  • 1.Wuwei People's Hospital, Wuwei 733000, Gansu, China
  • 2.The Center for Disease Control and Prevention of Minqin County, Minqin 733300, Gansu, China
出版时间: 2026-01-10 doi: 10.13193/j.issn.1673-7717.2026.01.015
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摘要
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目的

观察补中益气汤联合血小板生成素受体激动剂（Thrombopoietin Receptor Agonists，TPO-RA）对肿瘤治疗所致血小板减少症（气血不足证）的临床疗效。

方法

将160例肿瘤治疗所致血小板减少症患者按照随机分组的方式分为对照组和治疗组，各80例，对照组只给予TPO-RA治疗，治疗组给予补中益气汤联合TPO-RA进行治疗，8周后比较两组患者血小板计数、出血风险等级比较、卡氏功能状态量表（Karnofsky Performance Status，KPS）评分、血清血小板生成素（Thrombopoietin，TPO）含量变化及不良反应情况。

结果

经过治疗后，各组患者的血小板参数、出血风险、KPS评分、血清TPO含量等均有明显恢复。与对照组相比，治疗组总有效率达到95.00%（76/80），且治疗组患者的血小板计数（Platelet Count，PLT）、血小板压积（Plateletcrit，PCT）高于对照组（P<0.001），血小板分布宽度（Platelet Distribution Width，PDW）、血小板平均体积（Mean Platelet Volume，MPV）均低于对照组（P<0.001），治疗组患者的出血风险及KPS评分改善较对照组更加明显（P<0.001），治疗组患者血清TPO含量较对照组明显升高（P<0.001），且不良反应事件数量下降。

结论

补中益气汤联合TPO-RA治疗肿瘤治疗所致血小板减少症疗效更加显著，并能够一定程度上减少TPO-RA导致的不良反应。

补中益气汤  /  TPO-RA  /  肿瘤治疗所致血小板减少症  /  随机对照试验
Objective

To investigate the clinical efficacy of Buzhong Yiqi Decoction（补中益气汤，BZYQT）combined with thrombopoietin receptor agonists（TPO-RA）in treating thrombocytopenia caused by tumor therapy.

Methods

A total of 160 patients with thrombocytopenia due to tumor therapy were randomly divided into a control group and an experimental group，each consisting of 80 cases. The control group was only given TPO-RA treatment，while the experimental group received BZYQT in combination with TPO-RA. After 8 weeks，the two groups were compared in terms of platelet count，bleeding risk level，Karnofsky performance status（KPS）score，changes in serum thrombopoietin（TPO）content and adverse reactions.

Results

After treatment，both groups showed significant recovery in platelet parameters，bleeding risk，KPS score and serum TPO content. Compared with that of the control group，the overall effectiveness rate of the treatment group reached 95.00%（76/80）. Additionally，the values of platelet count（PLT）and plateletcrit（PCT）of the experimental group were higher than those of the control group（P<0.001），while the values of platelet distribution width（PDW）and mean platelet volume（MPV）were lower（P<0.001）. The improvement in bleeding risk and KPS score was more pronounced in the experimental group than that in the control group（P<0.001）. The serum TPO content in the experimental group was significantly higher than that in the control group（P<0.001），and the number of adverse reaction events decreased.

Conclusion

The combination of BZYQT and TPO-RA in treating thrombocytopenia caused by tumor therapy yields more significant effects and can reduce the adverse reactions caused by TPO-RA to a certain extent.

Buzhong Yiqi Decoction（补中益气汤）  /  TPO-RA  /  thrombocytopenia caused by tumor therapy  /  randomized controlled trial
杜明虎, 黄建霞, 王玉珮, 董玉青, 高万琦, 王燕, 吴庆, 吴彬章, 马春梅. 补中益气汤联合TPO-RA对肿瘤治疗所致血小板减少症（气血不足证）作用的随机对照试验. 中华中医药学刊, 2026 , 44 (1) : 67 -71 . DOI: 10.13193/j.issn.1673-7717.2026.01.015
Minghu DU, Jianxia HUANG, Yupei WANG, Yuqing DONG, Wanqi GAO, Yan WANG, Qing WU, Binzhang WU, Chunmei MA. Randomized Controlled Trial of Effect of Buzhong Yiqi Decoction（补中益气汤）Combined with TPO-RA on Chemotherapy Induced Thrombocytopenia（Qi and Blood Deficiency Syndrome）[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (1) : 67 -71 . DOI: 10.13193/j.issn.1673-7717.2026.01.015

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doi: 10.13193/j.issn.1673-7717.2026.01.015
  • 首发时间：2026-10-14
  • 出版时间：2026-01-10
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    1.武威市人民医院，甘肃武威 733000
    2.民勤县疾病预防控制中心，甘肃民勤 733300
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
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