Article(id=1322927067779703287, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926985957221241, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.11.043, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339991754, onlineDateStr=2026-10-30, pubDate=1762704000000, pubDateStr=2025-11-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339991754, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339991754, creator=13701087609, updateTime=1793339991754, updator=13701087609, issue=Issue{id=1322926985957221241, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='11', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1762704000000', pubDateStr='2025-11-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339972247, creator='13701087609', updateTime=1793340743335, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322930220201804556, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926985957221241, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322930220201804557, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926985957221241, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=213, endPage=216, ext={EN=ArticleExt(id=1322927068085887480, articleId=1322927067779703287, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Clinical Observation of Anshen Jiaotai Yizhi Decoction（安神交泰益智汤）in Treatment of Parkinson's Disease with Sleep Disorders and Its Effect on Hcy and IL-1β Levels in Patients, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To study the clinical effect of Anshen Jiaotai Yizhi Decoction（安神交泰益智汤）in the treatment of Parkinson's disease with sleep disorders and its effect on the levels of homocysteine（Hcy）and interleukin-1β（IL-1β）in patients.
Methods 110 patients with Parkinson's disease and sleep disorders were selected and divided into two groups，55 patients in the control group were treated with western medicine，and 55 patients in the observation group were treated with western medicine combined with Anshen Jiaotai Yizhi Decoction. After 2 weeks of treatment，the clinical efficacy，sleep quality，sleep structure index，related factor levels and adverse reactions were compared.
Results The total effective rate of the observation group（96.36%，53/55）was higher than that（83.64%，46/55）of the control group（P<0.05）. The Epworth sleepiness scale（ESS）scores after 2 weeks of treatment of the observation group was（7.92±1.83）points，and that of the control group was（9.14±2.11）points（P<0.05）. The sleep efficiency of the two groups increased，the sleep latency shortened，the number of awakenings decreased，the apnea hypopnea index（AHI）decreased，and the minimum oxygen saturation increased. The indexes of the observation group were significantly better than those of the control group［（78.89±6.20）%，（23.10±4.08）min，（1.97±0.56）times，（9.08±1.03），（89.15±5.80）% vs（73.39±6.14）%，（27.82±5.26）min，（2.75±0.67）times，（11.71±1.34），（86.30±5.52）%］（P<0.05）. The levels of serum Hcy and IL-1βin the two groups decreased，and the levels of the observation group were significantly lower than those in the control group［（1.01±0.06）mg/L，（8.90±1.85）pg/mL vs（1.20±0.06）mg/L，（10.13±1.91）pg/mL］（P<0.05）. The incidence of adverse reactions of the two groups had no significance（14.55%，8/55 vs 10.91%，6/55）（P>0.05）.
Conclusion Anshen Jiaotai Yizhi Decoction has a better clinical effect in the treatment of Parkinson's disease with sleep disorders. It can significantly improve sleep status and regulate the neuroimmune inflammatory response in the brain. It is a safe and effective treatment plan and is worthy of application.
, authors=Lidan PU, Yawei ZHAO, Lihong CAO, Haolei YANG, Ziwei YUAN, Lijing YANG, authorsList=Lidan PU, Yawei ZHAO, Lihong CAO, Haolei YANG, Ziwei YUAN, Lijing YANG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322927069239321087, articleId=1322927067779703287, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=安神交泰益智汤治疗帕金森病睡眠障碍临床效果及对患者同型半胱氨酸、白细胞介素-1β水平影响, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 研究安神交泰益智汤治疗帕金森病睡眠障碍临床效果及对患者同型半胱氨酸（Homocysteine，Hcy）、白细胞介素-1β（Interleukin—1β，IL-1β）水平影响。
方法 选取帕金森病合并睡眠障碍患者110例，按照随机数字表法均分为两组。对照组55例进行西医治疗，观察组55例采用西医联合安神交泰益智汤治疗，治疗2周后比较两组患者的临床疗效、睡眠质量、睡眠结构指标、相关因子水平及不良反应。
结果 观察组总有效率96.36%（53/55），高于对照组的83.64%（46/55）（P<0.05）。爱泼沃斯嗜睡量表（Epworth sleepiness scale，ESS）评分：治疗2周后观察组（7.92±1.83）分显著低于对照组（9.14±2.11）分（P<0.05）。治疗前两组睡眠结构各指标差异均无统计学意义（P>0.05），治疗2周后观察组睡眠效率、睡眠潜伏期、觉醒次数、呼吸暂停低通气指数（Apnea-hypopnea index，AHI）、最低氧饱和度显著优于对照组［（78.89±6.20）%、（23.10±4.08）min、（1.97±0.56）次、（9.08±1.03）、（89.15±5.80）% vs（73.39±6.14）%、（27.82±5.26）min、（2.75±0.67）次、（11.71±1.34）、（86.30±5.52）%］（P<0.05）。治疗前两组血清Hcy、IL-1β可比（P>0.05），治疗2周后观察组低于对照组［（1.01±0.06）mg/L、（8.90±1.85）pg/mL vs（1.20±0.06）mg/L、（10.13±1.91）pg/mL］（P<0.05）。观察组、对照组不良反应发生率分别为14.55%（8/55）、10.91%（6/55），差异无统计学意义（P>0.05）。
结论 安神交泰益智汤治疗帕金森病睡眠障碍临床效果更佳，能够显著改善睡眠状态、调节脑内神经免疫炎症反应，是安全有效的治疗方案，值得应用。
, authors=蒲俪丹, 赵亚伟, 曹利红, 杨浩雷, 袁子薇, 杨丽静, authorsList=蒲俪丹, 赵亚伟, 曹利红, 杨浩雷, 袁子薇, 杨丽静, authorCompany=null, correspAuthors=null, authorNote=
蒲俪丹（1988-），女，河北无极人，主治医师，硕士，研究方向：中西医结合脑病、呼吸睡眠疾病的治疗。
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蒲俪丹（1988-），女，河北无极人，主治医师，硕士，研究方向：中西医结合脑病、呼吸睡眠疾病的治疗。
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| 组别 | 例数 | 性别/（例） | 年龄/（岁） | 病程/（年） |
|---|
| 男性 | 女性 |
|---|
| 对照组 | 55 | 32 | 23 | 53.40±6.28 | 3.96±1.17 |
| 观察组 | 55 | 30 | 25 | 52.92±6.10 | 4.05±1.26 |
| χ2/t值 | | 0.148 | 0.407 | 0.388 |
| P值 | | 0.700 | 0.685 | 0.699 |
), ArticleFig(id=1322927073731420718, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927067779703287, language=CN, label=表1, caption=
两组帕金森病合并睡眠障碍患者一般资料比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 性别/（例） | 年龄/（岁） | 病程/（年） |
|---|
| 男性 | 女性 |
|---|
| 对照组 | 55 | 32 | 23 | 53.40±6.28 | 3.96±1.17 |
| 观察组 | 55 | 30 | 25 | 52.92±6.10 | 4.05±1.26 |
| χ2/t值 | | 0.148 | 0.407 | 0.388 |
| P值 | | 0.700 | 0.685 | 0.699 |
), ArticleFig(id=1322927073815306799, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927067779703287, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治愈 | 好转 | 无效 | 总有效 |
|---|
| 观察组 | 55 | 29（52.73） | 24（43.64） | 2（3.64） | 53（96.36） |
| 对照组 | 55 | 24（43.64） | 22（40.00） | 9（16.36） | 46（83.64） |
| χ2值 | | | | | 4.950 |
| P值 | | | | | 0.026 |
), ArticleFig(id=1322927073957913136, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927067779703287, language=CN, label=表2, caption=
两组帕金森病合并睡眠障碍患者临床疗效比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治愈 | 好转 | 无效 | 总有效 |
|---|
| 观察组 | 55 | 29（52.73） | 24（43.64） | 2（3.64） | 53（96.36） |
| 对照组 | 55 | 24（43.64） | 22（40.00） | 9（16.36） | 46（83.64） |
| χ2值 | | | | | 4.950 |
| P值 | | | | | 0.026 |
), ArticleFig(id=1322927074045993521, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927067779703287, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗前 | 治疗2周后 | t值 | P值 |
|---|
| 观察组 | 55 | 13.85±3.10 | 7.92±1.83 | 12.217 | <0.001 |
| 对照组 | 55 | 14.01±2.96 | 9.14±2.11 | 9.936 | <0.001 |
| t值 | | 0.277 | 3.239 | - | - |
| P值 | | 0.782 | 0.002 | - | - |
), ArticleFig(id=1322927074129879602, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927067779703287, language=CN, label=表3, caption=
两组帕金森病合并睡眠障碍患者ESS评分比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗前 | 治疗2周后 | t值 | P值 |
|---|
| 观察组 | 55 | 13.85±3.10 | 7.92±1.83 | 12.217 | <0.001 |
| 对照组 | 55 | 14.01±2.96 | 9.14±2.11 | 9.936 | <0.001 |
| t值 | | 0.277 | 3.239 | - | - |
| P值 | | 0.782 | 0.002 | - | - |
), ArticleFig(id=1322927074230542899, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927067779703287, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 测定时间 | 睡眠效率/（%） | 睡眠潜伏期/（min） | 觉醒次数/（次） | AHI | 最低血氧饱和度/（%） |
|---|
| 观察组 | 55 | 治疗前 | 63.70±5.44 | 42.51±9.46 | 4.06±0.95 | 14.85±3.21 | 82.40±4.74 |
| | 治疗2周后 | 78.89±6.20 | 23.10±4.08 | 1.97±0.56 | 9.08±1.03 | 89.15±5.80 |
| | t1值 | 13.657 | 13.972 | 14.055 | 12.693 | 6.683 |
| | P1值 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
| 对照组 | 55 | 治疗前 | 64.02±5.70 | 42.33±9.21 | 4.11±0.84 | 14.98±3.46 | 82.18±4.92 |
| 55 | 治疗2周后 | 73.39±6.14 | 27.82±5.26 | 2.75±0.67 | 11.71±1.34 | 86.30±5.52 |
| | t2值 | 8.294 | 10.146 | 9.387 | 6.356 | 4.132 |
| | P2值 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
| 两组治疗前比较 | t3值 | 0.301 | 0.101 | 0.292 | 0.204 | 0.239 |
| P3值 | 0.764 | 0.920 | 0.771 | 0.839 | 0.812 |
| 两组治疗2周后比较 | t4值 | 4.675 | 5.258 | 6.625 | 11.540 | 2.640 |
| P4值 | <0.001 | <0.001 | <0.001 | <0.001 | 0.010 |
), ArticleFig(id=1322927074322817588, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927067779703287, language=CN, label=表4, caption=
两组帕金森病合并睡眠障碍患者睡眠结构各指标比较（
±s）
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| 组别 | 例数 | 测定时间 | 睡眠效率/（%） | 睡眠潜伏期/（min） | 觉醒次数/（次） | AHI | 最低血氧饱和度/（%） |
|---|
| 观察组 | 55 | 治疗前 | 63.70±5.44 | 42.51±9.46 | 4.06±0.95 | 14.85±3.21 | 82.40±4.74 |
| | 治疗2周后 | 78.89±6.20 | 23.10±4.08 | 1.97±0.56 | 9.08±1.03 | 89.15±5.80 |
| | t1值 | 13.657 | 13.972 | 14.055 | 12.693 | 6.683 |
| | P1值 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
| 对照组 | 55 | 治疗前 | 64.02±5.70 | 42.33±9.21 | 4.11±0.84 | 14.98±3.46 | 82.18±4.92 |
| 55 | 治疗2周后 | 73.39±6.14 | 27.82±5.26 | 2.75±0.67 | 11.71±1.34 | 86.30±5.52 |
| | t2值 | 8.294 | 10.146 | 9.387 | 6.356 | 4.132 |
| | P2值 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
| 两组治疗前比较 | t3值 | 0.301 | 0.101 | 0.292 | 0.204 | 0.239 |
| P3值 | 0.764 | 0.920 | 0.771 | 0.839 | 0.812 |
| 两组治疗2周后比较 | t4值 | 4.675 | 5.258 | 6.625 | 11.540 | 2.640 |
| P4值 | <0.001 | <0.001 | <0.001 | <0.001 | 0.010 |
), ArticleFig(id=1322927075992150581, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927067779703287, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 测定时间 | Hcy/（mg/L） | IL-1β/（pg/mL） |
|---|
| 观察组 | 55 | 治疗前 | 1.37±0.13 | 14.96±3.12 |
| | 治疗后 | 1.01±0.06 | 8.90±1.85 |
| | t1值 | 18.647 | 12.390 |
| | P1值 | <0.001 | <0.001 |
| 对照组 | 55 | 治疗前 | 1.39±0.10 | 15.04±3.04 |
| | 治疗后 | 1.20±0.06 | 10.13±1.91 |
| | t2值 | 12.083 | 10.142 |
| | P2值 | <0.001 | <0.001 |
| 两组治疗前比较 | | t3值 | 0.904 | 0.136 |
| | P3值 | 0.368 | 0.892 |
| 两组治疗后比较 | | t4值 | 16.606 | 3.431 |
| | P4值 | <0.001 | 0.001 |
), ArticleFig(id=1322927076071842358, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927067779703287, language=CN, label=表5, caption=
两组帕金森病合并睡眠障碍患者血清Hcy及IL-1β水平比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 测定时间 | Hcy/（mg/L） | IL-1β/（pg/mL） |
|---|
| 观察组 | 55 | 治疗前 | 1.37±0.13 | 14.96±3.12 |
| | 治疗后 | 1.01±0.06 | 8.90±1.85 |
| | t1值 | 18.647 | 12.390 |
| | P1值 | <0.001 | <0.001 |
| 对照组 | 55 | 治疗前 | 1.39±0.10 | 15.04±3.04 |
| | 治疗后 | 1.20±0.06 | 10.13±1.91 |
| | t2值 | 12.083 | 10.142 |
| | P2值 | <0.001 | <0.001 |
| 两组治疗前比较 | | t3值 | 0.904 | 0.136 |
| | P3值 | 0.368 | 0.892 |
| 两组治疗后比较 | | t4值 | 16.606 | 3.431 |
| | P4值 | <0.001 | 0.001 |
), ArticleFig(id=1322927076164117047, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927067779703287, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 厌食 | 恶心 | 合计 |
|---|
| 观察组 | 55 | 5（9.09） | 3（5.45） | 8（14.55） |
| 对照组 | 55 | 2（3.64） | 4（7.27） | 6（10.91） |
| χ2值 | | | | 0.327 |
| P值 | | | | 0.567 |
), ArticleFig(id=1322927076268974648, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927067779703287, language=CN, label=表6, caption=
两组帕金森病合并睡眠障碍患者不良反应情况比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 厌食 | 恶心 | 合计 |
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| 观察组 | 55 | 5（9.09） | 3（5.45） | 8（14.55） |
| 对照组 | 55 | 2（3.64） | 4（7.27） | 6（10.91） |
| χ2值 | | | | 0.327 |
| P值 | | | | 0.567 |
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