Article(id=1322926768830689869, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926492627378659, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.09.037, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339920480, onlineDateStr=2026-10-30, pubDate=1757433600000, pubDateStr=2025-09-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339920480, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339920480, creator=13701087609, updateTime=1793339920480, updator=13701087609, issue=Issue{id=1322926492627378659, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='9', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1757433600000', pubDateStr='2025-09-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339854628, creator='13701087609', updateTime=1793340762858, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322930302095590169, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926492627378659, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322930302095590170, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926492627378659, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=202, endPage=205, ext={EN=ArticleExt(id=1322926769166234190, articleId=1322926768830689869, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Clinical Effect of Fupi Yishen Recipe（扶脾益肾方）Combined with Manual Root Surface Leveling in Treatment of Severe Chronic Periodontitis（Spleen-Kidney Yang Deficiency Type）and Its Influence on Inflammatory Factors in Patients, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical effect of Fupi Yishen Recipe（扶脾益肾方）combined with manual root surface leveling in the treatmentof severe chronic periodontitis（spleen-kidney Yang deficiency type）and its effecton inflammatory factors.
Methods A total of 102 patients with severe chronic periodontitis（spleen-kidney-yang deficiency type）admitted from January 2020 to January 2024 were included in the group study. The patients were divided into the simple operation group and the combined Chinese medicine group by random number tablemethod，with 51 cases in each group. All patients in the simple operation group received manual root planarization treatment. Those in the combined Chinese medicine group were treated with manual root surface leveling and Fupi Yishen Recipe. During the treatmentand study，1 patient in the simple operation group fell off，and 2 patients in the combined Chinese medicine group fell off. The clinical efficacy，integral changes of TCM symptoms（main symptoms，secondary symptoms and tongue and pulse）before and after treatment，the changes of periodontal index and concentration of inflammatory factors in gingival crevicular fluid，the changes of masticatory function（bite force and masticatory efficiency）and the adverse reactions of treatmentof two groupswere observed.
Results The total effective rate of the combined Chinese medicine group was higher than thatof the operation group（P<0.05）. Before treatment，the scores of TCM symptoms（main symptoms，secondary symptoms and tongue and pulse），periodontal indices such as gingival bleeding index（BI），plaque index（PLI）and loss ofattachment（AL），depth of periodontal probe（PD），concentration of inflammatory factors such as tumor necrosis factor-α（TNF-α）and interleukin-1β（IL-1β）in gingival crevicular fluid，and chewing function（biting force）of patients in both groups had no significance（all P>0.05）. After treatment，the above indexes were all improved and those in the combined Chinese medicine group were better than those in the simple operation group（all P<0.05）. No serious adverse reactions were observed in the combined Chinese medicine group and the simple operation group（P>0.05）.
Conclusion Fupi Yishen Recipe combined with manual root surface leveling has significant clinical effect in the treatment of severe chronic periodontitis（spleen-kidney Yang deficiency type），which can effectively reduce the concentration of inflammatory factors in gingival crevicular fluid，improve the clinical symptoms，periodontal index and masticatory function of patients and promote the recovery of patients. The treatment is relatively safe and reliable.
, authors=Wenhui JIANG, Zheng CAO, Yin LI, authorsList=Wenhui JIANG, Zheng CAO, Yin LI, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322926773306012247, articleId=1322926768830689869, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=扶脾益肾方结合手工根面平整术治疗重度慢性牙周炎（脾肾阳虚型）临床效果及对炎性因子影响观察, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 观察扶脾益肾方结合手工根面平整术治疗重度慢性牙周炎（脾肾阳虚型）临床效果及对患者炎性因子影响。
方法 共计纳入102例重度慢性牙周炎（脾肾阳虚型）患者（2020年1月—2024年1月收治）进行分组研究，以随机数字表法将患者分为单纯手术组与结合中药组，各组51例，单纯手术组患者均行手工根面平整术治疗，结合中药组患者采取手工根面平整术治疗同时结合扶脾益肾方治疗，治疗及研究过程中单纯手术组患者脱落1例，结合中药组患者脱落2例，各组患者数据观察：临床疗效、治疗前后中医证候（主症、次症与舌脉）积分变化、牙周指数变化及龈沟液内炎症因子浓度变化、咀嚼功能（咬合力和咀嚼效率）变化、治疗不良反应。
结果 结合中药组患者治疗总有效率比单纯手术组更高，P<0.05；各组患者治疗前中医症候（主症、次症与舌脉）积分、牙龈出血指数（Gingival bleeding index，BI）、菌斑指数（plaque index，PLI）及附着丧失（Attachment loss，AL）、牙周探诊深度（probing depth，PD）等牙周指数、龈沟液内肿瘤坏死因子-α（Tumor Necrosis Factor-α，TNF-α）与白细胞介素-1β（Interleukin-1β，IL-1β）等炎症因子浓度、咀嚼功能（咬合力和咀嚼效率）等指标比较，均P>0.05，各组患者治疗后以上指标均显著改善，而结合中药组患者治疗后以上指标改善程度均优于单纯手术组患者，均P<0.05；结合中药组与单纯手术组均未见严重不良反应发生，P>0.05。
结论 扶脾益肾方结合手工根面平整术治疗重度慢性牙周炎（脾肾阳虚型）临床效果显著，可较好降低患者龈沟液内炎症因子浓度，改善患者临床症状及牙周指数、咀嚼功能，促进患者恢复，治疗较为安全可靠。
, authors=蒋文卉, 曹峥, 李寅, authorsList=蒋文卉, 曹峥, 李寅, authorCompany=null, correspAuthors=null, authorNote=
蒋文卉（1983-），女，浙江湖州人，主治医师，硕士，研究方向：牙周疾病。
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中国美容医学，
2023，
32（6）：104-108., articleTitle=基质金属蛋白酶3基因多态性与新疆维吾尔族成人慢性牙周炎的相关研究, refAbstract=null), Reference(id=1322926785373024906, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=39, issue=9, pageStart=545, pageEnd=550, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=张雪舟, 向梅, 温珺珺, journalName=临床口腔医学杂志, refType=null, unstructuredReference=张雪舟，向梅，温珺珺. 慢性牙周炎患者牙龈组织iNOS、Arg1以及STAT6 mRNA表达及相关性分析［J］.
临床口腔医学杂志，
2023，
39（9）：545-550., articleTitle=慢性牙周炎患者牙龈组织iNOS、Arg1以及STAT6 mRNA表达及相关性分析, refAbstract=null), Reference(id=1322926785486271115, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=31, issue=1, pageStart=30, pageEnd=34, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=史文秀, 刘惠萍, 赵雪莹, journalName=北京口腔医学, refType=null, unstructuredReference=史文秀，刘惠萍，赵雪莹，
等. 慢性牙周炎病变位点EB病毒感染与IL-1β和SFRP1含量之间的相关性［J］.
北京口腔医学，
2023，
31（1）：30-34., articleTitle=慢性牙周炎病变位点EB病毒感染与IL-1β和SFRP1含量之间的相关性, refAbstract=null), Reference(id=1322926785544991372, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=45, issue=5, pageStart=475, pageEnd=478, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=徐频频, 闫俊杰, 陈勇, journalName=浙江医学, refType=null, unstructuredReference=徐频频，闫俊杰，陈勇，
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浙江医学，
2023，
45（5）：475-478., articleTitle=慢性牙周炎患者龈沟液MIF、β-catenin表达与疾病严重程度的关系, refAbstract=null), Reference(id=1322926785612100237, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=32, issue=7, pageStart=150, pageEnd=154, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=赵燕, 宦俊霞, journalName=中国美容医学, refType=null, unstructuredReference=赵燕，宦俊霞. 慢性牙周炎患者病情程度对口腔健康相关生活质量的影响［J］.
中国美容医学，
2023，
32（7）：150-154., articleTitle=慢性牙周炎患者病情程度对口腔健康相关生活质量的影响, refAbstract=null), Reference(id=1322926785679209102, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=43, issue=18, pageStart=4450, pageEnd=4452, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=刘振丽, 王钟华, 杨永超, journalName=中国老年学杂志, refType=null, unstructuredReference=刘振丽，王钟华，杨永超，
等. 基础治疗联合激光治疗对老年慢性牙周炎患者咀嚼功能及牙龈微循环指标的影响［J］.
中国老年学杂志，
2023，
43（18）：4450-4452., articleTitle=基础治疗联合激光治疗对老年慢性牙周炎患者咀嚼功能及牙龈微循环指标的影响, refAbstract=null), Reference(id=1322926785729540751, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=21, issue=11, pageStart=275, pageEnd=281, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=赵储欣, 黄鹏, journalName=生命科学仪器, refType=null, unstructuredReference=赵储欣，黄鹏. 老年慢性牙周炎患者半导体激光治疗的应用效果评价［J］.
生命科学仪器，
2023，
21（11）：275-281., articleTitle=老年慢性牙周炎患者半导体激光治疗的应用效果评价, refAbstract=null), Reference(id=1322926785779872400, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=21, issue=11, pageStart=371, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=龙溢鑫, journalName=生命科学仪器, refType=null, unstructuredReference=龙溢鑫. 黄连上清胶囊联合牙周基础治疗对慢性牙周炎患者临床疗效及龈沟液炎症因子水平的影响［J］.
生命科学仪器，
2023，
21（11）：371., articleTitle=黄连上清胶囊联合牙周基础治疗对慢性牙周炎患者临床疗效及龈沟液炎症因子水平的影响, refAbstract=null), Reference(id=1322926785863758481, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=32, issue=2, pageStart=90, pageEnd=93, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=门贝, 李永军, 张曼, journalName=中国药业, refType=null, unstructuredReference=门贝，李永军，张曼. 克林霉素联合甲硝唑治疗慢性牙周炎临床评价［J］.
中国药业，
2023，
32（2）：90-93., articleTitle=克林霉素联合甲硝唑治疗慢性牙周炎临床评价, refAbstract=null), Reference(id=1322926785956033170, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=38, issue=8, pageStart=1094, pageEnd=1097, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=杜奉荣, 顾晓静, 张瑞华, journalName=川北医学院学报, refType=null, unstructuredReference=杜奉荣，顾晓静，张瑞华，
等. 高压氧联合替硝唑片治疗慢性牙周炎临床效果及其对牙周微生态的影响［J］.
川北医学院学报，
2023，
38（8）：1094-1097., articleTitle=高压氧联合替硝唑片治疗慢性牙周炎临床效果及其对牙周微生态的影响, refAbstract=null), Reference(id=1322926786023142035, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=32, issue=5, pageStart=146, pageEnd=150, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=司玲, 崔蕾, 武光杰, journalName=中国美容医学, refType=null, unstructuredReference=司玲，崔蕾，武光杰，
等. 盐酸米诺环素联合布洛芬治疗慢性牙周炎的疗效研究［J］.
中国美容医学，
2023，
32（5）：146-150., articleTitle=盐酸米诺环素联合布洛芬治疗慢性牙周炎的疗效研究, refAbstract=null), Reference(id=1322926786094445204, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=20, issue=30, pageStart=125, pageEnd=129, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=俞梅, 刘思佳, 喻锦娴, journalName=中国医药导报, refType=null, unstructuredReference=俞梅，刘思佳，喻锦娴. 扶脾益肾汤辅助治疗脾肾阳虚型中重度慢性牙周炎的临床效果［J］.
中国医药导报，
2023，
20（30）：125-129., articleTitle=扶脾益肾汤辅助治疗脾肾阳虚型中重度慢性牙周炎的临床效果, refAbstract=null), Reference(id=1322926786161554069, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=31, issue=2, pageStart=105, pageEnd=108, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=赵永超, 吴瑞卿, 李雅娟, journalName=北京口腔医学, refType=null, unstructuredReference=赵永超，吴瑞卿，李雅娟. Er：YAG激光辅助龈下刮治和根面平整术治疗慢性牙周炎伴2型糖尿病的临床疗效［J］.
北京口腔医学，
2023，
31（2）：105-108., articleTitle=Er：YAG激光辅助龈下刮治和根面平整术治疗慢性牙周炎伴2型糖尿病的临床疗效, refAbstract=null), Reference(id=1322926786228662934, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=39, issue=4, pageStart=224, pageEnd=227, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=贺颖, 贾迎春, 佘文哲, journalName=临床口腔医学杂志, refType=null, unstructuredReference=贺颖，贾迎春，佘文哲. SRP治疗后予以咬合调整方案对慢性牙周炎患者临床疗效分析［J］.
临床口腔医学杂志，
2023，
39（4）：224-227., articleTitle=SRP治疗后予以咬合调整方案对慢性牙周炎患者临床疗效分析, refAbstract=null), Reference(id=1322926786295771799, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=32, issue=1, pageStart=131, pageEnd=134, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=曹海萌, 盛明珠, 汤巧巧, journalName=中国美容医学, refType=null, unstructuredReference=曹海萌，盛明珠，汤巧巧. 牙周组织再生术联合口腔正畸治疗对慢性牙周炎患者口腔功能及TNF-α、CRP水平的影响［J］.
中国美容医学，
2023，
32（1）：131-134., articleTitle=牙周组织再生术联合口腔正畸治疗对慢性牙周炎患者口腔功能及TNF-α、CRP水平的影响, refAbstract=null), Reference(id=1322926786358686360, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=32, issue=6, pageStart=814, pageEnd=818, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=华超, 郅晓雷, 于晓艳, journalName=现代中西医结合杂志, refType=null, unstructuredReference=华超，郅晓雷，于晓艳，
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现代中西医结合杂志，
2023，
32（6）：814-818., articleTitle=清齿含漱方结合低能量激光照射疗法治疗重度慢性牙周炎疗效观察, refAbstract=null), Reference(id=1322926786509681305, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=23, issue=3, pageStart=317, pageEnd=320, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=高尚, 熊伯刚, 冯培明, journalName=中国医院用药评价与分析, refType=null, unstructuredReference=高尚，熊伯刚，冯培明，
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中国医院用药评价与分析，
2023，
23（3）：317-320., articleTitle=人工牛黄甲硝唑胶囊联合多西环素治疗慢性牙周炎的疗效及对龈沟液和血清中RANKL、MMP-8、NE、sICAM-1水平的影响, refAbstract=null), Reference(id=1322926786576790170, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=23, issue=10, pageStart=1955, pageEnd=1959, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=杨学广, 林瑜, 郭方亮, journalName=现代生物医学进展, refType=null, unstructuredReference=杨学广，林瑜，郭方亮，
等. 牙周基础治疗对慢性牙周炎伴冠心病患者血清炎症因子、龈下菌群和龈沟液中自噬因子的影响［J］.
现代生物医学进展，
2023，
23（10）：1955-1959., articleTitle=牙周基础治疗对慢性牙周炎伴冠心病患者血清炎症因子、龈下菌群和龈沟液中自噬因子的影响, refAbstract=null), Reference(id=1322926786639704731, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=28, issue=2, pageStart=2, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=雷剑辉, journalName=中国临床药理学与治疗学, refType=null, unstructuredReference=雷剑辉. 慢性牙周炎患者应用牙种植修复治疗的效果观察［J］.
中国临床药理学与治疗学，
2023，
28（2）：2., articleTitle=慢性牙周炎患者应用牙种植修复治疗的效果观察, refAbstract=null), Reference(id=1322926786702619292, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=34, issue=5, pageStart=691, pageEnd=696, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=何翔, 周洪玲, 魏静, journalName=中药新药与临床药理, refType=null, unstructuredReference=何翔，周洪玲，魏静，
等. 口腔洁含漱液联合牙周基础治疗对慢性牙周炎伴2型糖尿病患者牙周状态及龈沟液炎症因子水平的影响［J］.
中药新药与临床药理，
2023，
34（5）：691-696., articleTitle=口腔洁含漱液联合牙周基础治疗对慢性牙周炎伴2型糖尿病患者牙周状态及龈沟液炎症因子水平的影响, refAbstract=null), Reference(id=1322926786769728157, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=31, issue=5, pageStart=486, pageEnd=490, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=胡龑龑, 李鹏, 王勋, journalName=中华高血压杂志, refType=null, unstructuredReference=胡龑龑，李鹏，王勋，
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中华高血压杂志，
2023，
31（5）：486-490., articleTitle=牙周基础治疗对慢性牙周炎合并阵发性房颤的影响, refAbstract=null), Reference(id=1322926786845225630, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=38, issue=4, pageStart=919, pageEnd=923, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=张帆, 马丽芳, journalName=现代药物与临床, refType=null, unstructuredReference=张帆，马丽芳. 齿痛消炎灵颗粒联合浓替硝唑含漱液治疗慢性牙周炎的临床研究［J］.
现代药物与临床，
2023，
38（4）：919-923., articleTitle=齿痛消炎灵颗粒联合浓替硝唑含漱液治疗慢性牙周炎的临床研究, refAbstract=null), Reference(id=1322926788522947231, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=42, issue=3, pageStart=42, pageEnd=45, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=项志强, 黄菲菲, 郑海燕, journalName=中华中医药学刊, refType=null, unstructuredReference=项志强，黄菲菲，郑海燕，
等. 补肾固齿丸对中老年慢性牙周炎临床疗效及血清免疫球蛋白、炎症因子水平影响研究［J］.
中华中医药学刊，
2023，
42（3）：42-45., articleTitle=补肾固齿丸对中老年慢性牙周炎临床疗效及血清免疫球蛋白、炎症因子水平影响研究, refAbstract=null), Reference(id=1322926788585861792, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2021, volume=39, issue=10, pageStart=199, pageEnd=203, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=林昌, 许海燕, journalName=中华中医药学刊, refType=null, unstructuredReference=林昌，许海燕. 加味清胃汤联合盐酸米诺环素治疗慢性牙周炎的疗效及对龈沟液IL-1β、IL-6和PGE2水平影响［J］.
中华中医药学刊，
2021，
39（10）：199-203., articleTitle=加味清胃汤联合盐酸米诺环素治疗慢性牙周炎的疗效及对龈沟液IL-1β、IL-6和PGE2水平影响, refAbstract=null), Reference(id=1322926788665553569, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2021, volume=30, issue=10, pageStart=178, pageEnd=181, url=null, language=null, rfNumber=[29], rfOrder=28, authorNames=李瑛琦, 张煜培, 王晨茜, journalName=中国美容医学, refType=null, unstructuredReference=李瑛琦，张煜培，王晨茜，
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中国美容医学，
2021，
30（10）：178-181., articleTitle=慢性牙周炎的中医药治疗研究进展, refAbstract=null), Reference(id=1322926788749439650, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, doi=null, pmid=null, pmcid=null, year=2023, volume=39, issue=12, pageStart=1370, pageEnd=1373, url=null, language=null, rfNumber=[30], rfOrder=29, authorNames=李莉, 郜珍燕, 孙俊毅, journalName=长春中医药大学学报, refType=null, unstructuredReference=李莉，郜珍燕，孙俊毅. 盐酸米诺环素联合替硝唑对慢性牙周炎的影响［J］.
长春中医药大学学报，
2023，
39（12）：1370-1373., articleTitle=盐酸米诺环素联合替硝唑对慢性牙周炎的影响, refAbstract=null)], funds=[Fund(id=1322926784655798916, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, awardId=2024ZL1025, language=CN, fundingSource=浙江省中医药科技计划项目(2024ZL1025), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322926774191010392, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, xref=null, ext=[AuthorCompanyExt(id=1322926774207787609, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, companyId=1322926774191010392, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Stomatology，Huzhou Central Hospital，The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University，Huzhou 313000，Zhejiang，China), AuthorCompanyExt(id=1322926774216176218, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, companyId=1322926774191010392, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖州市中心医院，浙江中医药大学第五临床医学院，浙江 湖州 313000)])], figs=[ArticleFig(id=1322926781338104440, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 单纯手术组 | 50 | 29 | 13 | 8 | 42（84.00） |
| 结合中药组 | 49 | 37 | 10 | 2 | 47（95.92） |
| χ2值 | - | - | - | - | 3.871 2 |
| P值 | - | - | - | - | 0.049 1 |
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两组重度慢性牙周炎患者临床治疗效果比较
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| 组别 | 例数 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 单纯手术组 | 50 | 29 | 13 | 8 | 42（84.00） |
| 结合中药组 | 49 | 37 | 10 | 2 | 47（95.92） |
| χ2值 | - | - | - | - | 3.871 2 |
| P值 | - | - | - | - | 0.049 1 |
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| 组别 | 例数 | 治疗时间 | 主症积分 | 次症积分 | 舌脉积分 |
|---|
| 单纯手术组 | 50 | 治疗前 | 12.24±0.43 | 10.45±1.00 | 4.52±0.39 |
| | 治疗后 | 3.00±0.44* | 1.75±0.28* | 0.95±0.12* |
| 结合中药组 | 49 | 治疗前 | 12.19±0.51 | 10.52±0.95 | 4.49±0.40 |
| | 治疗后 | 1.85±0.21*# | 0.85±0.12*# | 0.45±0.08*# |
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两组重度慢性牙周炎患者治疗前后中医证候（主症、次症与舌脉）积分比较（
±s）
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| 组别 | 例数 | 治疗时间 | 主症积分 | 次症积分 | 舌脉积分 |
|---|
| 单纯手术组 | 50 | 治疗前 | 12.24±0.43 | 10.45±1.00 | 4.52±0.39 |
| | 治疗后 | 3.00±0.44* | 1.75±0.28* | 0.95±0.12* |
| 结合中药组 | 49 | 治疗前 | 12.19±0.51 | 10.52±0.95 | 4.49±0.40 |
| | 治疗后 | 1.85±0.21*# | 0.85±0.12*# | 0.45±0.08*# |
), ArticleFig(id=1322926781698814588, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗时间 | BI/（分） | PLI/（分） | AL/（mm） | PD/（mm） |
|---|
| 单纯手术组 | 50 | 治疗前 | 4.49±0.41 | 1.84±0.35 | 5.84±0.34 | 6.79±0.41 |
| | 治疗后 | 3.03±0.28* | 1.18±0.26* | 3.46±0.33* | 3.30±0.40* |
| 结合中药组 | 49 | 治疗前 | 4.52±0.39 | 1.79±0.39 | 5.79±0.29 | 6.73±0.37 |
| | 治疗后 | 2.73±0.36*# | 0.71±0.11*# | 2.51±0.30*# | 2.64±0.22*# |
), ArticleFig(id=1322926781761729149, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, language=CN, label=表3, caption=
两组重度慢性牙周炎患者治疗前后牙周指数（BI及PLI、AL、PD）比较（
±s）
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| 组别 | 例数 | 治疗时间 | BI/（分） | PLI/（分） | AL/（mm） | PD/（mm） |
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| 单纯手术组 | 50 | 治疗前 | 4.49±0.41 | 1.84±0.35 | 5.84±0.34 | 6.79±0.41 |
| | 治疗后 | 3.03±0.28* | 1.18±0.26* | 3.46±0.33* | 3.30±0.40* |
| 结合中药组 | 49 | 治疗前 | 4.52±0.39 | 1.79±0.39 | 5.79±0.29 | 6.73±0.37 |
| | 治疗后 | 2.73±0.36*# | 0.71±0.11*# | 2.51±0.30*# | 2.64±0.22*# |
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| 组别 | 例数 | 治疗时间 | TNF-α | IL-1β |
|---|
| 单纯手术组 | 50 | 治疗前 | 433.26±15.23 | 6.55±0.67 |
| | 治疗后 | 312.65±10.64* | 4.89±0.36* |
| 结合中药组 | 49 | 治疗前 | 431.65±16.34 | 6.49±0.70 |
| | 治疗后 | 247.62±9.72*# | 2.46±0.32*# |
), ArticleFig(id=1322926782126633599, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, language=CN, label=表4, caption=
两组重度慢性牙周炎患者治疗前后龈沟液内炎症因子浓度（TNF-α及IL-1β）比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗时间 | TNF-α | IL-1β |
|---|
| 单纯手术组 | 50 | 治疗前 | 433.26±15.23 | 6.55±0.67 |
| | 治疗后 | 312.65±10.64* | 4.89±0.36* |
| 结合中药组 | 49 | 治疗前 | 431.65±16.34 | 6.49±0.70 |
| | 治疗后 | 247.62±9.72*# | 2.46±0.32*# |
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| 组别 | 例数 | 治疗时间 | 咬合力（lb） | 咀嚼效率/（%） |
|---|
| 单纯手术组 | 50 | 治疗前 | 80.53±5.23 | 56.23±6.62 |
| | 治疗后 | 99.65±4.31* | 82.35±5.52* |
| 结合中药组 | 49 | 治疗前 | 80.48±5.31 | 56.18±6.59 |
| | 治疗后 | 134.26±3.99*# | 90.52±4.92*# |
), ArticleFig(id=1322926782273434241, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, language=CN, label=表5, caption=
两组重度慢性牙周炎患者治疗前后咀嚼功能（咬合力和咀嚼效率）指标比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗时间 | 咬合力（lb） | 咀嚼效率/（%） |
|---|
| 单纯手术组 | 50 | 治疗前 | 80.53±5.23 | 56.23±6.62 |
| | 治疗后 | 99.65±4.31* | 82.35±5.52* |
| 结合中药组 | 49 | 治疗前 | 80.48±5.31 | 56.18±6.59 |
| | 治疗后 | 134.26±3.99*# | 90.52±4.92*# |
), ArticleFig(id=1322926782550258306, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926768830689869, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 口干 | 头晕 | 总不良反应 |
|---|
| 单纯手术组 | 50 | 0 | 0 | 0（0.00） |
| 结合中药组 | 49 | 1 | 1 | 2（4.08） |
| χ2值 | - | - | - | 2.082 9 |
| P值 | - | - | - | 0.149 0 |
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两组重度慢性牙周炎患者临床不良反应率比较
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| 组别 | 例数 | 口干 | 头晕 | 总不良反应 |
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| 结合中药组 | 49 | 1 | 1 | 2（4.08） |
| χ2值 | - | - | - | 2.082 9 |
| P值 | - | - | - | 0.149 0 |
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