Article(id=1322927719553565478, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.08.031, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793340147150, onlineDateStr=2026-10-30, pubDate=1754755200000, pubDateStr=2025-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793340147150, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793340147150, creator=13701087609, updateTime=1793340147150, updator=13701087609, issue=Issue{id=1322926217711726961, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1754755200000', pubDateStr='2025-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339789083, creator='13701087609', updateTime=1793340517761, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929274071679978, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929274071679979, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=159, endPage=166, ext={EN=ArticleExt(id=1322927720073659175, articleId=1322927719553565478, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress and Prediction Analysis of Quality Markers(Q-Marker)of Baihuasheshecao(Hedyotidis Diffusae Herba), columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Baihuasheshecao(Hedyotidis Diffusae Herba)is a traditional Chinese medicine in China with a history of thousands of years,and its chemical composition is diverse,including flavonoids and their glycosides,terpenoids,anthraquinones,steroids,organic acids,phenylpropanin and coumarin.Modern studies have shown that Baihuasheshecao(Hedyotidis Diffusae Herba)has anti-tumor,anti-inflammatory,antibacterial,antioxidant and immune system modulation pharmacological effects.In this paper,the chemical composition and pharmacological effects of quality Marker(Q-Marker)were summarized,and according to the concept of Q-Marker,it analyzed and predicted the Q-Markers of Baihuasheshecao(Hedyotidis Diffusae Herba)from the aspects of plant genelogy,traditional medicinal properties and efficacy,chemical composition traceability,different origins and harvest periods,compound compatibility and chemical composition measurability,in order to provide a basis for the establishment of a comprehensive and scientific quality control system of Q-Marker.

, authors=Huayu WANG1, 2, Mingming WU1, 2, Lianrui WANG1, 2, Mingsan MIAO1, 2, authorsList=Huayu WANG, Mingming WU, Lianrui WANG, Mingsan MIAO, authorCompany=null, correspAuthors=Mingsan MIAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322927721281618728, articleId=1322927719553565478, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=白花蛇舌草研究进展及质量标志物(Q-Marker)的预测分析, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

白花蛇舌草是我国传统中药,已有上千年历史,其化学成分多样,包含有黄酮类及其苷类、萜类、蒽醌类、甾体类、有机酸类、苯丙素和香豆素类等多种化学成分。现代研究表明,白花蛇舌草具有抗肿瘤、抗炎、抗菌、抗氧化以及免疫系统调节等药理作用。通过对白花蛇舌草的化学成分、药理作用进行总结,并根据中药质量标志物(quality Marker,QMarker)的概念,从植物亲缘学、传统药性和药效、化学成分溯源性、不同产地和采收时期、复方配伍以及化学成分可测性几个方面对白花蛇舌草的质量标志物进行分析预测,以期为建立全面科学的白花蛇舌草的质量控制体系提供依据。

, authors=王华雨1, 2, 武鸣鸣1, 2, 王连睿1, 2, 苗明三1, 2, authorsList=王华雨, 武鸣鸣, 王连睿, 苗明三, authorCompany=null, correspAuthors=苗明三, authorNote=

王华雨(1999-),男,河南新乡人,硕士在读,研究方向:中药药理学。

, correspAuthorsNote=
苗明三(1965-),男,河南新乡人,教授,博士研究生导师,博士,研究方向:中药药理学。E-mail:。
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2.河南中医药大学豫药全产业链研发河南省协同创新中心,河南 郑州 450046, bio={"content":"

王华雨(1999-),男,河南新乡人,硕士在读,研究方向:中药药理学。

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王华雨(1999-),男,河南新乡人,硕士在读,研究方向:中药药理学。

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HPLC法同时测定白花蛇舌草中槲皮素和东莨菪内酯的含量[J]. 中国药师,2019,22(9):1761-1763., articleTitle=HPLC法同时测定白花蛇舌草中槲皮素和东莨菪内酯的含量, refAbstract=null), Reference(id=1322927743008113618, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, doi=null, pmid=null, pmcid=null, year=2022, volume=42, issue=16, pageStart=1633, pageEnd=1641, url=null, language=null, rfNumber=[105], rfOrder=104, authorNames=王信, 李莉, 张瑞, journalName=中国医院药学杂志, refType=null, unstructuredReference=王信,李莉,张瑞,等. 基于指纹图谱和网络药理学的白花蛇舌草质量标志物预测分析[J]. 中国医院药学杂志,2022,42(16):1633-1641., articleTitle=基于指纹图谱和网络药理学的白花蛇舌草质量标志物预测分析, refAbstract=null)], funds=[Fund(id=1322927726067319649, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, awardId=GZYKJS-2022-040-1, language=CN, fundingSource=国家中医药管理局联合开放课题(GZYKJS-2022-040-1), fundOrder=null, country=null), Fund(id=1322927726142817122, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, awardId=豫科技〔2023〕175号, language=CN, fundingSource=豫药全产业链研发河南省协同创新中心项目(豫科技〔2023〕175号), fundOrder=null, country=null), Fund(id=1322927727799567204, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, awardId=221100310400, language=CN, fundingSource=河南省重大专项(221100310400), fundOrder=null, country=null), Fund(id=1322927727883453285, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, awardId=231111521200, language=CN, fundingSource=河南省国际合作重点项目(231111521200), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322927721763963690, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, xref=1., ext=[AuthorCompanyExt(id=1322927721772352299, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, companyId=1322927721763963690, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China), AuthorCompanyExt(id=1322927722019816236, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, companyId=1322927721763963690, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.河南中医药大学,河南 郑州 450046)]), AuthorCompany(id=1322927723311661870, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, xref=2., ext=[AuthorCompanyExt(id=1322927723320050479, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, companyId=1322927723311661870, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao,Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China), AuthorCompanyExt(id=1322927723328439088, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, companyId=1322927723311661870, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.河南中医药大学豫药全产业链研发河南省协同创新中心,河南 郑州 450046)])], figs=[ArticleFig(id=1322927725001966419, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
序号化合物分子式参考文献
1槲皮素C15H10O7[5]
2毛地黄内酯C11H16O3[6]
3琥珀酸二甲酯C6H10O4[6]
4芦丁C17H30O16[7]
5山柰酚C15H10O6[5]
65-羟基-6,7,3′,4'-四甲氧基黄酮C19H18O7[8]
73-甲氧基-5,7-二羟基-黄酮醇C16H12O5[9]
8异高山黄芩素C15H10O6[10]
92',4',5',5,7-五羟基黄酮C15H12O8[10]
10穗花杉双黄酮C30H18O10[11]
11槲皮素-3-O-β-D-吡喃葡萄糖苷C21H20O12[12]
12山柰酚-3-O-β-D-吡喃葡萄糖苷C21H20O11[12]
13槲皮素-3-O-(2-O-6-D-吡喃葡萄糖基)-β-D-吡喃葡萄糖苷C27H31O17[12]
14山柰酚-3-O-(2-O-6-D-吡喃葡萄糖基)-β-D-吡喃葡萄糖苷C27H31O16[13]
15山柰酚-3-O-[2-O-(6-O-阿魏酰基)-β-D-吡喃葡萄糖基]-β-D-吡喃半乳糖苷C37H38O19[7]
16槲皮素-3-O-[2-O-(6-O-阿魏酰基)-β-D-吡喃葡萄糖基]-β-D-吡喃半乳糖苷C37H38O20[7]
17槲皮素-3-O-[2-O-(6-O-芥子酰基)-β-D-吡喃葡萄糖基]-β-D-吡喃葡萄糖苷C37H42O21[7]
18槲皮素-3-O-[2-O-(6-O-阿魏酰基)-β-D-吡喃葡萄糖基]-β-D-吡喃葡萄糖苷C37H38O20[14]
19山柰酚-3-O-(2-O-β-D-吡喃葡萄糖基)-β-D-吡喃半乳糖苷C27H31O16[14]
20槲皮素-3-O-(2-O-β-D-吡喃葡萄糖基)-β-D-吡喃半乳糖苷C27H31O16[15]
21槲皮素-3-O-桑布双糖苷C26H28O16[16]
22山柰酚-3-O-(6-O-α-L-鼠李糖基)-β-D-吡喃葡萄糖苷C27H31O16[12]
23山柰酚-3-O-[(6-O-E-咖啡酰基)-β-D-吡喃葡萄糖基]-β-D-吡喃半乳糖苷C37H38O19[17]
), ArticleFig(id=1322927725081658196, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, language=CN, label=表1, caption=

白花蛇舌草中的黄酮及苷类化合物

, figureFileSmall=null, figureFileBig=null, tableContent=
序号化合物分子式参考文献
1槲皮素C15H10O7[5]
2毛地黄内酯C11H16O3[6]
3琥珀酸二甲酯C6H10O4[6]
4芦丁C17H30O16[7]
5山柰酚C15H10O6[5]
65-羟基-6,7,3′,4'-四甲氧基黄酮C19H18O7[8]
73-甲氧基-5,7-二羟基-黄酮醇C16H12O5[9]
8异高山黄芩素C15H10O6[10]
92',4',5',5,7-五羟基黄酮C15H12O8[10]
10穗花杉双黄酮C30H18O10[11]
11槲皮素-3-O-β-D-吡喃葡萄糖苷C21H20O12[12]
12山柰酚-3-O-β-D-吡喃葡萄糖苷C21H20O11[12]
13槲皮素-3-O-(2-O-6-D-吡喃葡萄糖基)-β-D-吡喃葡萄糖苷C27H31O17[12]
14山柰酚-3-O-(2-O-6-D-吡喃葡萄糖基)-β-D-吡喃葡萄糖苷C27H31O16[13]
15山柰酚-3-O-[2-O-(6-O-阿魏酰基)-β-D-吡喃葡萄糖基]-β-D-吡喃半乳糖苷C37H38O19[7]
16槲皮素-3-O-[2-O-(6-O-阿魏酰基)-β-D-吡喃葡萄糖基]-β-D-吡喃半乳糖苷C37H38O20[7]
17槲皮素-3-O-[2-O-(6-O-芥子酰基)-β-D-吡喃葡萄糖基]-β-D-吡喃葡萄糖苷C37H42O21[7]
18槲皮素-3-O-[2-O-(6-O-阿魏酰基)-β-D-吡喃葡萄糖基]-β-D-吡喃葡萄糖苷C37H38O20[14]
19山柰酚-3-O-(2-O-β-D-吡喃葡萄糖基)-β-D-吡喃半乳糖苷C27H31O16[14]
20槲皮素-3-O-(2-O-β-D-吡喃葡萄糖基)-β-D-吡喃半乳糖苷C27H31O16[15]
21槲皮素-3-O-桑布双糖苷C26H28O16[16]
22山柰酚-3-O-(6-O-α-L-鼠李糖基)-β-D-吡喃葡萄糖苷C27H31O16[12]
23山柰酚-3-O-[(6-O-E-咖啡酰基)-β-D-吡喃葡萄糖基]-β-D-吡喃半乳糖苷C37H38O19[17]
), ArticleFig(id=1322927725152961365, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
序号化合物分子式参考文献
24齐墩果酸C30H48O3[18]
25白桦脂酸C30H48O3[18]
26熊果酸C30H48O3[18]
276α-O-反式-对香豆酰京尼平苷C32H40O17[19]
2810-去氢京尼平苷酸C15H18O10[19]
29山柑子酮C30H48O[20]
30异山柑子酮C30H50O[20]
), ArticleFig(id=1322927725215875926, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, language=CN, label=表2, caption=

白花蛇舌草中的三萜类化合物

, figureFileSmall=null, figureFileBig=null, tableContent=
序号化合物分子式参考文献
24齐墩果酸C30H48O3[18]
25白桦脂酸C30H48O3[18]
26熊果酸C30H48O3[18]
276α-O-反式-对香豆酰京尼平苷C32H40O17[19]
2810-去氢京尼平苷酸C15H18O10[19]
29山柑子酮C30H48O[20]
30异山柑子酮C30H50O[20]
), ArticleFig(id=1322927725287179095, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
序号化合物分子式参考文献
31山莨菪碱C16H22O12[21]
32山莨菪碱甲酯C17H24O12[22]
33(Z)-6-O-对甲氧基桂皮酰鸡屎藤次苷甲酯C27H32O13[23]
34(E)-6-O-对甲氧基桂皮酰鸡屎藤次苷甲酯C27H30O13[23]
35(Z)-6-O-阿魏酰鸡屎藤次苷甲酯C27H32O14[14]
36(E)-6-O-阿魏酰鸡屎藤次苷甲酯C27H32O14[14]
37(Z)-6-O-p-甲氧基肉桂酰山莨菪碱甲酯C27H34O14[12]
38(E)-6-O-p-甲氧基肉桂酰山莨菪碱甲酯C27H30O14[22]
39(E)-6-O-香豆酰基-10-甲酰基-鸡屎藤次苷甲酯C27H32O13[24]
40(Z)-6-O-香豆酰鸡屎藤次苷甲酯C26H30O13[14]
41(E)-6-O-香豆酰鸡屎藤次苷甲酯C26H30O13[14]
42京尼平苷C16H22O10[25]
4310-去氢京尼平苷C17H22O10[26]
4410-O-苯甲酰-1-O-(6-O-α-L-阿拉伯吡喃糖基)-β-D-吡喃葡萄糖苷C28H34O15[14]
45车叶草苷C18H22O11[14]
46去乙酰车叶草苷C16H20O10[14]
47车叶草苷酸C18H24O12[14]
48车叶草酸甲酯C20H27O14[14]
49去乙酰车叶草酸C16H22O11[21]
50去乙酰车叶草酸甲酯C17H24O11[14]
516-甲氧基去乙酰车叶草酸甲酯C18H25O12[14]
526-乙氧基去乙酰车叶草酸甲酯C18H25O12[14]
53diffusosid(E)AC18H27O12[27]
54diffusosid(E)BC18H27O12[27]
55壬酸甲酯C17H24O12[14]
56羟异栀子苷C17H24O12[14]
57Galioside 10-acetateC18H25O13[25]
58松柏苷C16H22O8[25]
59鸡屎藤次苷C16H22O11[9]
60鸡屎藤次苷甲酯C17H24O11[25]
61乙酰鸡屎藤次苷甲酯C19H26O12[25]
6210-乙酰基鸡屎藤苷C18H24O12[9]
63水晶兰苷甲酯C17H24O11[25]
), ArticleFig(id=1322927725350093656, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, language=CN, label=表3, caption=

白花蛇舌草中的环烯醚萜类化合物

, figureFileSmall=null, figureFileBig=null, tableContent=
序号化合物分子式参考文献
31山莨菪碱C16H22O12[21]
32山莨菪碱甲酯C17H24O12[22]
33(Z)-6-O-对甲氧基桂皮酰鸡屎藤次苷甲酯C27H32O13[23]
34(E)-6-O-对甲氧基桂皮酰鸡屎藤次苷甲酯C27H30O13[23]
35(Z)-6-O-阿魏酰鸡屎藤次苷甲酯C27H32O14[14]
36(E)-6-O-阿魏酰鸡屎藤次苷甲酯C27H32O14[14]
37(Z)-6-O-p-甲氧基肉桂酰山莨菪碱甲酯C27H34O14[12]
38(E)-6-O-p-甲氧基肉桂酰山莨菪碱甲酯C27H30O14[22]
39(E)-6-O-香豆酰基-10-甲酰基-鸡屎藤次苷甲酯C27H32O13[24]
40(Z)-6-O-香豆酰鸡屎藤次苷甲酯C26H30O13[14]
41(E)-6-O-香豆酰鸡屎藤次苷甲酯C26H30O13[14]
42京尼平苷C16H22O10[25]
4310-去氢京尼平苷C17H22O10[26]
4410-O-苯甲酰-1-O-(6-O-α-L-阿拉伯吡喃糖基)-β-D-吡喃葡萄糖苷C28H34O15[14]
45车叶草苷C18H22O11[14]
46去乙酰车叶草苷C16H20O10[14]
47车叶草苷酸C18H24O12[14]
48车叶草酸甲酯C20H27O14[14]
49去乙酰车叶草酸C16H22O11[21]
50去乙酰车叶草酸甲酯C17H24O11[14]
516-甲氧基去乙酰车叶草酸甲酯C18H25O12[14]
526-乙氧基去乙酰车叶草酸甲酯C18H25O12[14]
53diffusosid(E)AC18H27O12[27]
54diffusosid(E)BC18H27O12[27]
55壬酸甲酯C17H24O12[14]
56羟异栀子苷C17H24O12[14]
57Galioside 10-acetateC18H25O13[25]
58松柏苷C16H22O8[25]
59鸡屎藤次苷C16H22O11[9]
60鸡屎藤次苷甲酯C17H24O11[25]
61乙酰鸡屎藤次苷甲酯C19H26O12[25]
6210-乙酰基鸡屎藤苷C18H24O12[9]
63水晶兰苷甲酯C17H24O11[25]
), ArticleFig(id=1322927725433979737, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
序号化合物分子式参考文献
64大黄素C15H10O5[18]
65大黄酸C15H8O6[18]
66芦荟大黄素C15H10O5[18]
67大黄酚C15H10O4[18]
682-羟基-1-甲氧基-3-甲基蒽醌C16H12O5[28]
697-羟基内酯醌C14H10O3[28]
702-丁基-1-羟基-9,10-蒽醌C18H16O3[28]
712,6-二羟基-1-甲氧基蒽醌C15H10O5[29]
722-羟基-3-甲氧基-7-甲基蒽醌C16H12O4[29]
732-羟基-3-甲基蒽醌C15H10O3[19]
742-羟基-7-甲基-3-甲氧基蒽醌C15H12O4[19]
751-甲醛-4-羟基蒽醌C15H8O4[19]
762-羟基-1-甲氧基蒽醌C14H10O4[11]
772-羟基-6-甲基蒽醌C15H10O3[30]
782-羟基-7-甲基蒽醌C15H10O3[21]
792,7-二羟基-3-甲基蒽醌C15H10O4[21]
802-羟基-1,3-二甲氧基蒽醌C15H12O5[11]
812-羟基-3-甲氧基-6-甲基蒽醌C16H12O4[30]
821,3-二甲氧基-2-羟基蒽醌C16H12O5[30]
831,7-二羟基-6-甲氧基-2-甲基蒽醌C16H12O5[31]
842,6-二羟基-1-甲氧基-3-甲基蒽醌C16H12O5[7]
852,6-二羟基-3-甲基-4-甲氧基蒽醌C16H12O5[10]
), ArticleFig(id=1322927725513671514, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, language=CN, label=表4, caption=

白花蛇舌草中的蒽醌类化合物

, figureFileSmall=null, figureFileBig=null, tableContent=
序号化合物分子式参考文献
64大黄素C15H10O5[18]
65大黄酸C15H8O6[18]
66芦荟大黄素C15H10O5[18]
67大黄酚C15H10O4[18]
682-羟基-1-甲氧基-3-甲基蒽醌C16H12O5[28]
697-羟基内酯醌C14H10O3[28]
702-丁基-1-羟基-9,10-蒽醌C18H16O3[28]
712,6-二羟基-1-甲氧基蒽醌C15H10O5[29]
722-羟基-3-甲氧基-7-甲基蒽醌C16H12O4[29]
732-羟基-3-甲基蒽醌C15H10O3[19]
742-羟基-7-甲基-3-甲氧基蒽醌C15H12O4[19]
751-甲醛-4-羟基蒽醌C15H8O4[19]
762-羟基-1-甲氧基蒽醌C14H10O4[11]
772-羟基-6-甲基蒽醌C15H10O3[30]
782-羟基-7-甲基蒽醌C15H10O3[21]
792,7-二羟基-3-甲基蒽醌C15H10O4[21]
802-羟基-1,3-二甲氧基蒽醌C15H12O5[11]
812-羟基-3-甲氧基-6-甲基蒽醌C16H12O4[30]
821,3-二甲氧基-2-羟基蒽醌C16H12O5[30]
831,7-二羟基-6-甲氧基-2-甲基蒽醌C16H12O5[31]
842,6-二羟基-1-甲氧基-3-甲基蒽醌C16H12O5[7]
852,6-二羟基-3-甲基-4-甲氧基蒽醌C16H12O5[10]
), ArticleFig(id=1322927725576586075, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
序号化合物分子式参考文献
86豆甾醇C29H48O[28]
87β-谷甾醇C29H50O[29]
88β-谷甾醇-3-O-β-D-葡萄糖苷C35H60O6[32]
89白果甾醇C29H48O[29]
90豆甾-5,22-二烯-3-β-7-α-二醇C29H48O2[29]
91豆甾-5,22-二烯-3-β-7-β-二醇C29H48O2[5]
923-羟基豆甾-5,22-二烯-7-酮C29H46O2[33]
936-羟基豆甾-4,22-二烯-3-酮C29H46O2[33]
94菜油甾醇C28H48O[10]
95甲基异茜草素C15H10O4[10]
), ArticleFig(id=1322927725656277852, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, language=CN, label=表5, caption=

白花蛇舌草中的甾体类化合物

, figureFileSmall=null, figureFileBig=null, tableContent=
序号化合物分子式参考文献
86豆甾醇C29H48O[28]
87β-谷甾醇C29H50O[29]
88β-谷甾醇-3-O-β-D-葡萄糖苷C35H60O6[32]
89白果甾醇C29H48O[29]
90豆甾-5,22-二烯-3-β-7-α-二醇C29H48O2[29]
91豆甾-5,22-二烯-3-β-7-β-二醇C29H48O2[5]
923-羟基豆甾-5,22-二烯-7-酮C29H46O2[33]
936-羟基豆甾-4,22-二烯-3-酮C29H46O2[33]
94菜油甾醇C28H48O[10]
95甲基异茜草素C15H10O4[10]
), ArticleFig(id=1322927725727581021, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
序号化合物分子式参考文献
96对甲氧基反式肉桂酸C10H10O3[31]
97香豆酸C6H4O4[11]
983,4-二羟基苯甲酸C7H6O4[8]
99阿魏酸C10H10O4[31]
100咖啡酸C9H8O4[8]
101丁二酸C4H6O4[31]
), ArticleFig(id=1322927725798884190, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, language=CN, label=表6, caption=

白花蛇舌草中的含酸化合物

, figureFileSmall=null, figureFileBig=null, tableContent=
序号化合物分子式参考文献
96对甲氧基反式肉桂酸C10H10O3[31]
97香豆酸C6H4O4[11]
983,4-二羟基苯甲酸C7H6O4[8]
99阿魏酸C10H10O4[31]
100咖啡酸C9H8O4[8]
101丁二酸C4H6O4[31]
), ArticleFig(id=1322927725878575967, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
序号化合物分子式参考文献
102秦皮甲素C15H16O9[10]
103东莨菪内酯C10H8O4[5]
104反式对羟基桂皮酸十八酯C27H44O3[31]
1057-羟基-6-甲氧基香豆素C10H8O4[31]
1067R,7'R,8S,8'S-(+)-新橄榄树脂素C20H24O7[25]
), ArticleFig(id=1322927725962462048, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322927719553565478, language=CN, label=表7, caption=

白花蛇舌草中的苯丙素和香豆素类化合物

, figureFileSmall=null, figureFileBig=null, tableContent=
序号化合物分子式参考文献
102秦皮甲素C15H16O9[10]
103东莨菪内酯C10H8O4[5]
104反式对羟基桂皮酸十八酯C27H44O3[31]
1057-羟基-6-甲氧基香豆素C10H8O4[31]
1067R,7'R,8S,8'S-(+)-新橄榄树脂素C20H24O7[25]
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白花蛇舌草研究进展及质量标志物(Q-Marker)的预测分析
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王华雨 1, 2 , 武鸣鸣 1, 2 , 王连睿 1, 2 , 苗明三 1, 2
中华中医药学刊 | 国家项目点击 2025,43(8): 159-166
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中华中医药学刊 |国家项目点击 2025 , 43 (8) : 159 -166
白花蛇舌草研究进展及质量标志物(Q-Marker)的预测分析
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王华雨(1999-),男,河南新乡人,硕士在读,研究方向:中药药理学。

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王华雨1, 2, 武鸣鸣1, 2, 王连睿1, 2, 苗明三1, 2
作者信息
  • 1.河南中医药大学,河南 郑州 450046
  • 2.河南中医药大学豫药全产业链研发河南省协同创新中心,河南 郑州 450046
通讯作者:
苗明三(1965-),男,河南新乡人,教授,博士研究生导师,博士,研究方向:中药药理学。E-mail:。
作者简介:

王华雨(1999-),男,河南新乡人,硕士在读,研究方向:中药药理学。

Research Progress and Prediction Analysis of Quality Markers(Q-Marker)of Baihuasheshecao(Hedyotidis Diffusae Herba)
Huayu WANG1, 2, Mingming WU1, 2, Lianrui WANG1, 2, Mingsan MIAO1, 2
Affiliations
  • 1.Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China
  • 2.Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao,Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China
出版时间: 2025-08-10 doi: 10.13193/j.issn.1673-7717.2025.08.031
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白花蛇舌草是我国传统中药,已有上千年历史,其化学成分多样,包含有黄酮类及其苷类、萜类、蒽醌类、甾体类、有机酸类、苯丙素和香豆素类等多种化学成分。现代研究表明,白花蛇舌草具有抗肿瘤、抗炎、抗菌、抗氧化以及免疫系统调节等药理作用。通过对白花蛇舌草的化学成分、药理作用进行总结,并根据中药质量标志物(quality Marker,QMarker)的概念,从植物亲缘学、传统药性和药效、化学成分溯源性、不同产地和采收时期、复方配伍以及化学成分可测性几个方面对白花蛇舌草的质量标志物进行分析预测,以期为建立全面科学的白花蛇舌草的质量控制体系提供依据。

白花蛇舌草  /  质量标志物  /  化学成分  /  药理作用

Baihuasheshecao(Hedyotidis Diffusae Herba)is a traditional Chinese medicine in China with a history of thousands of years,and its chemical composition is diverse,including flavonoids and their glycosides,terpenoids,anthraquinones,steroids,organic acids,phenylpropanin and coumarin.Modern studies have shown that Baihuasheshecao(Hedyotidis Diffusae Herba)has anti-tumor,anti-inflammatory,antibacterial,antioxidant and immune system modulation pharmacological effects.In this paper,the chemical composition and pharmacological effects of quality Marker(Q-Marker)were summarized,and according to the concept of Q-Marker,it analyzed and predicted the Q-Markers of Baihuasheshecao(Hedyotidis Diffusae Herba)from the aspects of plant genelogy,traditional medicinal properties and efficacy,chemical composition traceability,different origins and harvest periods,compound compatibility and chemical composition measurability,in order to provide a basis for the establishment of a comprehensive and scientific quality control system of Q-Marker.

Baihuasheshecao(Hedyotidis Diffusae Herba)  /  quality Markers  /  chemical composition  /  pharmacological effect
王华雨, 武鸣鸣, 王连睿, 苗明三. 白花蛇舌草研究进展及质量标志物(Q-Marker)的预测分析. 中华中医药学刊, 2025 , 43 (8) : 159 -166 . DOI: 10.13193/j.issn.1673-7717.2025.08.031
Huayu WANG, Mingming WU, Lianrui WANG, Mingsan MIAO. Research Progress and Prediction Analysis of Quality Markers(Q-Marker)of Baihuasheshecao(Hedyotidis Diffusae Herba)[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (8) : 159 -166 . DOI: 10.13193/j.issn.1673-7717.2025.08.031
白花蛇舌草为茜草科(Rubiaceae)耳草属(Hedyotis)植物白花蛇舌草Hedyotis diffusa Willd.的带根干燥全草,始载于《神农本草经》,又名蛇针草、蛇舌草、蛇舌癀等;其味苦甘,寒,无毒,归心、肝、脾经,具有清热、利湿、解毒的功效,可用于治疗肺热喘咳、阑尾炎、尿路感染、黄疸、毒蛇咬伤以及消化道癌症;夏、秋采收,晒干或鲜用;生长于山坡、路边、溪畔草丛中,主产于福建、广东、广西等地[1]。现代研究表明,白花蛇舌草具有抗肿瘤、抗衰老等药理作用[2],韦胤寰等[3]还发现,白花蛇舌草具有抗氧化活性、免疫调节以及负性心肌作用。《中华人民共和国药典》2020年版未收录白花蛇舌草原料药材,地方标准只有简单的性状、理化鉴别等,不能全面、系统有效地控制白花蛇舌草的质量。因此为了保证白花蛇舌草临床用药的安全性和有效性,亟需建立一个安全、系统有效的质量控制标准。本文通过查阅近年来白花蛇舌草的相关文献,对其化学成分、药理作用进行系统综述,并基于刘昌孝院士提出的中药质量标志物(qualitymarker,Q-Marker)概念,从植物亲缘学、传统药性和药效、化学成分溯源性、配伍以及化学成分可测性几方面对白花蛇舌草Q-Marker进行预测分析,以期为白花蛇舌草的质量控制及临床应用提供参考依据。
白花蛇舌草的化学成分极多,主要包括黄酮类、萜类、蒽醌类、甾醇类、多糖类、微量元素、氨基酸、挥发油等[4],现对其进行阐述。
白花蛇舌草中的黄酮及苷类化合物见表1。
白花蛇舌草中的三萜类化合物见表2。
白花蛇舌草中的环烯醚萜类化合物见表3。
白花蛇舌草中的蒽醌类化合物见表4。
白花蛇舌草中的甾体类化合物见表5。
白花蛇舌草中的含酸化合物见表6。
白花蛇舌草中的苯丙素和香豆素类化合物见表7。
除了上述成分外,白花蛇舌草中还含有多糖类、微量元素等其他成分。宝炉丹等[34]提取并研究了不同产地白花蛇舌草中的水溶性多糖,发现白花蛇舌草多糖由鼠李糖、葡萄糖、半乳糖、阿拉伯糖及甘露糖组成的杂多糖,其中葡萄糖含量最多。卑占宇等[35]用火焰原子吸收光谱法测定发现白花蛇舌草含有丰富的铁、铜、锌、锰、钙、镁,其含量相对于其他中草药含量较高。
研究表明[28]白花蛇舌草中的黄酮类、萜类、多糖类以及蒽醌类化合物具有良好的抗肿瘤作用,是白花蛇舌草中重要的抗肿瘤活性成分。
龙远熊等[36]基于网络药理学与分子对接技术探讨白花蛇舌草治疗鼻咽癌的作用机制,白花蛇舌草可能通过关键化合物槲皮素、β-谷甾醇、2-甲氧基-3-甲基-9,10-蒽醌,豆甾醇作用于TP53、血管内皮生长因子A(vascular endothelial growth factor A,VEGFA)、肿瘤坏死因子(tumor necrosis factor,TNF)、白细胞介素-6(interleukin-6,IL-6)等关键靶点,影响相关生物学过程与关键通路干预鼻咽癌的发生发展。
张子强等[37]研究发现,白花蛇舌草提取物可能通过磷脂酰肌醇3-激酶(phosphatidylin-ositol-3-kinase,PI3K)/蛋白激酶B(protein kinase B,AKT)/哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)信号通路激活而抑制肝癌术后感染大鼠促炎性因子表达,进而抑制感染,促进肝损伤修复。徐缘等[38]通过对半枝莲-白花蛇舌草治疗胃癌的作用机制的探讨,研究筛选出半枝莲-白花蛇舌草的35个有效成分和64个靶点有效成分,与其作用靶点形成互作网络,并调控关键信号通路来治疗胃癌。张其爱等[18]发现白花蛇舌草中的齐墩果酸和白桦脂酸对SW480和HT-29细胞的生长有一定的抑制作用,尤其是白桦脂酸在中高浓度时对肿瘤细胞的生长有显著抑制作用。
罗悦等[39]研究发现,白花蛇舌草中总黄酮提取物能抑制肺癌细胞的生长,孙晓春等[40]从白花蛇舌草中提取总黄酮、总蒽醌提取物,发现两种提取物对肺癌细胞A549均具有抗肿瘤活性;郭洪梅等[41]研究发现,白花蛇舌草水提物对人肺癌细胞株A549和PC-9细胞具有显著的剂量依赖的增殖抑制,促进细胞凋亡。
周兴波等[42]通过研究白花蛇舌草提取物对人肾癌780-O细胞在体外增殖及凋亡的影响,发现不同浓度的白花蛇舌草提取物通过调节PI3K/AKT信号通路,均能够抑制肾癌细胞的增殖,且随着药物浓度的提升,抑制作用逐渐增强。南锡浩等[43-44]发现白花蛇舌草提取物通过干扰细胞分化、增殖以及凋亡的主要途径Janus激酶2(recombinant Janus Kinase 2,JAK2)/信号转导和转录激活因子3通路(signal transducer and activator of transcription 3,STAT3)能够抑制人膀胱癌T24细胞株生长繁殖。冯懿赓等[45]发现白花蛇舌草提取物对人前列腺癌DU145细胞抑制率随着作用时间的延长和剂量的增加明显提高。
张焱等[46]发现一定浓度的白花蛇舌草处理后胶质瘤U87细胞凋亡率显著增加。其发挥作用的机制可能与白花蛇舌草干扰线粒体途径,能显著上调促凋亡蛋白酶切含半胱氨酸的天冬氨酸蛋白水解酶-3(cysteinyl aspartate specific proteinase-3,Caspase-3)、Bcl-2关联X蛋白(recombinant bcl2 associated X protein,βax)基因的表达并降低抗凋亡蛋白B淋巴细胞瘤-2(B-cell lymphoma-2,βcl-2)/βax比率有关,且白花蛇舌草中黄酮等抗肿瘤有效成分能通过血脑屏障,使得应用于胶质瘤临床治疗成为可能。
姚博文等[47]研究发现白花蛇舌草总黄酮能明显抑制乳腺癌恶性行为,并通过蛋白激酶B(prtein kinase B,AKT)/糖原合成酶激酶3β(glycogen synthase kinase-3β,GSK3β)/β-连环蛋白(beta catenin,β-catenin)通路明显降低其增殖活性和干性比例,促进其凋亡。王信林等[48]发现白花蛇舌草醇提物与半枝莲配伍能不同程度地抑制乳腺癌细胞株MCF-7细胞的增殖,且存在明显的剂量效应;王宇等[49]还发现白花蛇舌草提取物对人乳腺癌MCF-7细胞的增殖和凋亡都有抑制作用,且“量-效”关系显著。
白花蛇舌草在临床上是清热解毒的良药,是一种现代常用的抗炎中药,不良反应小,临床上单用或者配伍使用治疗各种炎症疾病[50]。李曼等[50]研究了白花蛇舌草的水提液和醇提液,发现两者都具有抗炎镇痛作用。CHEN Y L等[51]发现白花蛇舌草总黄酮可以通过抑制丝裂原活化蛋白激酶(mitogenactivated protein kinase,MAPK)和核因子激活的B细胞的κ-轻链增强(nuclear factor kappa-B,NF-κβ)的信号通路,显著抑制细胞炎性的NO、TNF-α、IL-6和IL-1β表达,增强巨噬细胞的吞噬作用。贾鹏等[52]通过实验表明白花蛇舌草可显著降低类风湿性关节炎大鼠的关节炎指数,刺激网状内皮细胞的吞噬能力,与对照组相比,白花蛇舌草各剂量组血清TNF-α、IL-1β、前列腺素E2(prostaglandin E2,PGE2)水平明显降低,抑制核因子κB受体活化因子配体(Receptor Activator of Nuclear Factor-κB Ligand,RANKL)、破骨细胞抑制因子(osteoclastogenesis inhibitory factor,OPG)、RANKL/OPG水平,从而达到治疗目的。
李建志等[53]研究表明,白花蛇舌草中药液具有良好的抗菌作用。边才苗等[54]研究了白花蛇舌草不同提取物(沸水、70%乙醇和60%丙酮)对金黄色葡萄球菌等的抑杀作用,结果显示白花蛇舌草不同提取物对4种菌均有明显的抑杀作用。曾俊等[55]经抑菌实验表明,白花蛇舌草醇提物以及纯化后的黄酮类化合物对枯草芽孢杆菌、大肠杆菌和金黄色葡萄球菌均有明显的抑菌作用,且抑制作用也随着浓度的升高而增强。蒋丹等[56]采用琼脂板扩散法对白花蛇舌草的醇提物进行了大肠杆菌、绿脓杆菌、金黄色葡萄球菌的敏感性试验,结果对3种细菌表现出较强的抑菌活性。
白花蛇舌草具有抗氧化抗衰老的作用。江燕妮等[2]发现白花蛇舌草中的乙醇、丙酮、氯仿等成分均有较强的抗氧化作用,其中,丙酮的抗氧化作用是最强的,白花蛇舌草中的有效成分,可提高超氧化物歧化酶活力,促进氧自由基清除,抑制脂质过氧化,从而抵抗衰老而延长寿命。杨新周等[57]提取白花蛇舌草中的黄酮、多酚、多糖类物质,并利用IC50评价提取物抗氧化能力,结果表明白花蛇舌草中功能抗氧化活性组分主要为黄酮和多酚。聂利华等[58]用白花蛇舌草的醇提取物给正常小鼠灌胃,给药两周后发现小鼠体内血清超氧化物歧化酶(superoxide dismutase,SOD)、肝脏及脑组织的抗氧化酶SOD、血清过氧化氢酶(catalase,CAT)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)及总抗氧化能力(total Antioxidant Capacity,T-AOC)活性均明显增强,血清、肝脏及脑组织中脂质过氧化产物丙二醛(malondialdehyde,MDA)均明显下降,说明白花蛇舌草醇提物能在一定程度上增强体内多种抗氧化酶活性,减少脂质过氧化的损伤程度,具有提高体内抗氧化活性的能力。
研究发现,白花蛇舌草中的活性成分能够增强患者的免疫力,具有免疫调节作用。王露瑶等[59]通过给小鼠注射白花蛇舌草注射液与正常对照组相比,荷瘤鼠细胞的免疫功能得到提高,β细胞介导的体液免疫功能也得到增强,从而提升了荷瘤鼠的综合免疫功能。瞿俊勇等[60]通过建立免疫抑制模型作为对照,从小鼠脏器系数、血清溶血素、淋巴细胞增殖、自然杀伤细胞(natural killer cell,NK)活性、细胞因子血清IL-2、IL-6、TNF-α含量等方面与给药白花蛇舌草组相比,实验结果表明白花蛇舌草多糖可显著提高免疫抑制小鼠的免疫功能。王雪等[61]发现白花蛇舌草总黄酮能够调节小鼠免疫细胞因子,维持1型辅助T细胞(T helper cell 1,Th1)/Th2(T helper cell 2,Th2)细胞平衡,改善机体免疫功能。张林超等[62]还发现,白花蛇舌草多糖可以通过增加免疫器官质量、提高小鼠淋巴细胞转化程度及增强小鼠C-型凝集素(C-type Lectins,CTL)杀伤活性来促进荷瘤小鼠免疫功能的提高。
质量标志物为刘昌孝院士于2016年提出的中药质控新概念,指存在于中药材和中药产品(中药饮片、中药煎剂、中药提取物、中成药制剂等)中固有或加工制备过程中形成的、与中药的功能属性密切相关的化学物质,作为反映中药安全性和有效性的标志性物质进行质量控制[63-64]。本文在Q-Marker概念的基础上对白花蛇舌草的Q-Marker进行分析,以期能够为建立白花蛇舌草科学完善的质量控制体系提供参考。
耳草属主要分布于热带和亚热带地区,少数分布于温带。我国有耳草属植物69种(包括7个变种),主要分布于长江流域及其以南各省区,北部极少[65]。耳草属主要含有环烯醚萜类、黄酮类、醌类、生物碱类等多种化学成分,具有抗炎、抗肿瘤、抗氧化、免疫调节等药理作用,与中药材白花蛇舌草化学成分和药理作用相似[66]。现代药理学研究发现,白花蛇舌草中重要的活性物质包括环烯醚萜类化合物,黄酮类化合物和蒽醌类化合物[67]。研究发现[68],(E)-6-0-P香豆酰鸡屎藤苷甲酯的含量最高,是白花蛇舌草的指标性化合物,具有较强的抗炎药理活性,且该研究建立了良好的测定该物质含量的方法学,能够更好地控制白花蛇舌草的质量。综上所述,可将(E)-6-0-P香豆酰鸡屎藤苷甲酯作为白花蛇舌草QMarker的重要参考。
中药药性理论是研究中药性质、性能及其运用规律的理论,也是指导中医临床用药的理论体系[69]。白花蛇舌草味苦、甘,性寒,归心、肝、脾经,具有清热解毒、消痛散结、利尿除湿的功效。传统五味理论认为,苦味药能清泄发散火热、燥湿坚阴,甘味药能补益和中、缓急止痛[70]。现代药理研究表明,苦味药中多含有苷类、蒽醌、黄酮等成分[71]。李锡岭等[72]认为甘味药具备补阴育阳、益气生血、缓急舒筋、缓和药力、调和诸药、淡渗利湿等功效。中药临床药理研究表明[73-75],寒凉性药物主要抑制机体能量和物质代谢,具有抗细菌、抗真菌作用,白花蛇舌草中含有的化学成分以苷类、萜类、黄酮类居多。综上所述,黄酮类、萜类、甾体类、糖类化合物可作为白花蛇舌草QMarker的重要参考。
现代中医药研究的核心内容之一是中药药效物质[76],中药的药效在一定程度上决定了中药的质量。现代研究表明[77],白花蛇舌草具有广泛的抗炎、抗菌、抗肿瘤等作用。HE JY等[78]通过研究发现,白花蛇舌草中的车叶草苷酸和车叶草苷可能通过调控抑制NF-κB和MAPK信号通路的相关蛋白而具有显著的抗炎活性。张其爱等[18]研究发现,化合物齐墩果酸和白桦脂酸对SW480和HT-29细胞的生长有一定抑制作用,尤其是白桦脂酸在中高浓度时对肿瘤细胞的生长有显著抑制作用。综上所述,车叶草苷酸、车叶草苷、齐墩果酸、白桦脂酸等成分可以考虑作为白花蛇舌草的Q-Maker。
入血成分及代谢产物是中药最终发挥作用的“效应成分”,能够更好地阐明中药药效物质基础及作用机制,是质量标志物确定的重要依据[79]。王淑等[80]采用超高效液相色谱-四级杆飞行时间质谱(ultra performance iquid chromatography-quadrupole-time of flight-Mass Spectrometry,UPLC-QTOF-MS)技术的血清代谢组学方法对结肠炎相关结肠癌小鼠血清进行分析,得到11条潜在靶标代谢通路和11种潜在生物标志物,其中涉及能量代谢的潜在生物标志物为烟酰胺、肌酸;涉及脂类代谢的潜在生物标志物为亚油酸、花生四烯酸、白三烯A4和α-亚麻酸;涉及氨基酸代谢的潜在生物标志物为L-酪氨酸、甘氨酸、瓜氨酸;涉及糖代谢的潜在生物标志物为肌肉肌醇。王钰等[81]采用UPLC-Q-TOF-MS技术分析大鼠灌胃白花蛇舌草代谢产物,明确了E-6-O-对香豆酰鸡屎藤苷甲酯的体内代谢过程及代谢衍生物。综上所述,烟酰胺、肌酸、亚油酸、花生四烯酸、白三烯A4和α-亚麻酸、L-酪氨酸、甘氨酸、瓜氨酸、肌肉肌醇和(E)-6-O-对香豆酰鸡屎藤苷甲酯具有溯源性,可作为白花蛇舌草潜在的Q-Marker依据。
中药材的产地和采收时期与其成分含量密切相关,是中药质量控制的关键环节[82]。丁建兰等[83]选取河南、四川、湖南、江西等不同产地的白花蛇舌草,采用高效液相色谱法(high performance liquid chromatography,HPLC)测定不同产地的白花蛇舌草中的去乙酰车叶草酸甲酯的含量,发现不同产地间的测量结果存在显著差异,其中四川地区的含量最高,河南、湖南含量较低,江西地区的含量最低。刘红等[84]采用HPLC方法对不同产地白花蛇舌草药材中东莨菪亭和耳草酮β含量进行测定,结果发现不同产地的白花蛇舌草中东莨菪亭和耳草酮β的含量有较大的差异,江西产白花蛇舌草药材中东莨菪亭和耳草酮β含量均高于其他产地,其次为湖北、安徽,广西产含量最低。吴燕等[85]也采用HPLC的方法测定不同产地白花蛇舌草中齐墩果酸的含量,结果发现江西产白花蛇舌草中齐墩果酸含量最高,河南产的含量最低。朱缨等[86]于2009年6月—10月定期采收药植园内的白花蛇舌草,用HPLC法对其槲皮素的含量进行测定,结果显示,在其生长期内槲皮素含量先逐步增多,在9月份含量最高,10月份含量相较于9月有所下降,在开花-结果中期含量比较高,这时候药材的产量也较大,10月后药材逐渐枯萎,产量下降。综合上述变化,建议白花蛇舌草的最佳采收期为8—9月。综上所述,可将去乙酰车叶草酸甲酯、齐墩果酸、熊果酸、东莨菪亭和耳草酮β等作为白花蛇舌草的Q-Marker筛选的重要对象。
中药复方由多种中药组合而成,每种中药具有不同的药性和功效。不同中药之间存在协同或相互促进的作用,通过复方配伍,可综合运用多种中药的优点,以达到更全面、更具有针对性的治疗手段,从而增强疗效,提高治疗效果[87]。在QMarker研究中,配伍环境占有非常重要的地位,是质量研究回归到中医药理论的必要条件[88]。白花蛇舌草-威灵仙药对具有抗癌作用,其治疗癌症的作用的物质基础与槲皮素、阿魏酸、恩贝林这3种活性成分密切相关,其机制可能与通过调节PI3K-AKT信号通路作用于癌症疾病的靶点,达到治疗癌症的目的[89]。白花蛇舌草-半枝莲药对已被广泛应用于乳腺癌[90]、结肠癌[91]、胶质瘤[92]、胃癌[93]、胰腺癌[94]等癌症的治疗研究,显示较好的抗肿瘤活性,网络药理学研究发现,白花蛇舌草-半枝莲药对具有槲皮素、鼠李素和两种黄酮类化合物4种重要的活性成分,槲皮素通过调节癌细胞细胞内活性氧(reactive oxygen species,ROS)[95]、PI3K/AKT[96]、MAPK/细胞外调节蛋白激酶1/2(extracellular regulated protein kinases,ERK1/2)[97]、NF-κB[95]途径发挥其对前列腺癌的抗癌作用,除此之外,其中的鼠李素通过抑制VEGF诱导的人脐静脉内皮细胞(human umbilical vein endothelial cells,HUVECs)中血管内皮细胞生长因子受体2(vascular endothelial growth factor receptor 2,VEGFR2)及其下游信号调节因子的磷酸化,从而在体内和体外直接抑制乳腺癌细胞MDA-Mβ-231的增殖[98]。而分子对接结果显示,白花蛇舌草和半枝莲药对的活性成分槲皮素和鼠李素与多个细胞凋亡相关核心靶基因如ESR1、CCND1和SRC成功对接,可作用于前列腺癌的多条信号通路,从而抑制前列腺癌的发生发展[99]。赵海含等[100]基于网络药理学研究发现,白花蛇舌草-半枝莲-卵巢癌共同靶点109个,且槲皮素、木犀草素、β-谷甾醇为主要有效成分,都能诱导卵巢癌细胞凋亡,从而起到治疗作用。综上所述,可将槲皮素、鼠李素、木犀草素、阿魏酸、恩贝林等化合物作为白花蛇舌草潜在的Q-Marker。
化学成分可测性是建立中药质量评价体系的必要前提和核心环节[101]。周冰等[102]利用气相色谱质谱法(gaschromatography-mass spectrometry,GC-MS)分析了白花蛇舌草中的脂溶性化学成分,结果分离出了50个化学组分峰,并鉴定出十六烷酸、角鲨烯、顺式-异油酸、亚油酸等40个化学成分。周艳红等[103]用HPLC法测定了3批白花蛇舌草中熊果酸、异熊果酸和对香豆酸的含量,发现3批样品中各化学成分的含量有所差异,且不同批次含有的最多化学成分亦不同。王勇等[104]用HPLC法测定了8批白花蛇舌草中东莨菪内酯和槲皮素的含量,发现8批样品中两者的含量均有所不同,湖北批次东莨菪内酯含量最高,而广东批次的槲皮素含量最高。王信等[105]建立了15批白花蛇舌草药材指纹图谱,共确认18个共有峰,通过高效液相色谱与电喷雾四极杆飞行时间质谱仪串联技术(high performance liquid chromatography - electrospray ionization-quadrupole-time of fly-mass spectrometry,HPLCESI-Q-TOF-MS)初步鉴定了12个色谱峰,并基于鉴定出的化合物运用网络药理学从有效性角度对其进行分析,发现(E)/(Z)-6-O-香豆酰鸡屎藤次苷甲酯、槲皮素-3-O-[2-O-(6-O-E-阿魏酰基)-β-D-吡喃葡糖苷]-β-D-吡喃半乳糖苷、(E)/(Z)-6-O-阿魏酰鸡屎藤次苷甲酯成分可作为白花蛇舌草潜在的Q-Marker。综上所述,可将熊果酸、异熊果酸、对香豆酸、槲皮素、东莨菪内酯等成分作为白花蛇舌草Q-Marker的参考依据。
白花蛇舌草作为我国传统中药,历史悠久,资源丰富,药理作用广泛,应用前景广阔。然而最新版中国药典并没有收载白花蛇舌草,地方标准只有简单的性状、理化鉴别等,亟待建立一个全面、系统有效的白花蛇舌草整体控制质量方法。
现代药理研究表明,白花蛇舌草具有广泛的药理活性,目前白花蛇舌草被证实具有多种抗肿瘤作用,但主要是体外研究,较少延伸至体内及临床研究,还需深入研究完善其抗肿瘤作用机制。同时,白花蛇舌草还有抗炎、抗病毒、调节免疫等多种作用,现研究仅对其有效性进行评价,作用机制研究相对不足,可结合液质联用等相关现代分析技术、网络药理学和分子对接技术等对其机制进行深入系统的研究。此外,白花蛇舌草中的多糖及铁、锰等微量元素的药理作用有待深入研究。
本文在刘昌孝院士提出的Q-Marker理论的指导下,通过对白花蛇舌草化学成分和药理作用进行总结,并将可以视为白花蛇舌草质量标志物的成分从植物亲缘学及化学成分特有性、传统药性和新的药效、化学成分溯源性、不同产地和采收时期、复方配伍和化学成分可测性等方面进行了系统的文献分析和总结,最终推测(E)-6-0-P香豆酰鸡屎藤苷甲酯、车叶草苷酸、车叶草苷、齐墩果酸、白桦脂酸、熊果酸等萜类化合物,槲皮素、鼠李素、木犀草素等黄酮类化合物,以及甾醇类、多糖类等成分作为白花蛇舌草的候选Q-Marker,为建立系统科学的白花蛇舌草的质量控制体系提供参考依据。总结还发现不同产地和采收时期的预测以及化学成分溯源性的预测最有应用价值。不同产地和采收时期的标志物的预测,可以为白花蛇舌草更高质量地种植采收提供依据,能够提高白花蛇舌草的药用质量;化学成分溯源性的质量标志物的预测可以为白花蛇舌草的临床用药提供指导依据,提高白花蛇舌草的临床药效。为保障白花蛇舌草的用药安全及临床疗效,建议后期对以上提出的候选成分进行深入研究,确定白花蛇舌草的有效化学成分及药理作用机制。
  • 国家中医药管理局联合开放课题(GZYKJS-2022-040-1)
  • 豫药全产业链研发河南省协同创新中心项目(豫科技〔2023〕175号)
  • 河南省重大专项(221100310400)
  • 河南省国际合作重点项目(231111521200)
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2025年第43卷第8期
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doi: 10.13193/j.issn.1673-7717.2025.08.031
  • 首发时间:2026-10-30
  • 出版时间:2025-08-10
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国家中医药管理局联合开放课题(GZYKJS-2022-040-1)
豫药全产业链研发河南省协同创新中心项目(豫科技〔2023〕175号)
河南省重大专项(221100310400)
河南省国际合作重点项目(231111521200)
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    1.河南中医药大学,河南 郑州 450046
    2.河南中医药大学豫药全产业链研发河南省协同创新中心,河南 郑州 450046

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苗明三(1965-),男,河南新乡人,教授,博士研究生导师,博士,研究方向:中药药理学。E-mail:。
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2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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