Article(id=1322926462646497579, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.08.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339847479, onlineDateStr=2026-10-30, pubDate=1754755200000, pubDateStr=2025-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339847479, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339847479, creator=13701087609, updateTime=1793339847479, updator=13701087609, issue=Issue{id=1322926217711726961, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='8', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1754755200000', pubDateStr='2025-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339789083, creator='13701087609', updateTime=1793340517761, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929274071679978, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929274071679979, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322926217711726961, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=40, endPage=43, ext={EN=ArticleExt(id=1322926462835241260, articleId=1322926462646497579, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Clinical Observation of Qisheng Gushen Decoction（芪参固肾汤）Combined with Irbesartan in Treatment of Chronic Kidney Disease at Stage 2-3, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the clinical effect of Qisheng Gushen Decoction（芪参固肾汤）combined with irbesartan in the treatment of chronic kidney disease at stage 2～3.
Methods A total of 110 patients with chronic kidney disease at stage 2～3（admitted from August 2021 to October 2023）were divided into decoction group and western medicine group by random number table method，with 55 cases in each group.The western medicine group received irbesartan and other western medicines，and the decoction group was treated with Qisheng Gushen Decoction on the basis of the western medicine group.In the course of treatment，1 case was shed in the western medicine group and 2 cases were shed in the decoction group.The data of each group was observed as follows：curative effect，integral changes of TCM symptoms（main disease and secondary disease）before and after treatment，changes of renal function indicators，changes of inflammatory factors indicators，changes of intestinal flora，changes of T lymphocyte subsets and other immune function indicators，adverse reactions.
Results The total effective rate of the decoction group was significantly higher than that of the western medicine group（P<0.05）.After treatment，the scores of TCM syndrome（main disease and secondary disease），24-hour urinary protein quantification（24 h-UTP），serum creatinine（SCr），urea nitrogen（BUN），albumin（ALB），estimated glomerular filtration rate（eGFR），interleukin-6（IL-6），interleukin-17（IL-17）and hypersensitive C-reactive protein（hs-CRP），intestinal flora indicators such as Lactobacillus acidophilus，bifidobacterium and Escherichia coli，and immune indicators such as T lymphocyte subsets（CD3+，CD4+，CD8+，CD4+/CD8+）were improved.In the decoction group，these indexes were all better than those in western medicine group（P<0.05）.The total adverse reaction rate of the decoction group was lower than that of the western medicine group（P<0.05）.
Conclusion Qisheng Gushen Decoction combined with irbesartan in the treatment of chronic kidney disease at stage 2～3 can regulate the immune function，improve the renal function，immune function and inflammatory response of patients，enhance the therapeutic effect，and reduce adverse reactions，and the treatment is safe and reliable.
, authors=Wei TIAN, Chenxia JUN, Qiuli WANG, Dongji WANG, authorsList=Wei TIAN, Chenxia JUN, Qiuli WANG, Dongji WANG, authorCompany=null, correspAuthors=Dongji WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322926465741893943, articleId=1322926462646497579, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=芪参固肾汤结合厄贝沙坦治疗2～3期慢性肾脏病临床观察, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 探讨芪参固肾汤结合厄贝沙坦治疗2～3期慢性肾脏病临床效果。
方法 研究总计纳入110例2～3期慢性肾脏病患者，采取随机数字表法将患者分为汤剂组与西药组，每组55例，西药组患者采取厄贝沙坦等西药常规治疗，汤剂组患者在西药组用药基础上结合中药芪参固肾汤治疗，治疗过程中西药组脱落1例，汤剂组脱落2例。观察各组数据情况：疗效、治疗前后中医证候（主症、次症）积分变化、肾功能相关指标变化、炎症因子指标变化以及肠道菌群变化、T淋巴细胞亚群等免疫功能指标变化、不良反应。
结果 汤剂组治疗总有效率显著高于西药组（P<0.05）；治疗后各组患者中医证候（主症、次症）积分、24 h尿蛋白定量（24-hour urinary protein quantification，24 h-UTP）、血肌酐（blood creatinine，SCr）、尿素氮（urea nitrogen，BUN）、白蛋白（albumin，ALB）、肾小球过滤率估计值（estimated glomerular filtration Rate，eGFR）等肾功能相关指标、白细胞介素-6（interleukin 6，IL-6）及白细胞介素-17（interleukin 17，IL-17）、超敏C反应蛋白（hypersensitive C-reactive protein，hs-CRP）等炎症因子指标、嗜酸乳杆菌及双歧杆菌、大肠杆菌等肠道菌群指标、T淋巴细胞亚群（CD3+、CD4+、CD8+、CD4+/CD8+）等免疫指标均改善，而汤剂组患者治疗后中医证候（主症、次症）积分、肾功能相关指标（24 h-UTP、SCr、BUN、ALB、eGFR）、炎症因子指标（IL-6、IL-17、hs-CRP）、肠道菌群（嗜酸乳杆菌及双歧杆菌、大肠杆菌）、T淋巴细胞亚群（CD3+、CD4+、CD8+、CD4+/CD8+）等指标均优于西药组，P<0.05；汤剂组治疗总不良反应率比西药组更低（P<0.05）。
结论 芪参固肾汤结合厄贝沙坦治疗2～3期慢性肾脏病可调节患者免疫功能，改善患者肾功能及免疫功能、炎症反应，提升治疗效果，且降低不良反应，治疗安全可靠。
, authors=田卫, 隽晨霞, 王求利, 王东济, authorsList=田卫, 隽晨霞, 王求利, 王东济, authorCompany=null, correspAuthors=王东济, authorNote=
田卫（1985-），男，江苏连云港人，副主任中医师，硕士，研究方向：糖尿病及其并发症的诊治。
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田卫（1985-），男，江苏连云港人，副主任中医师，硕士，研究方向：糖尿病及其并发症的诊治。
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广州中医药大学学报，
2023，
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中国中医药信息杂志，
2023，
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广州中医药大学学报，
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现代中西医结合杂志，
2023，
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宁夏医科大学学报，
2023，
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现代中西医结合杂志，
2023，
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天津中医药，
2022，
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现代中医临床，
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中国中西医结合肾病杂志，
2023，
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中国医药导报，
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国际泌尿系统杂志，
2022，
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中华肾脏病杂志，
2022，
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中国中西医结合肾病杂志，
2023，
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现代中西医结合杂志，
2022，
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上海中医药杂志，
2022，
56（10）：8-12., articleTitle=慢性肾脏病患者新型冠状病毒奥密克戎变异株感染后中医证候特征调查研究, refAbstract=null), Reference(id=1322926472398254462, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, doi=null, pmid=null, pmcid=null, year=2022, volume=23, issue=8, pageStart=662, pageEnd=664, url=null, language=null, rfNumber=［19］, rfOrder=18, authorNames=胡天祥, 卢家言, 曾露, journalName=中国中西医结合肾病杂志, refType=null, unstructuredReference=胡天祥，卢家言，曾露，
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中国中西医结合肾病杂志，
2022，
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中华中医药杂志，
2022，
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中国中药杂志，
2022，
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时珍国医国药，
2023，
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中华中医药学刊，
2022，
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国际中医中药杂志，
2023，
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临床肾脏病杂志，
2022，
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中国中西医结合肾病杂志，
2023，
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中国中西医结合肾病杂志，
2022，
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20（6）：128-131., articleTitle=周恩超教授治疗慢性肾脏病常用药组探析, refAbstract=null), Reference(id=1322926475103580552, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, doi=null, pmid=null, pmcid=null, year=2022, volume=19, issue=14, pageStart=133, pageEnd=137, url=null, language=null, rfNumber=［29］, rfOrder=28, authorNames=李虎才, 林俊杰, 何志仁, journalName=中国医药导报, refType=null, unstructuredReference=李虎才，林俊杰，何志仁，
等. 基于数据挖掘的国医大师张大宁治疗慢性肾脏病用药规律分析［J］.
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42（3）：253-258., articleTitle=南征教授运用药对治疗慢性肾脏病经验, refAbstract=null)], funds=[Fund(id=1322926470892499307, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, awardId=82100753, language=CN, fundingSource=国家自然科学基金项目(82100753), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322926466043883832, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, xref=null, ext=[AuthorCompanyExt(id=1322926466056466745, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, companyId=1322926466043883832, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Lianyungang Traditional Chinese Medicine Hospital，Lianyungang 222000，Jiangsu，China), AuthorCompanyExt(id=1322926466064855354, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, companyId=1322926466043883832, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=连云港市中医院，江苏 连云港 222000)])], figs=[ArticleFig(id=1322926468317196637, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 西药组 | 54 | 24 | 18 | 12 | 42（77.78） |
| 汤剂组 | 53 | 39 | 10 | 4 | 49（92.45） |
| χ2值 | | - | - | - | 4.529 5 |
| P值 | | - | - | - | 0.033 3 |
), ArticleFig(id=1322926469911032158, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, language=CN, label=表1, caption=
两组2~3期慢性肾脏病患者临床疗效比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 西药组 | 54 | 24 | 18 | 12 | 42（77.78） |
| 汤剂组 | 53 | 39 | 10 | 4 | 49（92.45） |
| χ2值 | | - | - | - | 4.529 5 |
| P值 | | - | - | - | 0.033 3 |
), ArticleFig(id=1322926469986529631, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗时间 | 主症 | 次症 |
|---|
| 西药组 | 54 | 治疗前 | 21.23±1.24 | 12.15±0.74 |
| | 治疗后 | 6.34±1.00* | 3.25±0.26* |
| 汤剂组 | 53 | 治疗前 | 21.09±1.30 | 12.19±0.80 |
| | 治疗后 | 2.48±0.85*# | 1.85±0.16*# |
), ArticleFig(id=1322926470053638496, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, language=CN, label=表2, caption=
两组2~3期慢性肾脏病患者治疗前后中医证候积分变化比较（
）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗时间 | 主症 | 次症 |
|---|
| 西药组 | 54 | 治疗前 | 21.23±1.24 | 12.15±0.74 |
| | 治疗后 | 6.34±1.00* | 3.25±0.26* |
| 汤剂组 | 53 | 治疗前 | 21.09±1.30 | 12.19±0.80 |
| | 治疗后 | 2.48±0.85*# | 1.85±0.16*# |
), ArticleFig(id=1322926470145913185, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗时间 | 24 h-UTP/（g） | SCr/（μmol/L） | BUN/（mmol/L） | ALB/（g/L） | eGFR/［mL/（min·1.73 m2）］ |
|---|
| 西药组 | 54 | 治疗前 | 1.92±0.35 | 280.42±15.23 | 15.44±2.85 | 28.34±2.03 | 60.27±10.65 |
| | 治疗后 | 1.22±0.16* | 170.45±10.62* | 11.54±2.02* | 37.39±3.15* | 67.52±8.23* |
| 汤剂组 | 53 | 治疗前 | 1.91±0.26 | 280.39±14.99 | 15.45±2.90 | 28.29±2.00 | 60.24±10.59 |
| | 治疗后 | 0.85±0.13*# | 130.52±9.62*# | 9.28±1.65*# | 41.29±3.16*# | 76.39±8.35*# |
), ArticleFig(id=1322926470213022050, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, language=CN, label=表3, caption=
两组2~3期慢性肾脏病患者治疗前后肾功能相关指标变化比较（
）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗时间 | 24 h-UTP/（g） | SCr/（μmol/L） | BUN/（mmol/L） | ALB/（g/L） | eGFR/［mL/（min·1.73 m2）］ |
|---|
| 西药组 | 54 | 治疗前 | 1.92±0.35 | 280.42±15.23 | 15.44±2.85 | 28.34±2.03 | 60.27±10.65 |
| | 治疗后 | 1.22±0.16* | 170.45±10.62* | 11.54±2.02* | 37.39±3.15* | 67.52±8.23* |
| 汤剂组 | 53 | 治疗前 | 1.91±0.26 | 280.39±14.99 | 15.45±2.90 | 28.29±2.00 | 60.24±10.59 |
| | 治疗后 | 0.85±0.13*# | 130.52±9.62*# | 9.28±1.65*# | 41.29±3.16*# | 76.39±8.35*# |
), ArticleFig(id=1322926470288519523, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗时间 | IL-6/（ng/L） | IL-17/（ng/L） | hs-CRP/（mg/L） |
|---|
| 西药组 | 54 | 治疗前 | 195.35±16.23 | 112.63±9.52 | 8.28±0.84 |
| | 治疗后 | 153.23±10.23* | 67.23±7.62* | 6.45±0.56* |
| 汤剂组 | 53 | 治疗前 | 195.29±15.98 | 112.58±9.60 | 8.31±0.79 |
| | 治疗后 | 133.26±8.62*# | 38.65±8.34*# | 3.39±0.39*# |
), ArticleFig(id=1322926470372405604, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, language=CN, label=表4, caption=
两组2~3期慢性肾脏病患者治疗前后炎症因子指标变化比较（
）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗时间 | IL-6/（ng/L） | IL-17/（ng/L） | hs-CRP/（mg/L） |
|---|
| 西药组 | 54 | 治疗前 | 195.35±16.23 | 112.63±9.52 | 8.28±0.84 |
| | 治疗后 | 153.23±10.23* | 67.23±7.62* | 6.45±0.56* |
| 汤剂组 | 53 | 治疗前 | 195.29±15.98 | 112.58±9.60 | 8.31±0.79 |
| | 治疗后 | 133.26±8.62*# | 38.65±8.34*# | 3.39±0.39*# |
), ArticleFig(id=1322926470435320165, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗时间 | 嗜酸乳杆菌 | 双歧杆菌 | 大肠杆菌 |
|---|
| 西药组 | 54 | 治疗前 | 6.72±0.22 | 7.41±0.59 | 10.39±0.66 |
| | 治疗后 | 8.74±0.56* | 9.40±0.36* | 8.67±0.45* |
| 汤剂组 | 53 | 治疗前 | 6.71±0.24 | 7.39±0.60 | 10.41±0.64 |
| | 治疗后 | 9.22±0.51*# | 9.85±0.34*# | 8.22±0.44*# |
), ArticleFig(id=1322926470498234726, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, language=CN, label=表5, caption=
两组2~3期慢性肾脏病患者治疗前后肠道菌群变化比较（
）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗时间 | 嗜酸乳杆菌 | 双歧杆菌 | 大肠杆菌 |
|---|
| 西药组 | 54 | 治疗前 | 6.72±0.22 | 7.41±0.59 | 10.39±0.66 |
| | 治疗后 | 8.74±0.56* | 9.40±0.36* | 8.67±0.45* |
| 汤剂组 | 53 | 治疗前 | 6.71±0.24 | 7.39±0.60 | 10.41±0.64 |
| | 治疗后 | 9.22±0.51*# | 9.85±0.34*# | 8.22±0.44*# |
), ArticleFig(id=1322926470577926503, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗时间 | CD3+ | CD4+ | CD8+ | CD4+/CD8+ |
|---|
| 西药组 | 54 | 治疗前 | 52.16±3.42 | 33.29±2.67 | 31.26±2.55 | 1.07±0.14 |
| | 治疗后 | 57.34±2.85* | 36.49±2.02* | 27.65±2.16* | 1.32±0.24* |
| 汤剂组 | 53 | 治疗前 | 52.14±3.39 | 33.31±2.59 | 31.24±2.49 | 1.05±0.12 |
| | 治疗后 | 59.45±2.21*# | 38.64±1.85*# | 26.34±2.22*# | 1.49±0.20*# |
), ArticleFig(id=1322926470653423976, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, language=CN, label=表6, caption=
两组2~3期慢性肾脏病患者治疗前后T淋巴细胞亚群变化比较（
）
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| 组别 | 例数 | 治疗时间 | CD3+ | CD4+ | CD8+ | CD4+/CD8+ |
|---|
| 西药组 | 54 | 治疗前 | 52.16±3.42 | 33.29±2.67 | 31.26±2.55 | 1.07±0.14 |
| | 治疗后 | 57.34±2.85* | 36.49±2.02* | 27.65±2.16* | 1.32±0.24* |
| 汤剂组 | 53 | 治疗前 | 52.14±3.39 | 33.31±2.59 | 31.24±2.49 | 1.05±0.12 |
| | 治疗后 | 59.45±2.21*# | 38.64±1.85*# | 26.34±2.22*# | 1.49±0.20*# |
), ArticleFig(id=1322926470724727145, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 恶心呕吐 | 腹胀腹泻 | 头痛 | 总不良反应 |
|---|
| 西药组 | 54 | 4 | 2 | 1 | 7（12.96） |
| 汤剂组 | 53 | 1 | 0 | 0 | 1（1.89） |
| χ2值 | | | | | 4.743 6 |
| P值 | | | | | 0.029 4 |
), ArticleFig(id=1322926470787641706, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926462646497579, language=CN, label=表7, caption=
两组2~3期慢性肾脏病患者治疗不良反应比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 恶心呕吐 | 腹胀腹泻 | 头痛 | 总不良反应 |
|---|
| 西药组 | 54 | 4 | 2 | 1 | 7（12.96） |
| 汤剂组 | 53 | 1 | 0 | 0 | 1（1.89） |
| χ2值 | | | | | 4.743 6 |
| P值 | | | | | 0.029 4 |
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