Article(id=1322926152372854992, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322925862630339452, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.07.044, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339773504, onlineDateStr=2026-10-30, pubDate=1752076800000, pubDateStr=2025-07-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339773504, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339773504, creator=13701087609, updateTime=1793339773504, updator=13701087609, issue=Issue{id=1322925862630339452, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='7', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1752076800000', pubDateStr='2025-07-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339704424, creator='13701087609', updateTime=1793340532184, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929334587105328, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322925862630339452, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929334587105329, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322925862630339452, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=221, endPage=224, ext={EN=ArticleExt(id=1322926152947474641, articleId=1322926152372854992, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Observation of Suhuang Zhike Capsule（苏黄止咳胶囊）in Treating Post-thyroidectomy Cough, columnId=1256183365644968140, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Platform of Provincial Project, runingTitle=null, highlight=null, articleAbstract=
Objective To discuss the clinical effect and safety observation of Suhuang Zhike Capsule（苏黄止咳胶囊）in treating post-thyroidectomy cough.
Methods Two hundred and three patients with post-thyroidectomy cough admitted from January 2021 to September 2023 were included，and assigned into two groups using random number table methods. The control group（101 cases）was given ambroxol aerosol inhalation，while the observation group（102 cases）was given ambroxol aerosol inhalation and Suhuang Zhike Capsule. The treatment in both groups lasted for 7 days. During treatment，2 cases in the observation group and 0 case in the control group were dropped out. Then the clinical efficacy，postoperative cough relief time，postoperative cough disappearance time，daytime cough symptom，nighttime cough symptom，Leicester Cough Questionnaire in Mandarin Chinese（LCQMC），self-rating anxiety scale（SAS），self-rating depression scale（SDS），immunoglobulin-related indexes，Karnofsky performance status scale（KPS）and adverse reactions were compared between two groups.
Results The observation group reported a higher clinical efficacy rate than the control group［97.00%（97/100）vs 90.10%（91/101），P<0.05］.the observation group showed decreased time to the relief and disappearance of postoperative cough，and had lower daytime and nighttime cough symptom scores compared to the control group（P<0.05）. After treatment，an increase in LCQ-MC score，immunoglobulin-related indexes and KPSscore，as well as a reduction in SASand SDSwere observed in all patients，and both changes were more notable in the observation group than those in the control group（P<0.05）. Both groups yielded a low adverse reaction rate，with no statistical difference（P>0.05）.
Conclusion Application of Suhuang Zhike Capsule in treating post-thyroidectomy cough can effectively improve immune function and quality of life，which has little adverse reaction and good safety.
, authors=Bo XU, Jingzhou ZHENG, Xiancai XIANG, Ming ZHANG, Ze ZHANG, authorsList=Bo XU, Jingzhou ZHENG, Xiancai XIANG, Ming ZHANG, Ze ZHANG, authorCompany=null, correspAuthors=Ze ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322926155866710238, articleId=1322926152372854992, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=苏黄止咳胶囊治疗甲状腺术后咳嗽临床观察, columnId=1256183369033965799, journalTitle=中华中医药学刊, columnName=省级项目平台, runingTitle=null, highlight=null, articleAbstract=
目的 探讨甲状腺术后咳嗽患者应用苏黄止咳胶囊治疗的临床效果及用药安全性。
方法 纳入203例甲状腺术后咳嗽患者（2021年1月—2023年9月收治）以随机数字表法分为观察组（102例）和对照组（101例），对照组术后给予盐酸氨溴索雾化治疗，观察组则术后给予盐酸氨溴索雾化及苏黄止咳胶囊治疗，两组患者疗程均为7 d。治疗过程中观察组脱落2例，对照组未见脱落。观察各组患者数据情况：临床疗效、术后咳嗽缓解时间以及术后咳嗽消失时间、患者日间咳嗽症状积分以及夜间咳嗽症状积分、治疗前后各组患者中文版的莱切斯特咳嗽量表（Leicester cough questionnaire in Mandarin-Chinese，LCQ-MCL）评分变化与焦虑自评（Self-rating anxiety scale，SAS）、抑郁自评量表（Self-rating depression scale，SDS）评分变化、免疫球蛋白相关指标变化、生活质量（Karnofsky performance scale，KPS）评分变化、治疗不良反应。
结果 治疗总有效率方面，观察组及对照组分别是97.00%（97/100）、90.10%（91/101），前者更高，P<0.05；观察组术后咳嗽缓解时间以及术后咳嗽消失时间均比对照组更短，日间咳嗽症状积分以及夜间咳嗽症状积分均比对照组更低，P<0.05；治疗后各组患者LCQ-MCL评分、免疫球蛋白相关指标、KPS评分均提升，SAS及SDS评分均下降，观察组患者治疗后LCQ-MCL评分、免疫球蛋白相关指标、KPS评分均高于对照组患者，SAS及SDS评分低于对照组患者，P<0.05；两组患者治疗不良反应率均较低，P>0.05。
结论 苏黄止咳胶囊治疗甲状腺术后咳嗽临床效果显著，患者症状改善，免疫功能以及生活质量均提升，不良反应少，治疗安全可靠。
, authors=许波, 郑荆洲, 向先才, 张明, 张泽, authorsList=许波, 郑荆洲, 向先才, 张明, 张泽, authorCompany=null, correspAuthors=张泽, authorNote=
许波（1984-），男（土家族），湖北宣恩人，主治医师，硕士，研究方向：甲状腺乳腺外科疾病的诊疗。
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许波（1984-），男（土家族），湖北宣恩人，主治医师，硕士，研究方向：甲状腺乳腺外科疾病的诊疗。
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许波（1984-），男（土家族），湖北宣恩人，主治医师，硕士，研究方向：甲状腺乳腺外科疾病的诊疗。
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articleId=1322926152372854992, language=CN, orderNo=3, keyword=临床效果), Keyword(id=1322926159578669317, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, language=CN, orderNo=4, keyword=不良反应), Keyword(id=1322926159658361094, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, language=CN, orderNo=5, keyword=免疫功能), Keyword(id=1322926159729664263, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, language=CN, orderNo=6, keyword=生活质量)], refs=[Reference(id=1322926161172504857, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, doi=null, pmid=null, pmcid=null, year=2023, volume=23, issue=7, pageStart=502, pageEnd=506, url=null, language=null, rfNumber=［1］, rfOrder=0, authorNames=曾焕虹, 黄东航, journalName=中国微创外科杂志, refType=null, unstructuredReference=曾焕虹，黄东航. 颈前入路充气法单孔腔镜辅助甲状腺手术与传统开放手术的对比研究［J］.
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现代肿瘤医学，
2023，
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中国超声医学杂志，
2023，
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中国老年学杂志，
2023，
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腹腔镜外科杂志，
2023，
28（3）：181-185，190., articleTitle=开放手术与完全腔镜手术治疗早期甲状腺乳头状癌的淋巴结清扫效果对比分析, refAbstract=null), Reference(id=1322926161566769438, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, doi=null, pmid=null, pmcid=null, year=2023, volume=null, issue=1, pageStart=60, pageEnd=63, url=null, language=null, rfNumber=［6］, rfOrder=5, authorNames=李朋, 梁青壮, 王东来, journalName=临床外科杂志, refType=null, unstructuredReference=李朋，梁青壮，王东来，
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临床外科杂志，
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中华地方病学杂志，
2022，
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中华内分泌外科杂志，
2023，
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中国医药，
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中国现代普通外科进展，
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中国普通外科杂志，
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中华结核和呼吸杂志，
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临床肺科杂志，
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中南大学学报（医学版），
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湖南中医药大学学报，
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中国药物应用与监测，
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中医药学报，
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中国中医基础医学杂志，
2023，
29（6）：1029-1031., articleTitle=甲状腺术后甲状旁腺功能减退症的中医辨治思路, refAbstract=null), Reference(id=1322926164225958189, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, doi=null, pmid=null, pmcid=null, year=2023, volume=36, issue=11, pageStart=946, pageEnd=954, url=null, language=null, rfNumber=［20］, rfOrder=19, authorNames=翟东亮, 朱见, 王丹, journalName=肿瘤预防与治疗, refType=null, unstructuredReference=翟东亮，朱见，王丹，
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肿瘤预防与治疗，
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中华内分泌外科杂志，
2023，
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天津中医药，
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39（4）：474-477., articleTitle=从中医整体观谈甲状腺癌的防治, refAbstract=null), Reference(id=1322926164418896176, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, doi=null, pmid=null, pmcid=null, year=2022, volume=25, issue=6, pageStart=755, pageEnd=758, url=null, language=null, rfNumber=［23］, rfOrder=22, authorNames=连心逸, 倪青, 苏宁, journalName=中国临床保健杂志, refType=null, unstructuredReference=连心逸，倪青，苏宁，
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中国临床保健杂志，
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中国中医药信息杂志，
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护理学报，
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中国肿瘤生物治疗杂志，
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中医肿瘤学杂志，
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江苏中医药，
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53（4）：54-56., articleTitle=行气活血法治疗甲状腺癌术后并发症心得, refAbstract=null), Reference(id=1322926164825743670, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, doi=null, pmid=null, pmcid=null, year=2022, volume=31, issue=20, pageStart=2841, pageEnd=2844, url=null, language=null, rfNumber=［29］, rfOrder=28, authorNames=汪晓露, 赵勇, 左新河, journalName=现代中西医结合杂志, refType=null, unstructuredReference=汪晓露，赵勇，左新河，
等. 左新河运用中医药治疗甲状腺结节热消融术后经验［J］.
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西部中医药，
2023，
36（5）：105-107., articleTitle=益气养阴散结方对甲状腺癌术后患者免疫功能的影响, refAbstract=null)], funds=[Fund(id=1322926161076035864, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, awardId=0968154, language=CN, fundingSource=湖北省科技厅科技项目(0968154), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322926156139339999, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, xref=null, ext=[AuthorCompanyExt(id=1322926156147728608, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, companyId=1322926156139339999, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Minda Hospital Affiliated to Hubei Minzu University，Enshi 445000，Hubei，China), AuthorCompanyExt(id=1322926156156117217, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, companyId=1322926156139339999, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖北民族大学附属民大医院，湖北 恩施 445000)])], figs=[ArticleFig(id=1322926159876464904, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 对照组 | 101 | 59 | 32 | 10 | 91（90.10） |
| 观察组 | 100 | 78 | 19 | 3 | 97（97.00） |
| χ2值 | | | | | 3.955 8 |
| P值 | | | | | 0.046 7 |
), ArticleFig(id=1322926159947768073, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, language=CN, label=表1, caption=
两组甲状腺术后咳嗽患者疗效对比
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| 组别 | 例数 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 对照组 | 101 | 59 | 32 | 10 | 91（90.10） |
| 观察组 | 100 | 78 | 19 | 3 | 97（97.00） |
| χ2值 | | | | | 3.955 8 |
| P值 | | | | | 0.046 7 |
), ArticleFig(id=1322926160023265546, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 术后咳嗽缓解时间 | 术后咳嗽消失时间 |
|---|
| 对照组 | 101 | 2.02±0.25 | 4.85±0.11 |
| 观察组 | 100 | 1.21±0.17* | 3.95±0.15* |
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两组甲状腺术后咳嗽患者术后咳嗽缓解时间与术后咳嗽消失时间对比（
±s）
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| 组别 | 例数 | 术后咳嗽缓解时间 | 术后咳嗽消失时间 |
|---|
| 对照组 | 101 | 2.02±0.25 | 4.85±0.11 |
| 观察组 | 100 | 1.21±0.17* | 3.95±0.15* |
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| 组别 | 例数 | 日间咳嗽症状积分 | 夜间咳嗽症状积分 |
|---|
| 对照组 | 101 | 1.76±0.15 | 1.89±0.14 |
| 观察组 | 100 | 1.10±0.11* | 1.15±0.20* |
), ArticleFig(id=1322926160212009229, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, language=CN, label=表3, caption=
两组甲状腺术后咳嗽患者日间及夜间咳嗽症状积分对比（
±s）
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| 组别 | 例数 | 日间咳嗽症状积分 | 夜间咳嗽症状积分 |
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| 对照组 | 101 | 1.76±0.15 | 1.89±0.14 |
| 观察组 | 100 | 1.10±0.11* | 1.15±0.20* |
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| 组别 | 例数 | 治疗时间 | 心理 | 生理 | 社会 | 总分 |
|---|
| 对照组 | 101 | 治疗前 | 19.45±2.15 | 20.34±2.65 | 22.39±3.36 | 61.95±2.64 |
| | 治疗后 | 25.34±1.85* | 27.64±3.12* | 27.63±3.06* | 79.73±2.31* |
| 观察组 | 100 | 治疗前 | 19.52±2.08 | 20.29±2.74 | 22.43±3.40 | 61.89±2.73 |
| | 治疗后 | 31.24±1.55*# | 30.29±1.99*# | 31.25±2.85*# | 92.15±3.10*# |
), ArticleFig(id=1322926160350421263, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, language=CN, label=表4, caption=
两组甲状腺术后咳嗽患者LCQ-MCL评分对比（
±s）
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| 组别 | 例数 | 治疗时间 | 心理 | 生理 | 社会 | 总分 |
|---|
| 对照组 | 101 | 治疗前 | 19.45±2.15 | 20.34±2.65 | 22.39±3.36 | 61.95±2.64 |
| | 治疗后 | 25.34±1.85* | 27.64±3.12* | 27.63±3.06* | 79.73±2.31* |
| 观察组 | 100 | 治疗前 | 19.52±2.08 | 20.29±2.74 | 22.43±3.40 | 61.89±2.73 |
| | 治疗后 | 31.24±1.55*# | 30.29±1.99*# | 31.25±2.85*# | 92.15±3.10*# |
), ArticleFig(id=1322926160417530128, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗时间 | SAS评分 | SDS评分 |
|---|
| 对照组 | 101 | 治疗前 | 51.00±4.23 | 54.23±6.23 |
| | 治疗后 | 42.32±5.23* | 43.27±4.41* |
| 观察组 | 100 | 治疗前 | 51.29±3.99 | 54.18±6.19 |
| | 治疗后 | 38.16±2.83*# | 37.84±3.64*# |
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两组甲状腺术后咳嗽患者SAS、SDS评分对比（
±s）
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| 组别 | 例数 | 治疗时间 | SAS评分 | SDS评分 |
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| 对照组 | 101 | 治疗前 | 51.00±4.23 | 54.23±6.23 |
| | 治疗后 | 42.32±5.23* | 43.27±4.41* |
| 观察组 | 100 | 治疗前 | 51.29±3.99 | 54.18±6.19 |
| | 治疗后 | 38.16±2.83*# | 37.84±3.64*# |
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| 组别 | 例数 | 治疗时间 | IgA | IgG | IgM |
|---|
| 对照组 | 101 | 治疗前 | 4.00±0.27 | 9.95±1.54 | 12.25±1.11 |
| | 治疗后 | 6.31±0.21* | 15.07±1.00* | 18.63±1.02* |
| 观察组 | 100 | 治疗前 | 3.98±0.30 | 9.98±1.60 | 12.30±1.05 |
| | 治疗后 | 10.49±0.25* | #2.85±1.13*# | 23.26±1.00*# |
), ArticleFig(id=1322926160677576979, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, language=CN, label=表6, caption=
两组甲状腺术后咳嗽患者免疫功能指标（IgA、IgG、IgM）对比（
±s）
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| 组别 | 例数 | 治疗时间 | IgA | IgG | IgM |
|---|
| 对照组 | 101 | 治疗前 | 4.00±0.27 | 9.95±1.54 | 12.25±1.11 |
| | 治疗后 | 6.31±0.21* | 15.07±1.00* | 18.63±1.02* |
| 观察组 | 100 | 治疗前 | 3.98±0.30 | 9.98±1.60 | 12.30±1.05 |
| | 治疗后 | 10.49±0.25* | #2.85±1.13*# | 23.26±1.00*# |
), ArticleFig(id=1322926160761463060, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 治疗前 | 治疗后 |
|---|
| 对照组 | 101 | 68.34±4.23 | 79.84±3.23* |
| 观察组 | 100 | 69.41±4.18 | 89.74±5.23*# |
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两组甲状腺术后咳嗽患者KPS评分比较（
±s）
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| 组别 | 例数 | 治疗前 | 治疗后 |
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| 对照组 | 101 | 68.34±4.23 | 79.84±3.23* |
| 观察组 | 100 | 69.41±4.18 | 89.74±5.23*# |
), ArticleFig(id=1322926160895680790, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 乏力 | 恶心 | 总不良反应 |
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| 对照组 | 101 | 1 | 1 | 2（1.98） |
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| χ2值 | | | | 0.328 4 |
| P值 | | | | 0.566 6 |
), ArticleFig(id=1322926160966983959, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322926152372854992, language=CN, label=表8, caption=
两组甲状腺术后咳嗽患者不良反应比较
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| 组别 | 例数 | 乏力 | 恶心 | 总不良反应 |
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| 观察组 | 100 | 1 | 0 | 1（1.00） |
| χ2值 | | | | 0.328 4 |
| P值 | | | | 0.566 6 |
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