Article(id=1322925932683600571, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322925862630339452, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.07.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339721126, onlineDateStr=2026-10-30, pubDate=1752076800000, pubDateStr=2025-07-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339721126, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339721126, creator=13701087609, updateTime=1793339721126, updator=13701087609, issue=Issue{id=1322925862630339452, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='7', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1752076800000', pubDateStr='2025-07-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339704424, creator='13701087609', updateTime=1793340532184, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929334587105328, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322925862630339452, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929334587105329, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322925862630339452, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=45, endPage=48, ext={EN=ArticleExt(id=1322925934411653823, articleId=1322925932683600571, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Clinical Observation of Shenqi Erzhi Prescription（参芪二至方）Combined with Tacrolimus in Treatment of IgA Nephropathy, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the clinical effect of Shenqi Erzhi Prescription（参芪二至方）combined with tacrolimus in the treatment of immunoglobulin A（IgA）nephropathy.
Methods In this study，144 patients with IgA nephropathy（admitted from April 2020 to June 2023）were divided into Western medicine group（72 cases，tacrolimus）and comibined traditional Chinese medicine group（72 cases，Shenqi Erzhi Prescription combined with tacrolimus）. Two cases fell off during the treatment. Three cases fell off in the Western medicine group，and the data of each group was observed，including the treatment effect，the changes of TCM syndrome scores（thirst and drinking，shortness of breath，fatigue，dysphoria in chestpalms-soles，spontaneous sweating，etc.），the levels of blood creatinine（SCr），blood urea nitrogen（BUN），24 h urinary protein quantitative changes，complement C3 and IgA，interleukin-6（IL-6）and interleukin-17（IL-17）and other indexes changes before and after treatment in each group and adverse reactions.
Results The total effective rate of the comibined traditional Chinese medicine group was significantly higher than that of Western medicine group（P<0.05）. Before treatment，TCM syndrome scores，renal function related indexes（SCr，BUN，24 h urinary protein quantitative），the levels of complement C3，IgA，IL-6 and IL-17 were not significant in two groups（P>0.05）. After treatment，TCM syndrome scores，renal function related indexes（SCr，BUN，24 h urinary protein quantitative），the levels of IgA，IL-6 and IL-17 were significantly decreased in two groups，and complement C3 was increased. And these results were all lower in the comibined traditional Chinese medicine group than those in the Western group，and the complement C3 index was higher than that in the Western group（P<0.05）. The rate of adverse reactions in the comibined traditional Chinese medicine group was lower than that in the Western medicine group（P<0.05）.
Conclusion Shenqi Erzhi Prescription combined with tacrolimus has a significant effect in the treatment of IgA nephropathy，with improved clinical symptoms，renal function and immune function，less adverse reactions，and it is a safe and reliable treatment.
, authors=Xuelei ZHU, Wanqiu TONG, Heting YAO, authorsList=Xuelei ZHU, Wanqiu TONG, Heting YAO, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322925936429114058, articleId=1322925932683600571, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=参芪二至方结合他克莫司治疗IgA肾病临床疗效观察, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 探讨参芪二至方结合他克莫司治疗免疫球蛋白A（IgA）肾病临床疗效。
方法 研究纳入144例IgA肾病患者（2020年4月—2023年6月收治）进行分组，采取随机数字表法将患者分为采取他克莫司治疗的西医组（72例）以及采取参芪二至方结合他克莫司治疗的结合中药组（72例），治疗过程中结合中药组脱落2例，西医组脱落3例，观察各组患者数据：治疗效果、治疗前与治疗后各组患者中医证候积分（口渴喜饮、气短、神疲乏力、五心烦热、自汗等）变化、血肌酐（SCr）、尿素氮（BUN）、24 h尿蛋白定量等肾功能指标变化、补体C3及IgA指标变化、白细胞介素-6（IL-6）及白细胞介素-17（IL-17）等指标变化、治疗不良反应。
结果 结合中药组患者治疗总有效率显著高于西医组患者（P<0.05）；治疗前各组患者中医证候积分（口渴喜饮、气短、神疲乏力、五心烦热、自汗等）、肾功能相关指标（SCr、BUN、24 h尿蛋白定量）、补体C3及IgA、IL-6以及IL-17水平比较，均P>0.05；治疗后各组患者中医证候积分、肾功能相关指标（SCr、BUN、24 h尿蛋白定量）、IgA、IL-6以及IL-17水平等指标均显著下降，补体C3指标上升，而结合中药组患者治疗后中医证候积分、肾功能相关指标（SCr、BUN、24 h尿蛋白定量）、IgA、IL-6以及IL-17水平等指标均低于西医组，补体C3指标高于西医组（P<0.05）；结合中药组患者治疗不良反应率低于西医组（P<0.05）。
结论 参芪二至方结合他克莫司治疗IgA肾病效果显著，患者临床病症、肾功能以及免疫功能均改善，不良反应较少，治疗安全可靠。
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朱学雷（1981-），男，安徽怀宁人，副主任医师，学士，研究方向：肾病相关。
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浙江中医药大学学报，
2023，
47（9）：1026-1031，1058., articleTitle=基于数据挖掘探讨王永钧教授治疗IgA肾病的用药规律, refAbstract=null), Reference(id=1322925948504515334, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, doi=null, pmid=null, pmcid=null, year=2023, volume=16, issue=6, pageStart=1152, pageEnd=1155, url=null, language=null, rfNumber=［8］, rfOrder=7, authorNames=孙超凡, 王暴魁, journalName=环球中医药, refType=null, unstructuredReference=孙超凡，王暴魁. 基于黏膜免疫探讨玄府—络脉与IgA肾病的发生发展关系［J］.
环球中医药，
2023，
16（6）：1152-1155., articleTitle=基于黏膜免疫探讨玄府—络脉与IgA肾病的发生发展关系, refAbstract=null), Reference(id=1322925948630344455, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, doi=null, pmid=null, pmcid=null, year=2023, volume=51, issue=1, pageStart=62, pageEnd=66, url=null, language=null, rfNumber=［9］, rfOrder=8, authorNames=张沛, 何旭, 高春林, journalName=中医药学报, refType=null, unstructuredReference=张沛，何旭，高春林，
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中医药学报，
2023，
51（1）：62-66., articleTitle=加味升降散对儿童IgA肾病伴急性肾损伤的免疫调控作用及临床疗效观察, refAbstract=null), Reference(id=1322925948726813448, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, doi=null, pmid=null, pmcid=null, year=2023, volume=30, issue=3, pageStart=156, pageEnd=159, url=null, language=null, rfNumber=［10］, rfOrder=9, authorNames=郑娱, 王琛, journalName=中国中医药信息杂志, refType=null, unstructuredReference=郑娱，王琛. 基于玄府理论辨治IgA肾病［J］.
中国中医药信息杂志，
2023，
30（3）：156-159., articleTitle=基于玄府理论辨治IgA肾病, refAbstract=null), Reference(id=1322925948793922313, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, doi=null, pmid=null, pmcid=null, year=2022, volume=29, issue=2, pageStart=72, pageEnd=76, url=null, language=null, rfNumber=［11］, rfOrder=10, authorNames=高航, 赵亚洲, 刘春莹, journalName=现代中医临床, refType=null, unstructuredReference=高航，赵亚洲，刘春莹. 中西医基于肠肾轴对IgA肾病的认识和治疗［J］.
现代中医临床，
2022，
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中国中西医结合杂志，
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山东中医杂志，
2023，
42（6）：627-632., articleTitle=王耀献从藏象学说论治IgA肾病经验, refAbstract=null), Reference(id=1322925949070746381, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, doi=null, pmid=null, pmcid=null, year=2023, volume=36, issue=6, pageStart=61, pageEnd=66, url=null, language=null, rfNumber=［15］, rfOrder=14, authorNames=庞欣欣, 王学艺, 朱清, journalName=西部中医药, refType=null, unstructuredReference=庞欣欣，王学艺，朱清，
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西部中医药，
2023，
36（6）：61-66., articleTitle=中药栀子治疗IgA肾病的网络药理学研究, refAbstract=null), Reference(id=1322925949142049550, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, doi=null, pmid=null, pmcid=null, year=2023, volume=30, issue=10, pageStart=12, pageEnd=16, url=null, language=null, rfNumber=［16］, rfOrder=15, authorNames=郑娱, 王琛, journalName=中国中医药信息杂志, refType=null, unstructuredReference=郑娱，王琛. 基于肠肾轴理论探讨甘草泻心汤治疗IgA肾病作用机制［J］.
中国中医药信息杂志，
2023，
30（10）：12-16., articleTitle=基于肠肾轴理论探讨甘草泻心汤治疗IgA肾病作用机制, refAbstract=null), Reference(id=1322925949213352719, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, doi=null, pmid=null, pmcid=null, year=2022, volume=39, issue=1, pageStart=4, pageEnd=7, url=null, language=null, rfNumber=［17］, rfOrder=16, authorNames=张逸馨, 王耀光, journalName=天津中医药, refType=null, unstructuredReference=张逸馨，王耀光. 黄文政教授运用疏利少阳三焦法治疗IgA肾病经验管窥［J］.
天津中医药，
2022，
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中国医药导报，
2022，
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中国中西医结合肾病杂志，
2022，
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中国医药导报，
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中国中西医结合肾病杂志，
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中国中西医结合肾病杂志，
2023，
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现代中西医结合杂志，
2023，
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中华中医药学刊，
2019，
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中华中医药学刊，
2021，
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现代药物与临床，
2023，
38（11）：2819-2824., articleTitle=百令胶囊联合羟氯喹治疗原发性IgA肾病的临床研究, refAbstract=null), Reference(id=1322925950253540121, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, doi=null, pmid=null, pmcid=null, year=2022, volume=23, issue=3, pageStart=272, pageEnd=273, url=null, language=null, rfNumber=［27］, rfOrder=26, authorNames=陈明, 田锋, 吴宸广, journalName=中国中西医结合肾病杂志, refType=null, unstructuredReference=陈明，田锋，吴宸广，
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中国中西医结合肾病杂志，
2022，
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长春中医药大学学报，
2022，
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中药新药与临床药理，
2022，
33（3）：398-404., articleTitle=肾病Ⅱ号方治疗IgA肾病单纯性血尿的有效性和安全性研究, refAbstract=null), Reference(id=1322925952052896540, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, doi=null, pmid=null, pmcid=null, year=2023, volume=29, issue=12, pageStart=135, pageEnd=141, url=null, language=null, rfNumber=［30］, rfOrder=29, authorNames=张倩, 杨凤文, 石蒙, journalName=中国实验方剂学杂志, refType=null, unstructuredReference=张倩，杨凤文，石蒙，
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中国实验方剂学杂志，
2023，
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2023，
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| 组别 | 例数 | 痊愈 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 西医组 | 69 | 19 | 21 | 20 | 9 | 60（86.96） |
| 结合中药组 | 70 | 36 | 22 | 10 | 2 | 68（97.14） |
| χ2值 | | | | | | 4.947 6 |
| P值 | | | | | | 0.026 1 |
), ArticleFig(id=1322925945342010097, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, language=CN, label=表1, caption=
两组IgA肾病患者治疗效果比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 痊愈 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 西医组 | 69 | 19 | 21 | 20 | 9 | 60（86.96） |
| 结合中药组 | 70 | 36 | 22 | 10 | 2 | 68（97.14） |
| χ2值 | | | | | | 4.947 6 |
| P值 | | | | | | 0.026 1 |
), ArticleFig(id=1322925945421701874, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | 口渴喜饮 | 气短 | 神疲乏力 | 五心烦热 | 自汗 |
|---|
| 西医组 | 69 | 治疗前 | 2.03±0.25 | 2.00±0.22 | 1.86±0.29 | 1.83±0.32 | 1.79±0.25* |
| | 治疗后 | 0.58±0.10* | 0.56±0.08* | 0.55±0.07* | 0.53±0.04* | 0.51±0.06 |
| 结合中药组 | 70 | 治疗前 | 2.00±0.19 | 1.96±0.27 | 1.90±0.32 | 1.85±0.29 | 1.80±0.19 |
| | 治疗后 | 0.16±0.09*# | 0.15±0.06*# | 0.14±0.04*# | 0.15±0.03*# | 0.14±0.04*# |
), ArticleFig(id=1322925945539142387, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, language=CN, label=表2, caption=
两组IgA肾病患者治疗前、治疗后的中医证候积分变化比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | 口渴喜饮 | 气短 | 神疲乏力 | 五心烦热 | 自汗 |
|---|
| 西医组 | 69 | 治疗前 | 2.03±0.25 | 2.00±0.22 | 1.86±0.29 | 1.83±0.32 | 1.79±0.25* |
| | 治疗后 | 0.58±0.10* | 0.56±0.08* | 0.55±0.07* | 0.53±0.04* | 0.51±0.06 |
| 结合中药组 | 70 | 治疗前 | 2.00±0.19 | 1.96±0.27 | 1.90±0.32 | 1.85±0.29 | 1.80±0.19 |
| | 治疗后 | 0.16±0.09*# | 0.15±0.06*# | 0.14±0.04*# | 0.15±0.03*# | 0.14±0.04*# |
), ArticleFig(id=1322925945639805684, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | SCr/（mmol/L） | BUN/（mmol/L） | 24 h尿蛋白定量/（g） |
|---|
| 西医组 | 69 | 治疗前 | 88.32±5.12 | 5.67±0.55 | 3.73±0.47 |
| | 治疗后 | 84.26±6.12* | 4.25±0.36* | 1.48±0.40* |
| 结合中药组 | 70 | 治疗前 | 88.28±5.09 | 5.59±0.59 | 3.71±0.45 |
| | 治疗后 | 80.23±4.82*# | 3.79±0.28*# | 0.81±0.26*# |
), ArticleFig(id=1322925945732080373, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, language=CN, label=表3, caption=
两组IgA肾病患者治疗前后肾功能相关指标（SCr、BUN、24 h尿蛋白定量）变化比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | SCr/（mmol/L） | BUN/（mmol/L） | 24 h尿蛋白定量/（g） |
|---|
| 西医组 | 69 | 治疗前 | 88.32±5.12 | 5.67±0.55 | 3.73±0.47 |
| | 治疗后 | 84.26±6.12* | 4.25±0.36* | 1.48±0.40* |
| 结合中药组 | 70 | 治疗前 | 88.28±5.09 | 5.59±0.59 | 3.71±0.45 |
| | 治疗后 | 80.23±4.82*# | 3.79±0.28*# | 0.81±0.26*# |
), ArticleFig(id=1322925945799189238, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | 补体C3 | IgA |
|---|
| 西医组 | 69 | 治疗前 | 0.45±0.09 | 5.39±0.74 |
| | 治疗后 | 0.85±0.07* | 3.31±0.37* |
| 结合中药组 | 70 | 治疗前 | 0.41±0.10 | 5.40±0.69 |
| | 治疗后 | 1.13±0.05*# | 2.32±0.31*# |
), ArticleFig(id=1322925947455939319, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, language=CN, label=表4, caption=
两组IgA肾病患者治疗前后补体C3及IgA变化比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | 补体C3 | IgA |
|---|
| 西医组 | 69 | 治疗前 | 0.45±0.09 | 5.39±0.74 |
| | 治疗后 | 0.85±0.07* | 3.31±0.37* |
| 结合中药组 | 70 | 治疗前 | 0.41±0.10 | 5.40±0.69 |
| | 治疗后 | 1.13±0.05*# | 2.32±0.31*# |
), ArticleFig(id=1322925947531436792, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | IL-6/（pg/mL） | IL-17/（ng/L） |
|---|
| 西医组 | 69 | 治疗前 | 26.93±6.23 | 64.29±7.33 |
| | 治疗后 | 14.29±5.23* | 43.26±5.12* |
| 结合中药组 | 70 | 治疗前 | 27.01±6.19 | 64.36±6.99 |
| | 治疗后 | 11.27±4.92*# | 37.49±4.85*# |
), ArticleFig(id=1322925947598545657, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, language=CN, label=表5, caption=
两组IgA肾病患者治疗前后IL-6、IL-17水平变化比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | IL-6/（pg/mL） | IL-17/（ng/L） |
|---|
| 西医组 | 69 | 治疗前 | 26.93±6.23 | 64.29±7.33 |
| | 治疗后 | 14.29±5.23* | 43.26±5.12* |
| 结合中药组 | 70 | 治疗前 | 27.01±6.19 | 64.36±6.99 |
| | 治疗后 | 11.27±4.92*# | 37.49±4.85*# |
), ArticleFig(id=1322925947669848826, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 血压异常 | 皮疹 | 胃肠功能不适 | 总不良反应 |
|---|
| 西医组 | 69 | 1 | 1 | 6 | 8（11.59） |
| 结合中药组 | 70 | 0 | 0 | 2 | 2（2.86） |
| χ2值 | | | | | 3.972 9 |
| P值 | | | | | 0.046 2 |
), ArticleFig(id=1322925947741151995, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322925932683600571, language=CN, label=表6, caption=
两组IgA肾病患者不良反应比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 血压异常 | 皮疹 | 胃肠功能不适 | 总不良反应 |
|---|
| 西医组 | 69 | 1 | 1 | 6 | 8（11.59） |
| 结合中药组 | 70 | 0 | 0 | 2 | 2（2.86） |
| χ2值 | | | | | 3.972 9 |
| P值 | | | | | 0.046 2 |
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