Article(id=1322923826039889992, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.06.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339218864, onlineDateStr=2026-10-30, pubDate=1749484800000, pubDateStr=2025-06-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339218864, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339218864, creator=13701087609, updateTime=1793339218864, updator=13701087609, issue=Issue{id=1322923782029062261, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='6', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1749484800000', pubDateStr='2025-06-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339208371, creator='13701087609', updateTime=1793340556755, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929437859258468, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929437859258469, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923782029062261, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=61, endPage=65, ext={EN=ArticleExt(id=1322923826266382409, articleId=1322923826039889992, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effect of Jiangzu Decoction（降阻汤）Combined with Antihypertensive Treatment on Plasma ADMA，sFlt-1/PIGF and Maternal and Infant Prognosis in Mild to Moderate Pregnancy Hypertension, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the effects of Jiangzi Decoction（降阻汤）combined with antihypertensive therapy on plasma asymmetric dimethylarginine in mild to moderate pregnancy hypertension（ADMA），soluble vascular endothelial growth factor receptor-1（sFlt-1）/placental growth factor（PIGF）and maternal and infant outcomes.
Methods A total of 108 patients with mild to moderate gestational hypertension treated in the hospital from September 2020 to October 2023 were included as research objects.They were divided into two groups by random number table method.Fifty-four patients in the control group received routine antihypertensive treatment，and the other 54 patients in the observation group received Jiangzi Decoction combined with antihypertensive treatment.The efficacy，blood pressure，symptom scores，plasma levels of ADMA and sFlt/PIGF，ultrasound hemodynamic index of placenta and pregnancy outcome were compared between the two groups.
Results The total effective rate of the observation group was 96.30%，much higher than that of the control group（79.63%）（P<0.05）.After treatment，dizziness，waist and knee weakness，five upset and heat symptom scores and blood pressure levels in the observation group were lower than those in the control group（P<0.05）.After treatment，the values of pulsatility index（PI），resistance index（RI）and S/D in the observation group were lower than those in the control group.The levels of ADMA，sFlt-1 and sFlt-1/PIGF in the observation group were lower than those in the control group，and PIGF levels were higher than those in the control group（P<0.05）.The incidence of adverse pregnancy outcome was3.70% in the observation group，which was much lower than that（14.81%）in the con-trol group（P<0.05）.
Conclusion Jiangzu Decoction can nourish Yin and suppress Yang，invigorate Qi and tonify kidney，tranquilize the mind and stabilize the fetus.And when combined with antihypertensive therapy for mild to moderate pregnancy hypertension，it can effectively control blood pressure，alleviate symptoms，regulate microcirculation，improve placental hemodynamic indexes，and reduce the levels of ADMA and sFlt/PIGF，improve pregnancy outcomes and ensure the safety of mothers and infants.
, authors=Yun RONG
1, Zhexia HU
1, Xiao CHEN
1, Jingwen JIANG
1, Yuntao BU
2, Xueling ZHANG
1, authorsList=Yun RONG, Zhexia HU, Xiao CHEN, Jingwen JIANG, Yuntao BU, Xueling ZHANG, authorCompany=null, correspAuthors=Xueling ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322923827654697044, articleId=1322923826039889992, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=降阻汤联合降压治疗对轻中度妊娠期高血压血浆ADMA、sFlt-1/PIGF及母婴预后的影响, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 分析降阻汤联合降压治疗对轻中度妊娠期高血压病血浆非对称性二甲基精氨酸（ADMA）、可溶性血管内皮生长因子受体1（sFlt-1）/胎盘生长因子（PIGF）及母婴预后的影响。
方法 纳入2020年9月—2023年10月石家庄市第四医院就诊的108例轻中度妊娠期高血压病患者为研究对象，随机数字表法将其分为两组，54例对照组采用常规降压治疗，54例观察组采用降阻汤联合降压治疗，对比两组疗效差异、血压水平、症状评分、血浆ADMA、sFlt/PIGF水平、胎盘超声血流动力学指标及妊娠结局。
结果 观察组治疗总有效率为96.30%，远高于对照组的79.63%（P<0.05）；治疗后观察组头晕目眩、腰膝酸软、五心烦热症状评分及血压水平均低于对照组（P<0.05）；治疗后观察组Pl、RI、S/D水平均低于对照组，观察组ADMA、sFlt-1、sFlt-1/PIGF水平低于对照组，PIGF水平高于对照组（P<0.05）；观察组治疗不良妊娠结局发生率为3.70%，远低于对照组的14.81%（P<0.05）。
结论 降阻汤滋阴潜阳、益气补肾、安神固胎，联合降压治疗轻中度妊娠期高血压病能有效控制其血压水平，缓解患者症状，调节微循环，改善胎盘血流动力学指标，降低ADMA、sFlt-1、sFlt-1/PIGF水平，改善妊娠结局，保障母婴安全。
, authors=荣赟
1, 胡哲霞
1, 陈晓
1, 蒋静雯
1, 卜云涛
2, 张雪玲
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荣赟（1982-），女，河北石家庄人，主治医师，硕士，研究方向：妊娠期高血压病。
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2.中国人民解放军联勤保障部队第980医院，河北 石家庄 050000)])], figs=[ArticleFig(id=1322923832587198600, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923826039889992, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 观察组 | 54 | 41（75.93） | 11（20.37） | 2（3.70） | 52（96.30） |
| 对照组 | 54 | 29（53.70） | 14（25.93） | 11（20.37） | 43（79.63） |
| χ2值 | - | - | - | - | 11.048 2 |
| P值 | - | - | - | - | 0.024 8 |
), ArticleFig(id=1322923832666890377, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923826039889992, language=CN, label=表1, caption=
两组妊娠高血压病患者治疗效果比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 显效 | 有效 | 无效 | 总有效 |
|---|
| 观察组 | 54 | 41（75.93） | 11（20.37） | 2（3.70） | 52（96.30） |
| 对照组 | 54 | 29（53.70） | 14（25.93） | 11（20.37） | 43（79.63） |
| χ2值 | - | - | - | - | 11.048 2 |
| P值 | - | - | - | - | 0.024 8 |
), ArticleFig(id=1322923834323640458, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923826039889992, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 收缩压 | t值 | P值 | 舒张压 | t值 | P值 |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 54 | 149.72±9.62 | 121.52±9.62 | 15.251 7 | 0.000 0 | 99.62±8.62 | 81.62±5.12 | 17.468 2 | 0.000 0 |
| 对照组 | 54 | 149.76±10.13 | 135.59±8.63 | 11.014 8 | 0.000 0 | 98.45±7.62 | 89.92±6.52 | 9.146 2 | 0.000 0 |
| t值 | - | 0.322 1 | 8.152 3 | - | - | 0.327 3 | 7.132 6 | - | |
| P值 | - | 0.748 5 | 0.000 0 | - | - | 0.489 2 | 0.000 0 | - | - |
), ArticleFig(id=1322923834415915148, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923826039889992, language=CN, label=表2, caption=
两组妊娠高血压病患者血压水平比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 收缩压 | t值 | P值 | 舒张压 | t值 | P值 |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 54 | 149.72±9.62 | 121.52±9.62 | 15.251 7 | 0.000 0 | 99.62±8.62 | 81.62±5.12 | 17.468 2 | 0.000 0 |
| 对照组 | 54 | 149.76±10.13 | 135.59±8.63 | 11.014 8 | 0.000 0 | 98.45±7.62 | 89.92±6.52 | 9.146 2 | 0.000 0 |
| t值 | - | 0.322 1 | 8.152 3 | - | - | 0.327 3 | 7.132 6 | - | |
| P值 | - | 0.748 5 | 0.000 0 | - | - | 0.489 2 | 0.000 0 | - | - |
), ArticleFig(id=1322923834495606925, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923826039889992, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | 头晕目眩 | 腰膝酸软 | 五心烦热 |
|---|
| 观察组 | 54 | 治疗前 | 4.02±0.15 | 3.98±0.18 | 3.13±0.16 |
| | 治疗后 | 0.92±0.11 | 0.79±0.14 | 0.59±0.19 |
| | t值 | 13.525 4 | 24.876 7 | 19.482 2 |
| | P值 | 0.000 0 | 0.000 0 | 0.000 0 |
| 对照组 | 54 | 治疗前 | 4.03±0.16 | 3.97±0.14 | 3.14±0.17 |
| | 治疗后 | 1.59±0.12 | 1.75±0.14 | 1.42±0.17 |
| | t值 | 9.155 7 | 11.486 2 | 13.426 7 |
| | P值 | 0.000 0 | 0.000 0 | 0.000 0 |
| 两组治疗前t值 | 0.295 2 | 0.178 2 | 0.378 5 |
| 两组治疗前P值 | 0.826 7 | 0.276 3 | 0.249 6 |
| 两组治疗后t值 | 9.529 7 | 13.582 6 | 12.826 4 |
| 两组治疗后P值 | 0.000 0 | 0.000 0 | 0.000 0 |
), ArticleFig(id=1322923834566910095, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923826039889992, language=CN, label=表3, caption=
两组妊娠高血压病患者症状积分比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | 头晕目眩 | 腰膝酸软 | 五心烦热 |
|---|
| 观察组 | 54 | 治疗前 | 4.02±0.15 | 3.98±0.18 | 3.13±0.16 |
| | 治疗后 | 0.92±0.11 | 0.79±0.14 | 0.59±0.19 |
| | t值 | 13.525 4 | 24.876 7 | 19.482 2 |
| | P值 | 0.000 0 | 0.000 0 | 0.000 0 |
| 对照组 | 54 | 治疗前 | 4.03±0.16 | 3.97±0.14 | 3.14±0.17 |
| | 治疗后 | 1.59±0.12 | 1.75±0.14 | 1.42±0.17 |
| | t值 | 9.155 7 | 11.486 2 | 13.426 7 |
| | P值 | 0.000 0 | 0.000 0 | 0.000 0 |
| 两组治疗前t值 | 0.295 2 | 0.178 2 | 0.378 5 |
| 两组治疗前P值 | 0.826 7 | 0.276 3 | 0.249 6 |
| 两组治疗后t值 | 9.529 7 | 13.582 6 | 12.826 4 |
| 两组治疗后P值 | 0.000 0 | 0.000 0 | 0.000 0 |
), ArticleFig(id=1322923834654990480, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923826039889992, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | PI | RI | S/D |
|---|
| 观察组 | 54 | 治疗前 | 1.35±0.24 | 0.72±0.12 | 3.05±0.40 |
| | 治疗后 | 0.91±0.13 | 0.53±0.09 | 2.35±0.18 |
| | t值 | 11.846 0 | 9.308 1 | 11.727 1 |
| | P值 | 0.000 0 | 0.000 0 | 0.000 0 |
| 对照组 | 54 | 治疗前 | 1.33±0.31 | 0.74±0.10 | 3.02±0.38 |
| | 治疗后 | 1.06±0.18 | 0.60±0.07 | 2.78±0.22 |
| | t值 | 5.534 9 | 8.428 1 | 4.016 6 |
| | P值 | 0.000 0 | 0.000 0 | 0.000 1 |
| 两组治疗前t值 | 0.374 9 | 0.940 9 | 0.399 6 |
| 两组治疗前P值 | 0.708 5 | 0.348 9 | 0.690 3 |
| 两组治疗后t值 | 4.964 4 | 4.511 5 | 11.116 3 |
| 两组治疗后P值 | 0.000 0 | 0.000 0 | 0.000 0 |
), ArticleFig(id=1322923834730487953, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923826039889992, language=CN, label=表4, caption=
两组妊娠高血压病患者胎盘血流动力学指标比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | PI | RI | S/D |
|---|
| 观察组 | 54 | 治疗前 | 1.35±0.24 | 0.72±0.12 | 3.05±0.40 |
| | 治疗后 | 0.91±0.13 | 0.53±0.09 | 2.35±0.18 |
| | t值 | 11.846 0 | 9.308 1 | 11.727 1 |
| | P值 | 0.000 0 | 0.000 0 | 0.000 0 |
| 对照组 | 54 | 治疗前 | 1.33±0.31 | 0.74±0.10 | 3.02±0.38 |
| | 治疗后 | 1.06±0.18 | 0.60±0.07 | 2.78±0.22 |
| | t值 | 5.534 9 | 8.428 1 | 4.016 6 |
| | P值 | 0.000 0 | 0.000 0 | 0.000 1 |
| 两组治疗前t值 | 0.374 9 | 0.940 9 | 0.399 6 |
| 两组治疗前P值 | 0.708 5 | 0.348 9 | 0.690 3 |
| 两组治疗后t值 | 4.964 4 | 4.511 5 | 11.116 3 |
| 两组治疗后P值 | 0.000 0 | 0.000 0 | 0.000 0 |
), ArticleFig(id=1322923834801791122, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923826039889992, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | 血浆ADMA/（μmol/L） | sFlt-1/（ng/mL） | PIGF/（ng/mL） | sFlt-1/PIGF |
|---|
| 观察组 | 54 | 治疗前 | 2.31±0.56 | 1 419.52±328.45 | 37.21±5.21 | 39.82±5.72 |
| | 治疗后 | 0.75±0.11 | 1 129.85±298.82 | 54.52±8.48 | 20.82±4.62 |
| | t值 | 18.492 2 | 15.268 8 | 16.782 2 | 22.148 7 |
| | P值 | 0.000 0 | 0.000 0 | 0.000 0 | 0.000 0 |
| 对照组 | 54 | 治疗前 | 2.34±0.51 | 1 422.42±329.78 | 37.42±4.24 | 38.42±4.22 |
| | 治疗后 | 1.79±0.25 | 1 324.52±348.87 | 41.02±7.82 | 29.72±7.44 |
| | t值 | 8.564 3 | 12.496 2 | 9.789 5 | 11.592 5 |
| | P值 | 0.000 0 | 0.000 0 | 0.000 0 | 0.000 0 |
| 两组治疗前t值 | 0.287 9 | 0.186 2 | 0.247 9 | 0.249 5 |
| 两组治疗前P值 | 0.794 7 | 0.249 7 | 0.397 5 | 0.478 2 |
| 两组治疗后t值 | 19.782 2 | 5.975 8 | 15.482 6 | 23.749 5 |
| 两组治疗后P值 | 0.000 0 | 0.000 0 | 0.000 0 | 0.000 0 |
), ArticleFig(id=1322923834885677203, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923826039889992, language=CN, label=表5, caption=
两组妊娠高血压病患者血浆ADMA、sFlt-1及PIGF水平比较（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 时间 | 血浆ADMA/（μmol/L） | sFlt-1/（ng/mL） | PIGF/（ng/mL） | sFlt-1/PIGF |
|---|
| 观察组 | 54 | 治疗前 | 2.31±0.56 | 1 419.52±328.45 | 37.21±5.21 | 39.82±5.72 |
| | 治疗后 | 0.75±0.11 | 1 129.85±298.82 | 54.52±8.48 | 20.82±4.62 |
| | t值 | 18.492 2 | 15.268 8 | 16.782 2 | 22.148 7 |
| | P值 | 0.000 0 | 0.000 0 | 0.000 0 | 0.000 0 |
| 对照组 | 54 | 治疗前 | 2.34±0.51 | 1 422.42±329.78 | 37.42±4.24 | 38.42±4.22 |
| | 治疗后 | 1.79±0.25 | 1 324.52±348.87 | 41.02±7.82 | 29.72±7.44 |
| | t值 | 8.564 3 | 12.496 2 | 9.789 5 | 11.592 5 |
| | P值 | 0.000 0 | 0.000 0 | 0.000 0 | 0.000 0 |
| 两组治疗前t值 | 0.287 9 | 0.186 2 | 0.247 9 | 0.249 5 |
| 两组治疗前P值 | 0.794 7 | 0.249 7 | 0.397 5 | 0.478 2 |
| 两组治疗后t值 | 19.782 2 | 5.975 8 | 15.482 6 | 23.749 5 |
| 两组治疗后P值 | 0.000 0 | 0.000 0 | 0.000 0 | 0.000 0 |
), ArticleFig(id=1322923834973757588, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923826039889992, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 分组 | 例数 | 早产 | 自然流产 | 胎盘早剥 | 产后出血 | 总发生 |
|---|
| 观察组 | 54 | 1（1.85） | 0（0） | 0（0） | 1（1.85） | 2（3.70） |
| 对照组 | 54 | 3（5.56） | 2（3.70） | 1（1.85） | 2（3.70） | 8（14.81） |
| χ2值 | - | - | - | - | - | 3.967 3 |
| P值 | - | - | - | - | - | 0.046 4 |
), ArticleFig(id=1322923835040866454, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923826039889992, language=CN, label=表6, caption=
两组妊娠高血压病患者妊娠结局比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 分组 | 例数 | 早产 | 自然流产 | 胎盘早剥 | 产后出血 | 总发生 |
|---|
| 观察组 | 54 | 1（1.85） | 0（0） | 0（0） | 1（1.85） | 2（3.70） |
| 对照组 | 54 | 3（5.56） | 2（3.70） | 1（1.85） | 2（3.70） | 8（14.81） |
| χ2值 | - | - | - | - | - | 3.967 3 |
| P值 | - | - | - | - | - | 0.046 4 |
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