Article(id=1322923710931411189, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923490592043032, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.05.032, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793339191419, onlineDateStr=2026-10-30, pubDate=1746806400000, pubDateStr=2025-05-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793339191419, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793339191419, creator=13701087609, updateTime=1793339191419, updator=13701087609, issue=Issue{id=1322923490592043032, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='5', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1746806400000', pubDateStr='2025-05-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793339138887, creator='13701087609', updateTime=1793340572227, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929502539612595, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923490592043032, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929502539612596, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322923490592043032, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=172, endPage=182, ext={EN=ArticleExt(id=1322923711128543478, articleId=1322923710931411189, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Research Progress on Chemical Composition and Pharmacological Effects of Lingzhi（Ganoderma）and Prediction Analysis of Quality Marker, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=

Lingzhi（Ganoderma）is the dried fruiting body of Zhenjun Chizhi［Ganoderma lucidum（Leyss.ex Fr.）Karst.］or Zizhi（Ganoderma sinense Zhao，Xu et Zhang）of the polyporeaceae fungus，which is a traditional Chinese precious medicinal material and is listed as the top grade. At present，the types of compounds isolated from Lingzhi（Ganoderma）mainly include polysaccharides，triterpenoids，proteins，sterols，vitamins and trace elements，etc.，which have a wide range of biological activities and pharmacological effects，such as regulating immunity，anti-cancer，anti-oxidation，anti-aging，anti-inflammatory，etc. In this paper，the chemical composition and pharmacological effects of Lingzhi（Ganoderma）were reviewed，and the quality markers（QMarker）were predicted from multiple aspects，and the polysaccharides of Lingzhi（Ganoderma），total triterpenoids of Lingzhi（Ganoderma），Ganoderic acid A，Ganoderic acid B，Ganoderic acid C2，Ganoderic acid E，Ganoderma lucidum kettotriol，Ganoderma lucidum terpene diol，ergosterol，ergosterol peroxide，Ganoderma lucidum uridine，uracil，protein，amino acids，trace elements，vitamin components and heavy metal elements（Pb，Cd，As，Hg）and other components may become Q-Markers of Lingzhi（Ganoderma），which provides a basis for the quality control and evaluation of Lingzhi（Ganoderma）.

, authors=Jing RAN¹, Zunbao YAO², Hui XU¹, Wei ZHANG¹, Xueyuan BAI¹, authorsList=Jing RAN, Zunbao YAO, Hui XU, Wei ZHANG, Xueyuan BAI, authorCompany=null, correspAuthors=Wei ZHANG, Xueyuan BAI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322923712336503039, articleId=1322923710931411189, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=灵芝化学成分、药理作用及质量标志物预测分析, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=

灵芝为多孔菌科真菌赤芝Ganoderma lucidum（Leyss.ex Fr.）Karst.或紫芝Ganoderma sinense Zhao，Xu et Zhang的干燥子实体，是中国传统名贵药材，被列为上品。目前从灵芝中分离得到的化合物种类主要有多糖类、三萜类、蛋白质、甾醇、维生素和微量元素等，这些成分都具有广泛的生物活性和药理作用，如调节免疫、抗癌、抗氧化、抗衰老、抗炎等。对灵芝的化学成分及其药理作用进行综述，并从多个方面进行其质量标志物（Quality marker，Q-Marker）的预测，初步确定灵芝多糖、灵芝总三萜、灵芝酸A、灵芝酸B、灵芝酸C₂、灵芝酸E、灵芝酮三醇、灵芝萜烯二醇、麦角甾醇、过氧化麦角甾醇、灵芝尿苷、尿嘧啶、蛋白质、氨基酸、微量元素、维生素成分及重金属元素铅、镉、砷、汞等成分可能成为灵芝的质量标志物，为灵芝的质量控制与评价提供依据。

, authors=冉靖¹, 姚遵宝², 徐慧¹, 张巍¹, 白雪媛¹, authorsList=冉靖, 姚遵宝, 徐慧, 张巍, 白雪媛, authorCompany=null, correspAuthors=张巍, 白雪媛, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=PhP+TL5yoL7kyLh+SpkUsQ==, magXml=DOicazvTWAI8zHCgAqpUyw==, pdfUrl=null, pdf=GlXvIivXxTNH0BvgAP5v6w==, pdfFileSize=2596186, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=AmawF45d3YwYGF9MoZqejQ==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=0BoCRk4hANeGDz6BzEa64A==, mapNumber=null, fund=null)}, authors=[Author(id=1322923712789487879, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923710931411189, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322923712869179657, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923710931411189, authorId=1322923712789487879, language=EN, stringName=Jing RAN, firstName=Jing, middleName=null, lastName=RAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Changchun University of Chinese Medicine，Changchun 130021，Jilin，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322923712944677130, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923710931411189, authorId=1322923712789487879, language=CN, stringName=冉靖, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.长春中医药大学，吉林 长春 130021, bio={"content":"

冉靖（1999-），女，四川万源人，硕士，研究方向：中药分析与检验方法。

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冉靖（1999-），女，四川万源人，硕士，研究方向：中药分析与检验方法。

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编号	化合物名称	分子式	文献
1	ganoderiol D	C30H48O5	［16］
2	ganoderiol F	C30H46O3	［16］
3	ganoderiol E	C30H48O4	［16］
4	ganoderic acid A	C30H44O7	［16-17］
5	ganoderic acid B	C30H44O7	［16，18］
6	ganoderic acid D2	C30H42O8	［16］
7	lucidumol A	C30H48O4	［16，19］
8	lucidadiol	C30H48O3	［16］
9	ganoderiol A	C30H50O4	［16］
10	lucidumol B	C30H50O3	［16］
11	ganodermanondiol	C30H48O3	［16］
12	lucidenic acid A	C27H38O6	［16，18］
13	ganolucidic acid A	C30H44O6	［16-17］
14	ganoderic acid J	C30H42O7	［16-17］
15	methyl lucidenate A	C28H40O6	［16］
16	ganoderic acid E	C30H40O7	［16-17］
17	ganoderenic acid D	C30H40O7	［16-17］
18	ganoderic acid F	C32H42O9	［16］
19	ganodermanontriol	C30H48O4	［16］
20	ganoderiol B	C30H46O4	［16］
21	ganoderic acid C	C30H48O7	［16］
22	lucidenic acid F	C27H36O6	［17］
23	12-hydroxyganoderic acid D	C30H42O8	［17］
24	ganoderic acid C2	C30H46O7	［17-18］
25	ganoderic acid G	C30H44O8	［17-18］
26	ganoderic acid H	C32H44O9	［17-18］
27	ganoderic acid C6	C30H42O8	［17-18］
28	lucidenic acid N	C27H40O6	［17-18］
29	ganoderenic acid B	C30H42O7	［17-18］
30	ganolucidic acid B	C30H46O6	［17］
31	ganoderic acid K	C32H46O9	［17］
32	ganoderic acid D	C30H42O8	［17］
33	ganolucidic acid D	C30H44O6	［17］
34	ganoderenic acid K	C32H44O9	［18］
35	ganoderic acid GS-1	C30H42O6	［20］
36	ganoderic acid GS-2	C30H44O6	［20］
37	ganoderic acid GS-3	C32H46O8	［20］
38	ganoderic acid Df23S-hydroxy-3，7，11，15-tetrao-	C30H44O7	［21］
39	xo-lanost-8，24E-diene-26-oic acid	C30H40O7	［22］
40	ganoderone A	C30H46O3	［23］

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灵芝中的三萜类化合物

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编号	化合物名称	分子式	文献
1	ganoderiol D	C30H48O5	［16］
2	ganoderiol F	C30H46O3	［16］
3	ganoderiol E	C30H48O4	［16］
4	ganoderic acid A	C30H44O7	［16-17］
5	ganoderic acid B	C30H44O7	［16，18］
6	ganoderic acid D2	C30H42O8	［16］
7	lucidumol A	C30H48O4	［16，19］
8	lucidadiol	C30H48O3	［16］
9	ganoderiol A	C30H50O4	［16］
10	lucidumol B	C30H50O3	［16］
11	ganodermanondiol	C30H48O3	［16］
12	lucidenic acid A	C27H38O6	［16，18］
13	ganolucidic acid A	C30H44O6	［16-17］
14	ganoderic acid J	C30H42O7	［16-17］
15	methyl lucidenate A	C28H40O6	［16］
16	ganoderic acid E	C30H40O7	［16-17］
17	ganoderenic acid D	C30H40O7	［16-17］
18	ganoderic acid F	C32H42O9	［16］
19	ganodermanontriol	C30H48O4	［16］
20	ganoderiol B	C30H46O4	［16］
21	ganoderic acid C	C30H48O7	［16］
22	lucidenic acid F	C27H36O6	［17］
23	12-hydroxyganoderic acid D	C30H42O8	［17］
24	ganoderic acid C2	C30H46O7	［17-18］
25	ganoderic acid G	C30H44O8	［17-18］
26	ganoderic acid H	C32H44O9	［17-18］
27	ganoderic acid C6	C30H42O8	［17-18］
28	lucidenic acid N	C27H40O6	［17-18］
29	ganoderenic acid B	C30H42O7	［17-18］
30	ganolucidic acid B	C30H46O6	［17］
31	ganoderic acid K	C32H46O9	［17］
32	ganoderic acid D	C30H42O8	［17］
33	ganolucidic acid D	C30H44O6	［17］
34	ganoderenic acid K	C32H44O9	［18］
35	ganoderic acid GS-1	C30H42O6	［20］
36	ganoderic acid GS-2	C30H44O6	［20］
37	ganoderic acid GS-3	C32H46O8	［20］
38	ganoderic acid Df23S-hydroxy-3，7，11，15-tetrao-	C30H44O7	［21］
39	xo-lanost-8，24E-diene-26-oic acid	C30H40O7	［22］
40	ganoderone A	C30H46O3	［23］

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序号	化合物名称	分子式	文献
1	ganoderol A	C30H46O2	［29］
2	ganoderol B	C30H48O2	［29］
3	ganoderal A	C30H44O2	［29］
4	ergosterol	C28H44O	［30］
5	cerevisterol	C28H46O3	［30］
6	ergosta-7，22-dien-3β-ol	C28H46O	［30-31］
7	ergosta-4，6，8（14），22-tetraen-3-one	C28H40O	［31］
8	ergosta-7，22-dien-3-one	C28H44O	［32］
9	3，5-dihydroxyergosta-7，22-dien-6-one	C28H44O3	［32］
10	beta-Sitosterol	C29H50O	［32］
11	carrot glycoside	C35H60O6	［32］
12	5，8-epidioxiergosta-6，22-dien-3β-ol	C28H44O3	［32-33］
13	6，9-epidioxyergosta-7，22-dien-3β-ol	C28H44O2	［32］
14	ergoster-7，22-diene-3β-palmitate	C44H76O2	［32］
15	ergoster-7，22-diene-3 one	C28H44O	［32］
16	ganodermaside A	C28H40O2	［34-35］
17	ganodermaside B	C28H40O2	［34］
18	ganodermaside C	C28H40O2	［34，36］
19	ganodermaside D	C28H38O3	［34，36］
20	ergosta-7-en-3β-ol	C28H48O	［31］
21	24-methyl-cholester-5，22-diene-3βalcohol	C28H46O	［37］

), ArticleFig(id=1322923719760421172, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923710931411189, language=CN, label=表2, caption=

灵芝中的甾醇类化合物

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序号	化合物名称	分子式	文献
1	ganoderol A	C30H46O2	［29］
2	ganoderol B	C30H48O2	［29］
3	ganoderal A	C30H44O2	［29］
4	ergosterol	C28H44O	［30］
5	cerevisterol	C28H46O3	［30］
6	ergosta-7，22-dien-3β-ol	C28H46O	［30-31］
7	ergosta-4，6，8（14），22-tetraen-3-one	C28H40O	［31］
8	ergosta-7，22-dien-3-one	C28H44O	［32］
9	3，5-dihydroxyergosta-7，22-dien-6-one	C28H44O3	［32］
10	beta-Sitosterol	C29H50O	［32］
11	carrot glycoside	C35H60O6	［32］
12	5，8-epidioxiergosta-6，22-dien-3β-ol	C28H44O3	［32-33］
13	6，9-epidioxyergosta-7，22-dien-3β-ol	C28H44O2	［32］
14	ergoster-7，22-diene-3β-palmitate	C44H76O2	［32］
15	ergoster-7，22-diene-3 one	C28H44O	［32］
16	ganodermaside A	C28H40O2	［34-35］
17	ganodermaside B	C28H40O2	［34］
18	ganodermaside C	C28H40O2	［34，36］
19	ganodermaside D	C28H38O3	［34，36］
20	ergosta-7-en-3β-ol	C28H48O	［31］
21	24-methyl-cholester-5，22-diene-3βalcohol	C28H46O	［37］

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编号	必需氨基酸	编号	非必需氨基酸
1	苏氨酸Thr	1	天门冬氨基酸Asp
2	苯丙氨酸Phe	2	丝氨酸Ser
3	缬氨酸Val	3	谷氨酸Glu
4	甲硫氨酸Met	4	脯氨酸Pro
5	异亮氨酸Ile	5	甘氨酸Gly
6	亮氨酸Leu	6	络氨酸Tyr
7	赖氨酸Lys	7	组氨酸His
		8	精氨酸Arg
		9	丙氨酸Aal
		10	胱氨酸Cys

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灵芝中的氨基酸类化合物

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编号	必需氨基酸	编号	非必需氨基酸
1	苏氨酸Thr	1	天门冬氨基酸Asp
2	苯丙氨酸Phe	2	丝氨酸Ser
3	缬氨酸Val	3	谷氨酸Glu
4	甲硫氨酸Met	4	脯氨酸Pro
5	异亮氨酸Ile	5	甘氨酸Gly
6	亮氨酸Leu	6	络氨酸Tyr
7	赖氨酸Lys	7	组氨酸His
		8	精氨酸Arg
		9	丙氨酸Aal
		10	胱氨酸Cys

), ArticleFig(id=1322923719970136375, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923710931411189, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=

编号	化合物名称	文献
1	维生素C	［46］
2	维生素B12	［46］
3	维生素B1	［46］
4	维生素B2	［46］
5	维生素B6	［46］
6	维生素A	［47］
7	维生素D2	［47］
8	维生素D3	［47］
9	维生素E	［47］
10	胡萝卜素	［48］

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灵芝中的维生素类

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编号	化合物名称	文献
1	维生素C	［46］
2	维生素B12	［46］
3	维生素B1	［46］
4	维生素B2	［46］
5	维生素B6	［46］
6	维生素A	［47］
7	维生素D2	［47］
8	维生素D3	［47］
9	维生素E	［47］
10	胡萝卜素	［48］

), ArticleFig(id=1322923720116937017, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923710931411189, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=

编号	微量元素名称	文献
1	钙	［49］
2	镁	［49］
3	锌	［49］
4	锰	［49］
5	铁	［49］
6	钴	［49］
7	铜	［49］
8	钾	［49］
9	锗	［49］
10	钒	［49］
11	钠	［49］
12	镍	［49］
13	铬	［49］
14	磷	［49］
15	硒	［49］
16	硫	［50］
17	硅	［50］

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灵芝中的微量元素

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编号	微量元素名称	文献
1	钙	［49］
2	镁	［49］
3	锌	［49］
4	锰	［49］
5	铁	［49］
6	钴	［49］
7	铜	［49］
8	钾	［49］
9	锗	［49］
10	钒	［49］
11	钠	［49］
12	镍	［49］
13	铬	［49］
14	磷	［49］
15	硒	［49］
16	硫	［50］
17	硅	［50］

), ArticleFig(id=1322923720272126267, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322923710931411189, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=

编号	化合物中文名称	化合物英文名称	分子式	文献
1	胞嘧啶	Cytosine	C4H5N3O	［51］
2	尿嘧啶	Uracil	C4H4N2O2	［51］
3	胞苷	Cytidine	C9H13N3O5	［51］
4	次黄嘌呤	6-Hydroxypurine	C5H4N4O	［51］
5	黄嘌呤	2，6-Dihydroxypurine	C5H4N4O2	［51］
6	尿苷	Uridine	C9H12N2O6	［51］
7	胸腺嘧啶	Thymine	C5H6N2O2	［51］
8	肌苷	Thymine	C10H12N4O5	［51］
9	腺嘌呤	Adenine	C5H5N5	［51］
10	鸟苷	Guanosine	C10H13N5O5	［51］
11	2＇-脱氧鸟苷	2＇-Deoxyguanosine	C10H13N5O4	［51］
12	胸苷	Thymidine	C10H14N2O5	［51］
13	腺苷	Adenosine	C10H13N5O4	［51］
14	2＇-脱氧腺苷	2＇-Deoxyadenosine	C10H13N5O3	［51］
15	3＇-脱氧腺苷	Cordycepin	C10H13N5O3	［51］

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灵芝中的核苷类成分

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编号	化合物中文名称	化合物英文名称	分子式	文献
1	胞嘧啶	Cytosine	C4H5N3O	［51］
2	尿嘧啶	Uracil	C4H4N2O2	［51］
3	胞苷	Cytidine	C9H13N3O5	［51］
4	次黄嘌呤	6-Hydroxypurine	C5H4N4O	［51］
5	黄嘌呤	2，6-Dihydroxypurine	C5H4N4O2	［51］
6	尿苷	Uridine	C9H12N2O6	［51］
7	胸腺嘧啶	Thymine	C5H6N2O2	［51］
8	肌苷	Thymine	C10H12N4O5	［51］
9	腺嘌呤	Adenine	C5H5N5	［51］
10	鸟苷	Guanosine	C10H13N5O5	［51］
11	2＇-脱氧鸟苷	2＇-Deoxyguanosine	C10H13N5O4	［51］
12	胸苷	Thymidine	C10H14N2O5	［51］
13	腺苷	Adenosine	C10H13N5O4	［51］
14	2＇-脱氧腺苷	2＇-Deoxyadenosine	C10H13N5O3	［51］
15	3＇-脱氧腺苷	Cordycepin	C10H13N5O3	［51］

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