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Article(id=1322922739480277857, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322922680609014711, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.02.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793338959808, onlineDateStr=2026-10-30, pubDate=1739116800000, pubDateStr=2025-02-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793338959808, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793338959808, creator=13701087609, updateTime=1793338959808, updator=13701087609, issue=Issue{id=1322922680609014711, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='2', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1739116800000', pubDateStr='2025-02-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793338945772, creator='13701087609', updateTime=1793340618065, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929694785536732, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322922680609014711, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929694785536733, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322922680609014711, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=45, endPage=48, ext={EN=ArticleExt(id=1322922739702575970, articleId=1322922739480277857, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Observation on the Effect and Prognosis of Fuzheng Qufeng Decoction（扶正祛风汤）Combined with Dumai Moxibustion in Treating Chronic Urticaria with Yang Deficiency, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective

To investigate the effect of Fuzheng Qufeng Decoction（扶正祛风汤）combined with Du meridian moxibustion on chronic urticaria with yang deficiency.

Methods

72 cases of chronic urticaria with yang deficiency admitted to the hospital from January 2020 to January 2022 were selected as the research objects. According to the random number table，they were divided into the observation group（36 cases were treated with Fuzheng Qufeng Decoction and Du meridian Moxibustion）and the control group（36 cases were treated with loratadine）. The clinical efficacy，symptom score，urticaria activity score（urticaria activity score，UAS），dermatosis quality of life scale（dermatosis quality of life scale，DQLS）and immune function（T lymphocyte subsets：CD4+，CD8+）of the two groups were observed.

Results

After treatment，the total effective rate in the observation group was 94.44%（34/36），which was higher than that in the control group（75.00%，27/36，P<0.05）. Before treatment，there was no significant difference between the two groups in the number of wheals，maximum diameter，frequency of wheals，duration or other symptom scores（P>0.05）. After treatment，the number，maximum diameter，frequency and duration of wheals in the observation group were lower than those in the control group. The data difference was statistically significant（P<0.05）. Before treatment，there was no significant difference in the scores of pruritus degree or number of wheals between the two groups（P>0.05）. After treatment，the scores of pruritus degree and number of wheals in the observation group were lower than those in the control group. The data difference was statistically significant（P<0.05）. Two weeks，one month，and two months after treatment，the scores of skin disease quality of life of the patients in the observation group were lower than those of the patients in the control group. The data difference was statistically significant（P<0.05）. Before treatment，there was no significant difference in CD4+，CD8+or CD4+/CD8+values between the two groups（P>0.05）. After treatment，the CD4+and CD4+/CD8+values in the observation group were higher than those in the control group. The CD8+value of patients in the observation group was lower than that of patients in the control group（P<0.05）.

Conclusion

The self prepared Fuzheng Qufeng Decoction combined with Du meridian moxibustion can improve the clinical efficacy of chronic urticaria patients with yang deficiency，improve the clinical symptoms，reduce the activity score of urticaria，improve the quality of life of skin diseases，and improve the immune function，which is worthy of clinical promotion.

, authors=Qianying YU, Qing LEI, Min XIAO, Jing GUO, authorsList=Qianying YU, Qing LEI, Min XIAO, Jing GUO, authorCompany=null, correspAuthors=Jing GUO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322922742923801458, articleId=1322922739480277857, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=扶正祛风汤联合督脉灸治疗阳虚质慢性荨麻疹疗效观察, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的

探讨扶正祛风汤联合督脉灸治疗阳虚质慢性荨麻疹（chronic urticaria，CU）的效果。

方法

选取2020年1月—2022年1月收治的72例阳虚质慢性荨麻疹作为研究对象，按照随机数字表法分为观察组36例（扶正祛风汤联合督脉灸治疗）和对照组36例（给予氯雷他定治疗）。观察两组的临床疗效、症状积分、荨麻疹活动性评分（urticaria activity score，UAS）、皮肤病生活质量量表（dermatosis quality of life scale，DQLS）以及免疫功能（T淋巴细胞亚群：CD4+、CD8+）。

结果

治疗后，观察组总有效率为94.44%（34/36），高于对照组患者的75.00%（27/36）（P<0.05）。治疗前，两组患者的风团数目、最大直径、风团发作频率、持续时间等症状积分比较，差异无统计学意义（P>0.05）；治疗后，观察组患者的风团数目、最大直径、风团发作频率、持续时间等症状积分均低于对照组，差异有统计学意义（P<0.05）。治疗前，两组患者的瘙痒程度、风团数目评分比较，差异无统计学意义（P>0.05）；治疗后，观察组患者的瘙痒程度、风团数目评分低于对照组，差异有统计学意义（P<0.05）。治疗后2周、1个月、2个月，观察组患者的皮肤病生活质量评分均低于对照组，差异有统计学意义（P<0.05）。治疗前，两组患者的CD4+、CD8+值以及CD4+/CD8+值比较，差异无统计学意义（P>0.05）。治疗后，观察组患者的CD4+与CD4+/CD8+值高于对照组（P<0.05）；观察组患者的CD8+值低于对照组（P<0.05）。

结论

扶正祛风汤联合督脉灸能够提高阳虚质慢性荨麻疹患者的临床疗效，改善临床症状，降低荨麻疹活动性评分，提高皮肤病生活质量，改善免疫功能，值得临床推广。

, authors=余倩颖, 雷晴, 肖敏, 郭静, authorsList=余倩颖, 雷晴, 肖敏, 郭静, authorCompany=null, correspAuthors=郭静, authorNote=

余倩颖（1984-），女，四川成都人，副主任医师，硕士，研究方向：中医药防治皮肤病。

, correspAuthorsNote=
郭静（1978-），女，四川遂宁人，主任医师，博士，研究方向：中医药防治皮肤病。E-mail：。
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余倩颖（1984-），女，四川成都人，副主任医师，硕士，研究方向：中医药防治皮肤病。

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余倩颖（1984-），女，四川成都人，副主任医师，硕士，研究方向：中医药防治皮肤病。

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金蝉止痒胶囊联合依匹斯汀治疗慢性荨麻疹临床疗效及对血清炎性因子的影响［J］. 湖北中医药大学学报，2021，23（3）：81-83., articleTitle=金蝉止痒胶囊联合依匹斯汀治疗慢性荨麻疹临床疗效及对血清炎性因子的影响, refAbstract=null), Reference(id=1322922749630493623, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, doi=null, pmid=null, pmcid=null, year=2021, volume=23, issue=2, pageStart=197, pageEnd=198，201, url=null, language=null, rfNumber=［26］, rfOrder=25, authorNames=王仲洵, 甘霖, 史欣怡, journalName=浙江临床医学, refType=null, unstructuredReference=王仲洵，甘霖，史欣怡，等. 调神针法治疗慢性荨麻疹34例［J］. 浙江临床医学，2021，23（2）：197-198，201., articleTitle=调神针法治疗慢性荨麻疹34例, refAbstract=null), Reference(id=1322922749697602488, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, doi=null, pmid=null, pmcid=null, year=2021, volume=41, issue=7, pageStart=841, pageEnd=845, url=null, language=null, rfNumber=［27］, rfOrder=26, authorNames=全天华, 刘喜迎, 陈越, journalName=吉林中医药, refType=null, unstructuredReference=全天华，刘喜迎，陈越，等. 平胃消疹汤联合盐酸奥洛他定片治疗慢性荨麻疹胃肠湿热证临床疗效观察［J］. 吉林中医药，2021，41（7）：841-845., articleTitle=平胃消疹汤联合盐酸奥洛他定片治疗慢性荨麻疹胃肠湿热证临床疗效观察, refAbstract=null), Reference(id=1322922749756322745, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, doi=null, pmid=null, pmcid=null, year=2021, volume=27, issue=6, pageStart=887, pageEnd=890, url=null, language=null, rfNumber=［28］, rfOrder=27, authorNames=甘露, 张忠奎, 刘太华, journalName=国际医药卫生导报, refType=null, unstructuredReference=甘露，张忠奎，刘太华，等. 依巴斯汀、复方甘草酸苷联合吡嘧司特钾治疗慢性荨麻疹的临床疗效观察［J］. 国际医药卫生导报，2021，27（6）：887-890., articleTitle=依巴斯汀、复方甘草酸苷联合吡嘧司特钾治疗慢性荨麻疹的临床疗效观察, refAbstract=null), Reference(id=1322922749819237306, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, doi=null, pmid=null, pmcid=null, year=2017, volume=49, issue=3, pageStart=95, pageEnd=98, url=null, language=null, rfNumber=［29］, rfOrder=28, authorNames=朱康明, journalName=新中医, refType=null, unstructuredReference=朱康明. 中药药浴联合左西替利嗪治疗慢性荨麻疹临床观察［J］. 新中医，2017，49（3）：95-98., articleTitle=中药药浴联合左西替利嗪治疗慢性荨麻疹临床观察, refAbstract=null), Reference(id=1322922751484375995, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, doi=null, pmid=null, pmcid=null, year=2022, volume=43, issue=6, pageStart=611, pageEnd=615, url=null, language=null, rfNumber=［30］, rfOrder=29, authorNames=关吉利, 陆江涛, 孔珍珍, journalName=海军医学杂志, refType=null, unstructuredReference=关吉利，陆江涛，孔珍珍，等. 麻黄连翘赤小豆汤加减治疗慢性荨麻疹对其活动性评分及生活质量的影响［J］. 海军医学杂志，2022，43（6）：611-615., articleTitle=麻黄连翘赤小豆汤加减治疗慢性荨麻疹对其活动性评分及生活质量的影响, refAbstract=null)], funds=[Fund(id=1322922747319432092, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, awardId=2022-256, language=CN, fundingSource=国家中医药管理局青年岐黄学者项目(2022-256), fundOrder=null, country=null), Fund(id=1322922747394929565, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, awardId=QJJJ2021001, language=CN, fundingSource=“杏林学者”学科人才科研提升计划项目(QJJJ2021001), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322922743146099571, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, xref=null, ext=[AuthorCompanyExt(id=1322922743158682484, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, companyId=1322922743146099571, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China), AuthorCompanyExt(id=1322922743171265397, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, companyId=1322922743146099571, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=成都中医药大学附属医院，四川 成都 610072)])], figs=[ArticleFig(id=1322922744714769296, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
组别例数性别/（例）年龄/（岁，±s）病程/（月，±s）瘙痒发作频次/（次/d）
男女1~23~5>5
观察组36181828.23±3.1227.12±3.17111213
对照组36201628.43±3.2427.45±4.12101115
t/χ2值0.2230.2670.3810.234
P值0.63907900.7040.890
), ArticleFig(id=1322922744786072465, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, language=CN, label=表1, caption=

两组慢性荨麻疹患者基础资料对比

, figureFileSmall=null, figureFileBig=null, tableContent=
组别例数性别/（例）年龄/（岁，±s）病程/（月，±s）瘙痒发作频次/（次/d）
男女1~23~5>5
观察组36181828.23±3.1227.12±3.17111213
对照组36201628.43±3.2427.45±4.12101115
t/χ2值0.2230.2670.3810.234
P值0.63907900.7040.890
), ArticleFig(id=1322922744882541458, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
组别例数显效有效无效总有效
观察组3628（77.78）6（16.67）2（5.56）34（94.44）
对照组3622（61.11）5（13.89）9（25.00）27（75.00）
χ2值2.3560.1075.2585.258
P值0.1240.7430.0220.022
), ArticleFig(id=1322922744991593363, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, language=CN, label=表2, caption=

两组慢性荨麻疹患者临床疗效对比

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组别例数显效有效无效总有效
观察组3628（77.78）6（16.67）2（5.56）34（94.44）
对照组3622（61.11）5（13.89）9（25.00）27（75.00）
χ2值2.3560.1075.2585.258
P值0.1240.7430.0220.022
), ArticleFig(id=1322922745067090836, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
组别例数风团数目风团最大直径风团发作频率持续时间
治疗前治疗后治疗前治疗后治疗前治疗后治疗前治疗后
观察组363.07±0.211.02±0.56*3.48±0.431.47±0.48*3.62±0.341.34±0.47*2.84±0.241.26±0.22*
对照组363.04±0.232.34±0.48*3.44±0.532.23±0.43*3.67±0.222.33±0.87*2.82±0.232.51±0.49*
t值0.5788.1100.3527.0560.7416.0070.36113.963
P值0.5650.0000.7260.0000.4610.0000.7190.000
), ArticleFig(id=1322922745155171221, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, language=CN, label=表3, caption=

两组慢性荨麻疹患者症状积分对比（±s）

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组别例数风团数目风团最大直径风团发作频率持续时间
治疗前治疗后治疗前治疗后治疗前治疗后治疗前治疗后
观察组363.07±0.211.02±0.56*3.48±0.431.47±0.48*3.62±0.341.34±0.47*2.84±0.241.26±0.22*
对照组363.04±0.232.34±0.48*3.44±0.532.23±0.43*3.67±0.222.33±0.87*2.82±0.232.51±0.49*
t值0.5788.1100.3527.0560.7416.0070.36113.963
P值0.5650.0000.7260.0000.4610.0000.7190.000
), ArticleFig(id=1322922745222280086, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
组别例数瘙痒程度风团数目
治疗前治疗后治疗前治疗后
观察组364.07±1.211.27±0.35*4.48±1.432.47±0.48*
对照组364.15±1.242.85±0.24*4.44±1.533.23±0.43*
t值0.27722.3380.1158.887
P值0.7830.0000.9090.000
), ArticleFig(id=1322922745306166167, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, language=CN, label=表4, caption=

两组慢性荨麻疹患者UAS评分对比（±s）

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组别例数瘙痒程度风团数目
治疗前治疗后治疗前治疗后
观察组364.07±1.211.27±0.35*4.48±1.432.47±0.48*
对照组364.15±1.242.85±0.24*4.44±1.533.23±0.43*
t值0.27722.3380.1158.887
P值0.7830.0000.9090.000
), ArticleFig(id=1322922745385857944, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
组别例数治疗前治疗后2周治疗后1个月治疗后2个月
观察组3624.82±1.3512.23±1.43*9.12±1.47*4.23±1.43*
对照组3624.84±1.2417.47±1.12*15.93±1.87*9.47±1.12*
t值0.06317.30917.17817.309
P值0.9500.0000.0000.000
), ArticleFig(id=1322922747042608025, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, language=CN, label=表5, caption=

两组慢性荨麻疹患者DQLS评分对比（±s）

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组别例数治疗前治疗后2周治疗后1个月治疗后2个月
观察组3624.82±1.3512.23±1.43*9.12±1.47*4.23±1.43*
对照组3624.84±1.2417.47±1.12*15.93±1.87*9.47±1.12*
t值0.06317.30917.17817.309
P值0.9500.0000.0000.000
), ArticleFig(id=1322922747130688410, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
组别例数CD4+/（%）CD8+/（%）CD4+/CD8+
治疗前治疗后治疗前治疗后治疗前治疗后
观察组3627.63±4.2645.41±7.29*26.39±5.4719.36±3.18*1.47±0.282.12±0.24*
对照组3627.71±4.9336.67±5.19*26.42±5.3622.57±4.21*1.41±0.341.61±0.19*
t值0.0866.8370.0274.2590.9549.050
P值0.9320.0000.9780.0000.3430.000
), ArticleFig(id=1322922747227157403, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322922739480277857, language=CN, label=表6, caption=

两组慢性荨麻疹患者CD4+、CD8+值以及CD4+/CD8+值比较（±s）

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组别例数CD4+/（%）CD8+/（%）CD4+/CD8+
治疗前治疗后治疗前治疗后治疗前治疗后
观察组3627.63±4.2645.41±7.29*26.39±5.4719.36±3.18*1.47±0.282.12±0.24*
对照组3627.71±4.9336.67±5.19*26.42±5.3622.57±4.21*1.41±0.341.61±0.19*
t值0.0866.8370.0274.2590.9549.050
P值0.9320.0000.9780.0000.3430.000
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扶正祛风汤联合督脉灸治疗阳虚质慢性荨麻疹疗效观察
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余倩颖 , 雷晴 , 肖敏 , 郭静
中华中医药学刊 | 国家项目点击 2025,43(2): 45-48
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中华中医药学刊 |国家项目点击 2025 , 43 (2) : 45 -48
扶正祛风汤联合督脉灸治疗阳虚质慢性荨麻疹疗效观察
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余倩颖, 雷晴, 肖敏, 郭静
作者信息
  • 成都中医药大学附属医院，四川 成都 610072
通讯作者:
郭静（1978-），女，四川遂宁人，主任医师，博士，研究方向：中医药防治皮肤病。E-mail：。
作者简介:

余倩颖（1984-），女，四川成都人，副主任医师，硕士，研究方向：中医药防治皮肤病。

Observation on the Effect and Prognosis of Fuzheng Qufeng Decoction（扶正祛风汤）Combined with Dumai Moxibustion in Treating Chronic Urticaria with Yang Deficiency
Qianying YU, Qing LEI, Min XIAO, Jing GUO
Affiliations
  • Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China
出版时间: 2025-02-10 doi: 10.13193/j.issn.1673-7717.2025.02.010
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摘要
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目的

探讨扶正祛风汤联合督脉灸治疗阳虚质慢性荨麻疹（chronic urticaria，CU）的效果。

方法

选取2020年1月—2022年1月收治的72例阳虚质慢性荨麻疹作为研究对象，按照随机数字表法分为观察组36例（扶正祛风汤联合督脉灸治疗）和对照组36例（给予氯雷他定治疗）。观察两组的临床疗效、症状积分、荨麻疹活动性评分（urticaria activity score，UAS）、皮肤病生活质量量表（dermatosis quality of life scale，DQLS）以及免疫功能（T淋巴细胞亚群：CD4+、CD8+）。

结果

治疗后，观察组总有效率为94.44%（34/36），高于对照组患者的75.00%（27/36）（P<0.05）。治疗前，两组患者的风团数目、最大直径、风团发作频率、持续时间等症状积分比较，差异无统计学意义（P>0.05）；治疗后，观察组患者的风团数目、最大直径、风团发作频率、持续时间等症状积分均低于对照组，差异有统计学意义（P<0.05）。治疗前，两组患者的瘙痒程度、风团数目评分比较，差异无统计学意义（P>0.05）；治疗后，观察组患者的瘙痒程度、风团数目评分低于对照组，差异有统计学意义（P<0.05）。治疗后2周、1个月、2个月，观察组患者的皮肤病生活质量评分均低于对照组，差异有统计学意义（P<0.05）。治疗前，两组患者的CD4+、CD8+值以及CD4+/CD8+值比较，差异无统计学意义（P>0.05）。治疗后，观察组患者的CD4+与CD4+/CD8+值高于对照组（P<0.05）；观察组患者的CD8+值低于对照组（P<0.05）。

结论

扶正祛风汤联合督脉灸能够提高阳虚质慢性荨麻疹患者的临床疗效，改善临床症状，降低荨麻疹活动性评分，提高皮肤病生活质量，改善免疫功能，值得临床推广。

扶正祛风汤  /  督脉灸治疗  /  阳虚质慢性荨麻疹
Objective

To investigate the effect of Fuzheng Qufeng Decoction（扶正祛风汤）combined with Du meridian moxibustion on chronic urticaria with yang deficiency.

Methods

72 cases of chronic urticaria with yang deficiency admitted to the hospital from January 2020 to January 2022 were selected as the research objects. According to the random number table，they were divided into the observation group（36 cases were treated with Fuzheng Qufeng Decoction and Du meridian Moxibustion）and the control group（36 cases were treated with loratadine）. The clinical efficacy，symptom score，urticaria activity score（urticaria activity score，UAS），dermatosis quality of life scale（dermatosis quality of life scale，DQLS）and immune function（T lymphocyte subsets：CD4+，CD8+）of the two groups were observed.

Results

After treatment，the total effective rate in the observation group was 94.44%（34/36），which was higher than that in the control group（75.00%，27/36，P<0.05）. Before treatment，there was no significant difference between the two groups in the number of wheals，maximum diameter，frequency of wheals，duration or other symptom scores（P>0.05）. After treatment，the number，maximum diameter，frequency and duration of wheals in the observation group were lower than those in the control group. The data difference was statistically significant（P<0.05）. Before treatment，there was no significant difference in the scores of pruritus degree or number of wheals between the two groups（P>0.05）. After treatment，the scores of pruritus degree and number of wheals in the observation group were lower than those in the control group. The data difference was statistically significant（P<0.05）. Two weeks，one month，and two months after treatment，the scores of skin disease quality of life of the patients in the observation group were lower than those of the patients in the control group. The data difference was statistically significant（P<0.05）. Before treatment，there was no significant difference in CD4+，CD8+or CD4+/CD8+values between the two groups（P>0.05）. After treatment，the CD4+and CD4+/CD8+values in the observation group were higher than those in the control group. The CD8+value of patients in the observation group was lower than that of patients in the control group（P<0.05）.

Conclusion

The self prepared Fuzheng Qufeng Decoction combined with Du meridian moxibustion can improve the clinical efficacy of chronic urticaria patients with yang deficiency，improve the clinical symptoms，reduce the activity score of urticaria，improve the quality of life of skin diseases，and improve the immune function，which is worthy of clinical promotion.

Fuzheng Qufeng Decoction（扶正祛风汤）  /  Du meridian Moxibustion  /  chronic urticaria with Yang deficiency
余倩颖, 雷晴, 肖敏, 郭静. 扶正祛风汤联合督脉灸治疗阳虚质慢性荨麻疹疗效观察. 中华中医药学刊, 2025 , 43 (2) : 45 -48 . DOI: 10.13193/j.issn.1673-7717.2025.02.010
Qianying YU, Qing LEI, Min XIAO, Jing GUO. Observation on the Effect and Prognosis of Fuzheng Qufeng Decoction（扶正祛风汤）Combined with Dumai Moxibustion in Treating Chronic Urticaria with Yang Deficiency[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (2) : 45 -48 . DOI: 10.13193/j.issn.1673-7717.2025.02.010
正文
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慢性荨麻疹（chronic urticaria，CU）是一种皮肤病，称风疹块[1]。其主要症状表现为皮肤出现风团状皮诊，伴有瘙痒，颜色主要为红色或者偏白色，也有可能出现水肿的症状，严重者甚至还会出现恶心、呕吐、胸闷等症状，严重影响了患者的生活质量[2]。其反复发作时间一般超过6周，每周至少两次[3]。该病病因复杂，可能与食物、患者年龄、季节变换、化妆品等有关。荨麻疹可以通过药物疗法进行治疗[4]。一般治疗荨麻疹的药物主要有抗组胺类药物，可以持久、高效地改善患者过敏症状，其中包括多塞平、H受体拮抗剂等。同时氯雷他定、氯苯那敏、西替利嗪、西咪替丁等，对于荨麻疹也有比较好的抑制作用，能缓解荨麻疹的症状[5-6]。荨麻疹也可以通过减少组胺释放从而减少荨麻疹的症状，如曲尼斯特、酮替酚、色甘酸钠等，也可以起到很好地抑制肥大细胞的作用，从而起到抑制荨麻疹的作用[7]。近年来，中医通过对CU辨证论治，取得良好疗效，表现出明显优势[8]。中医学称CU为“瘾疹”“风疹块”“瘾痧”，认为其病机为禀赋不耐、饮食不调、营卫气血等内因与风、湿等外邪侵袭相合所致，病位与大肠等脏腑有关。阳虚质慢性荨麻疹指素体阳气亏虚，阴寒内盛的体质状态[9]，治疗时以健脾益气和固表祛风为重点[10]。而扶正祛风汤以培土宁风作为治疗此病的基础原则，在健脾益气、实卫固表的基础上，达到抵御外邪侵袭的目的。督脉灸疗法是指在背部督脉段进行隔姜、隔药灸的一种灸疗方法，可以增强阳虚体质阳气[11-12]。而对于两者联合使用治疗的研究较少，因此本文主要探讨了扶正祛风汤联合督脉灸治疗阳虚质慢性荨麻疹的效果，现报道如下。
1　资料与方法
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1.1　一般资料
选取我院2020年1月—2022年1月收治的72例阳虚质慢性荨麻疹作为研究对象。纳入标准：①符合中医阳虚体质诊断标准[13]：主要包括畏寒肢冷，常与气虚症状共见。②符合西医诊断标准[14]。③年龄19～64岁，不限男女性别。④未参加其他临床试验研究者。排除标准：①已使用其他治疗慢性荨麻疹的中药、西药或中成药物，或正在使用治疗本病以外的疾病且影响试验方法观察的患者。②患有精神疾病者。③未按规定治疗，无法判定疗效者。两组患者基础资料对比差异无统计学意义（P>0.05），详见表1。
1.2　治疗方法
对照组：氯雷他定片（扬子江药业有限公司，生产批号：国药准字H20080134，规格：10 mg×12片）口服，每次10 mg，1次/d，连续服药8周为1个疗程。
观察组：予扶正祛风汤。组方：黄芪25 g，甘草5 g，红参15 g，鸡血藤15 g，当归15 g，白蒺藜15 g，白芍15g，桂枝15 g，熟地黄15 g，肉桂5 g，由药房统一煎煮包装，每剂400 mL，1剂/d，分早晚2次饭后温服，连续服药8周为1个疗程；并予督脉灸治疗，操作步骤如下：让病人俯卧位，在皮肤上先撒上一层药粉，其是根据病人的病情辨证之后开出来的药方，然后在药粉上再铺上桑皮纸，在桑皮纸上面铺上厚厚的姜蓉，约有5 cm，再在姜蓉上面放上艾桩点燃。1次/周，连续8周为1个疗程。
随访周期：两组均治疗1疗程后观察疗效，治疗结束及治疗结束后3、6个月均随访1次。
1.3　观察指标
（1）观察两组患者治疗后的临床疗效[15]。显效：阳虚质分数变化率<30%；有效：阳虚质分数变化率≥30%，<60%；无效：阳虚质分数变化率<30%。阳虚质转化分数变化率＝（治疗前分数-治疗后分数）/治疗前分数×100%。（2）观察两组患者治疗后的症状积分[16]。分别于治疗前与治疗后8周风团数目、风团最大直径、风团发作频率、持续时间等进行量化分级评分，按照严重程度无、轻、中、重分别记为1、2、3、4分。1分：无风团；2分：风团数目1～6个，风团最大直径0～1.5 cm，每日发作频率1次，风团持续时间<1 h；3分：风团数目7～12个，风团最大直径1.6～2.5 cm，每日发作频率2～3次，风团持续时间1～12 h；4分：风团数目>12个，风团最大直径>2.5 cm，每日发作频率>3次，风团持续时间>12 h，评分愈高，症状愈严重。（3）观察两组治疗前后的荨麻疹活动性评分（UAS）[17]。分别在治疗前与治疗后2个月评价患者荨麻疹活动度。（4）观察两组皮肤病生活质量量表（DQLS）[18]。分别在治疗前，治疗后2周，治疗后1个月，治疗后2个月分别测量患者生活质量。（5）观察两组免疫功能[19]。分别于治疗前与治疗后2个月采集患者晨起空腹条件下静脉血5 mL，离心处理（转速3000 r/min、离心10 min），留取血清，保存在-4℃冰箱内，待测结果。以流式细胞仪（安捷伦生物有限公司，3900型）按照酶联免疫吸附试验法及配套试剂盒测定T淋巴细胞亚群：CD4+、CD8+的值，并计算CD4+/CD8+的水平。
1.4　统计学分析
选用SPSS 23.0软件进行数据处理，计数资料表示为例（%），组间对比选用χ2检验，计量资料（）表示，应用t检验，P<0.05为差异具有统计学意义。
2　结果
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2.1　临床疗效比较
治疗后，观察组患者的总有效率为94.44%，高于对照组患者的75.00%（P<0.05），见表2。
2.2　症状积分比较
治疗后，观察组患者的风团数目、最大直径、风团发作频率、持续时间等症状积分均低于对照组患者（P<0.05），详见表3。
2.3　者UAS评分比较
治疗后，观察组患者的UAS评分低于对照组患者（P<0.05），见表4。
2.4　DQLS评分比较
治疗后2周，治疗后1个月，治疗后2个月，观察组的DQLS评分低于对照组（P<0.05），见表5。
2.5　免疫功能比较
治疗前，两组患者的CD4+、CD8+值以及CD4+/CD8+值比较，数据差异无明显统计学意义（P>0.05）。治疗后，观察组患者的CD4+与CD4+/CD8+值高于对照组患者，数据差异具备明显统计学意义（P<0.05）；观察组患者的CD8+值低于对照组患者，数据差异具备明显统计学意义（P<0.05），见表6。
3　讨论
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荨麻疹可分成急性和慢性两种，以急性的占大多数[20]。荨麻疹发病原因较多，较常见的是因个人体质特殊，体内免疫系统对外界的特定物质产生过敏反应；当吃到、吸进或接触到特定物质时，皮肤会因过敏反应使血管扩张、通透性增加而发生荨麻疹[21]。常规药物治疗可通过服用或者静脉注射糖皮质激素类药物，从而使荨麻疹的症状能较快地消退[22]。一般情况下，可以使用得宝松、泼尼松、地塞米松等药物进行治疗。还可以通过免疫抑制剂治疗，常用的免疫抑制剂主要有环孢素、免疫球蛋白等，但其不良反应较多[23]。本研究创新性地从“治未病”理论出发，采用扶正祛风汤联合督脉灸调理阳虚质慢性荨麻疹患者的体质，通过调节人体内环境阻断慢性荨麻疹进一步恶化，改善其症状[24]。同时又创新性地将扶正祛风汤针对阳虚质慢性荨麻疹患者进行改良，对于阳虚质慢性荨麻疹患者的畏寒肢冷症状，加入红参、肉桂等药品温中补虚，使其疗效更为明确。
本研究结果显示，治疗后观察组患者的症状积分均低于对照组患者，瘙痒程度、风团数目评分、皮肤病生活质量评分低于对照组患者，提示扶正祛风汤联合督脉灸能够提高阳虚质慢性荨麻疹患者的临床疗效，改善临床症状，降低荨麻疹活动性评分，提高皮肤病生活质量，这与叶峻宏等的研究结果一致[25]。考虑其原因为扶正祛风汤中的君药红参温中补虚；臣药黄芪益气固表；肉桂、桂枝温经通阳，鸡血藤行血补血，三药合用补而能行，推动阳气运行[26]。同时督脉灸属于中医艾灸的一种，主要是在背部督脉的循行部位进行艾灸的方法。按照中医理论，在背部正中走行的一条经络中医称为督脉，督脉灸具有扶正固本、温阳散寒的功效，主一身之阳气，为阳脉之海，即全身阳气充盛与否，与督脉的气血有着较为密切的联系，通过刺激督脉可以达到刺激人体阳气，促进人体阳气滋生的效果，这也是督脉灸的理论根源之一。通过艾灸的这种温热刺激，对督脉进行灸治，借助于督脉可以激发人体阳气的作用，达到扶正固本、温阳散寒的功效[27]。二者联合能够提高阳虚质慢性荨麻疹患者的临床疗效，能够在较大程度上改善其病症。
本研究结果显示，治疗后观察组患者的CD4+与CD4+/CD8+值高于对照组患者，CD8+值低于对照组患者，提示扶正祛风汤联合督脉灸能够提高阳虚质慢性荨麻疹患者的免疫功能，这与甘露等的研究结果一致[28]。考虑其原因为在未发病人体的真皮层中，淋巴细胞主要为T细胞。可分为辅助性T细胞（CD4+T）和抑制性T细胞（CD8+T），慢性荨麻疹患者真皮层中CD4+T和CD8+T比例约2∶1，比例失衡，主要表现为Th2免疫应答的增强，从而引起一系列超敏反应。而扶正祛风汤中的黄芪、甘草味甘性温，固表补中，养血镇痛；红参、鸡血藤味辛性热，疏风散寒，补火温中；当归、白蒺藜味辛性湿，散寒除湿，祛风通络；熟地辛温，散寒除湿、祛风通络；白芍、桂枝甘温，除风止搐；肉桂甘平，补脾和中，调和诸药。共奏温养气血，疏风解痉之效[29]。督脉灸简称为督灸，也称为长蛇灸，具有温阳散寒、通络止痛的作用，还具有一定的养生保健功效。督脉灸可以起到温阳通络、祛风除湿的作用。按照中医理论，督脉位于人体背部正中，在中医学理论中，督脉主一身之阳，是人体之气输送的主要通道，艾灸具有温阳通络、祛除寒邪、扶正固本的作用。督脉灸把二者特点相结合，可以振奋阳气、祛除病邪、防病保健，起到阳上加阳的作用[30]。
综上所述，扶正祛风汤联合督脉灸能够提高阳虚质慢性荨麻疹患者的临床疗效，改善临床症状，降低荨麻疹活动性评分，提高皮肤病生活质量，改善免疫功能，值得临床推广。
基金
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  • 国家中医药管理局青年岐黄学者项目(2022-256)
  • “杏林学者”学科人才科研提升计划项目(QJJJ2021001)
文献
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2025年第43卷第2期
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doi: 10.13193/j.issn.1673-7717.2025.02.010
  • 首发时间：2026-10-30
  • 出版时间：2025-02-10
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国家中医药管理局青年岐黄学者项目(2022-256)
“杏林学者”学科人才科研提升计划项目(QJJJ2021001)
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    成都中医药大学附属医院，四川 成都 610072

通讯作者:

郭静（1978-），女，四川遂宁人，主任医师，博士，研究方向：中医药防治皮肤病。E-mail：。
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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