Article(id=1322912302130922385, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322912162913596032, articleNumber=null, orderNo=null, doi=10.13193/j.issn.1673-7717.2025.01.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793336471350, onlineDateStr=2026-10-30, pubDate=1736438400000, pubDateStr=2025-01-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793336471350, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793336471350, creator=13701087609, updateTime=1793336471350, updator=13701087609, issue=Issue{id=1322912162913596032, tenantId=1146029695717560320, journalId=1255847919539208197, year='2025', volume='43', issue='1', pageStart='1', pageEnd='258', issueExtLink='null', onlineDate='null', pubDate='1736438400000', pubDateStr='2025-01-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793336438157, creator='13701087609', updateTime=1793340633627, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322929760048906989, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322912162913596032, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322929760048906990, tenantId=1146029695717560320, journalId=1255847919539208197, issueId=1322912162913596032, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=60, endPage=63, ext={EN=ArticleExt(id=1322912302411940754, articleId=1322912302130922385, tenantId=1146029695717560320, journalId=1255847919539208197, language=EN, title=Effects of Modified Zhibai Dihuang Pill（知柏地黄丸）Combined with Acupoint Catgut Embedding on Sex Hormone and Plasma Kisspeptin Levels in Girls with Idiopathic Central Precocious Puberty, columnId=1256183361521967297, journalTitle=Chinese Archives of Traditional Chinese Medicine, columnName=Target on National Project, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the effects of Modified Zhibai Dihuang Pill（知柏地黄丸）combined with acupoint catgutembedding on sex hormones and plasma Kisspeptin levels in girls with idiopathic central precocious puberty.
Methods Seventy-two girls with idiopathic central precocious puberty who received treatment in the hospital from June 2021 to December 2022 were selected as subjects of this study，and were randomly divided into observation group and control group according to random number table method，with 36 cases in each group. The observation group was treated with Modified Zhibai Dihuang Pill combined with acupoint catgut embedding. The control group was treated with lepraline acetate 3.75mg by subcutaneous injection. Growth and development indexes，secondary sex characteristics，sex hormone levels and plasma Kisspept in levels were compared between the two groups.
Results There were no significant differences in heightand weightbet ween two groups before and after treatment（P>0.05）. The bone age index between two groups before treatment had no significance（P>0.05）. The bone age indexes in the two groups after treatment were significantly lower than those before treatment，and the index in the observation group was significantly lower than that in the control group（P<0.05）. There were no significantdifferences in the diameter of milk nucleus，uterine volume，ovarian volume ormaximum follicle diameter between the two groups before treatment（P>0.05）. After treatment，the diameter ofmilk nucleus，uterine volume，ovarian volume and maximum follicle diameter between the two groups were significantly lower than those before treatment，and the values in the observation group wre significantly lower than those in the control group（P<0.05）. There were no significant differences in the levels of follicular estrogen（FSH），estradiol（E2）or luteinizing hormone（LH）between the two groups before treatment（P>0.05），and the levels in the two groups after treatment were significantly lower than those before treatment. There was no significant difference in plasma Kisspeptin level between the two groups before treatment（P>0.05），and the plasma Kisspeptin level in the two groups after treatment was significantly lower than that before treatment，and that in the observation group was significantly lower than that in the control group（P<0.05）.
Conclusion In the treatment of idiopathic central precocious puberty in girls，Zhibai Dihuang Pill combined with acupoint catgut embedding can effectively improve the growth，development and secondary sex characteristics of the children，and reduce the secretion of sex hormones and plasma Kisspeptin.
, authors=Yujing JIN, Shuai ZHAO, Fengping SUN, Ruiying REN, authorsList=Yujing JIN, Shuai ZHAO, Fengping SUN, Ruiying REN, authorCompany=null, correspAuthors=Fengping SUN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322912303900918685, articleId=1322912302130922385, tenantId=1146029695717560320, journalId=1255847919539208197, language=CN, title=加减知柏地黄丸联合穴位埋线对特发性中枢性性早熟女童性激素及血浆Kisspeptin水平的影响, columnId=1256183362172142382, journalTitle=中华中医药学刊, columnName=国家项目点击, runingTitle=null, highlight=null, articleAbstract=
目的 探究加减知柏地黄丸联合穴位埋线对特发性中枢性性早熟女童性激素及血浆Kisspeptin水平的影响。
方法 选择2021年6月—2022年12月于医院接受治疗的特发性中枢性性早熟女童72例为研究对象，按照随机数表法随机分成观察组和对照组，每组36例。观察组给予加减知柏地黄丸联合穴位埋线进行治疗，对照组患儿予醋酸亮丙瑞林3.75 mg，皮下注射；对比两组患儿的生长发育指标、第二性征、性激素水平及血浆Kisspeptin水平。
结果 治疗前后两组患儿身高、体质量差异均无统计学意义（P>0.05），治疗前两组患者骨龄指数差异无统计学意义（P>0.05），治疗后两组患儿骨龄指数均显著低于治疗前且观察组骨龄指数显著低于对照组（P<0.05）；治疗前两组患儿乳核直径、子宫容积、卵巢容积、最大卵泡直径均差异无统计学意义（P>0.05），治疗后两组患儿乳核直径、子宫容积、卵巢容积、最大卵泡直径均显著小于治疗前且观察组显著小于对照组（P<0.05）；治疗前两组患者的卵泡雌激素（FSH）、雌二醇（E2）、促黄体生成素（LH）水平差异无统计学意义（P>0.05），治疗后两组患者的FSH、E2、LH表达水平均显著低于治疗前且观察组显著低于对照组（P<0.05）；治疗前两组患儿血浆Kisspeptin水平差异无统计学意义（P>0.05），治疗后两组患儿血浆Kisspeptin水平均显著低于治疗前且观察组显著低于对照组（P<0.05）。
结论 加减知柏地黄丸联合穴位埋线治疗女童特发性中枢性性早熟能有效地改善患儿生长发育及第二性征，减少性激素及血浆Kisspeptin分泌。
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金玉晶（1982-），女，河南邓州人，副主任中医师，硕士，研究方向：中医药及中医外治治疗儿童生长发育相关研究。
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金玉晶（1982-），女，河南邓州人，副主任中医师，硕士，研究方向：中医药及中医外治治疗儿童生长发育相关研究。
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金玉晶（1982-），女，河南邓州人，副主任中医师，硕士，研究方向：中医药及中医外治治疗儿童生长发育相关研究。
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2、FSH和LH激素水平的影响及症状的改善研究, refAbstract=null)], funds=[Fund(id=1322912483618456426, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, awardId=2022ZX791, language=CN, fundingSource=国家中医药管理局中医药科学技术研究专项(2022ZX791), fundOrder=null, country=null), Fund(id=1322912483685565291, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, awardId=LHGJ20220723, language=CN, fundingSource=河南省医学科技攻关计划联合共建项目(LHGJ20220723), fundOrder=null, country=null), Fund(id=1322912483756868460, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, awardId=222102310281, language=CN, fundingSource=河南省科技攻关项目(222102310281), fundOrder=null, country=null), Fund(id=1322912483832365933, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, awardId=郑卫中管函〔2024〕5号, language=CN, fundingSource=郑州市中医药骨干人才培养项目(郑卫中管函〔2024〕5号), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322912475066270527, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, xref=null, ext=[AuthorCompanyExt(id=1322912475078853440, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, companyId=1322912475066270527, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital Zhengzhou Children's Hospital, Zhengzhou 450053, Henan, China), AuthorCompanyExt(id=1322912475124990785, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, companyId=1322912475066270527, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=郑州大学附属儿童医院，河南省儿童医院郑州儿童医院，河南 郑州 450053)])], figs=[ArticleFig(id=1322912482813150050, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 身高/（cm） | 体质量/（kg） | 骨龄指数 |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 36 | 121.23±12.91 | 123.46±19.15 | 25.67±6.42 | 28.85±5.71 | 1.32±0.41 | 1.21±0.33* |
| 对照组 | 36 | 120.87±12.85 | 123.79±19.06 | 25.25±7.27 | 29.13±8.86 | 1.30±0.38 | 1.01±0.43* |
| t值 | | 0.172 | 0.153 | 0.533 | 0.314 | 0.283 | 2.914 |
| P值 | | 0.432 | 0.439 | 0.298 | 0.377 | 0.479 | 0.004 |
), ArticleFig(id=1322912482930590563, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, language=CN, label=表1, caption=
两组特发性中枢性性早熟女童生长发育指标对比（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 身高/（cm） | 体质量/（kg） | 骨龄指数 |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 36 | 121.23±12.91 | 123.46±19.15 | 25.67±6.42 | 28.85±5.71 | 1.32±0.41 | 1.21±0.33* |
| 对照组 | 36 | 120.87±12.85 | 123.79±19.06 | 25.25±7.27 | 29.13±8.86 | 1.30±0.38 | 1.01±0.43* |
| t值 | | 0.172 | 0.153 | 0.533 | 0.314 | 0.283 | 2.914 |
| P值 | | 0.432 | 0.439 | 0.298 | 0.377 | 0.479 | 0.004 |
), ArticleFig(id=1322912483010282340, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 乳核直径/（cm） | 子宫容积/（mL） | 卵巢容积/（mL） | 最大卵泡直径/（mm） |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 36 | 3.81±1.09 | 2.04±1.11* | 3.47±1.37 | 2.90±0.79* | 2.93±1.24 | 2.16±1.19* | 5.64±1.71 | 4.11±1.19* |
| 对照组 | 36 | 3.76±1.02 | 2.38±0.97* | 3.52±1.25 | 3.23±0.98* | 2.88±1.17 | 2.57±1.03* | 5.72±1.80 | 4.64±1.22* |
| t值 | | 0.201 | 1.716 | 0.279 | 2.071 | 0.232 | 2.061 | 0.255 | 2.458 |
| P值 | | 0.792 | 0.042 | 0.390 | 0.041 | 0.817 | 0.041 | 0.800 | 0.015 |
), ArticleFig(id=1322912483094168421, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, language=CN, label=表2, caption=
两组特发性中枢性性早熟女童第二性征对比（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 乳核直径/（cm） | 子宫容积/（mL） | 卵巢容积/（mL） | 最大卵泡直径/（mm） |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 36 | 3.81±1.09 | 2.04±1.11* | 3.47±1.37 | 2.90±0.79* | 2.93±1.24 | 2.16±1.19* | 5.64±1.71 | 4.11±1.19* |
| 对照组 | 36 | 3.76±1.02 | 2.38±0.97* | 3.52±1.25 | 3.23±0.98* | 2.88±1.17 | 2.57±1.03* | 5.72±1.80 | 4.64±1.22* |
| t值 | | 0.201 | 1.716 | 0.279 | 2.071 | 0.232 | 2.061 | 0.255 | 2.458 |
| P值 | | 0.792 | 0.042 | 0.390 | 0.041 | 0.817 | 0.041 | 0.800 | 0.015 |
), ArticleFig(id=1322912483186443110, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | FSH/（mIU/mL） | E2/（pg/mL） | LH/（mIU/mL） |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 36 | 58.27±11.46 | 23.95±7.94* | 38.29±8.37 | 12.15±3.24* | 17.81±2.65 | 8.75±1.35* |
| 对照组 | 36 | 57.65±10.57 | 29.26±8.20* | 39.48±9.04 | 14.02±3.66* | 17.94±2.68 | 9.64±1.63* |
| t值 | | 0.238 | 2.791 | 0.580 | 3.037 | 0.207 | 2.523 |
| P值 | | 0.406 | 0.003 | 0.282 | 0.003 | 0.418 | 0.007 |
), ArticleFig(id=1322912483295495015, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, language=CN, label=表3, caption=
两组特发性中枢性性早熟女童性激素水平对比（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | FSH/（mIU/mL） | E2/（pg/mL） | LH/（mIU/mL） |
|---|
| 治疗前 | 治疗后 | 治疗前 | 治疗后 | 治疗前 | 治疗后 |
|---|
| 观察组 | 36 | 58.27±11.46 | 23.95±7.94* | 38.29±8.37 | 12.15±3.24* | 17.81±2.65 | 8.75±1.35* |
| 对照组 | 36 | 57.65±10.57 | 29.26±8.20* | 39.48±9.04 | 14.02±3.66* | 17.94±2.68 | 9.64±1.63* |
| t值 | | 0.238 | 2.791 | 0.580 | 3.037 | 0.207 | 2.523 |
| P值 | | 0.406 | 0.003 | 0.282 | 0.003 | 0.418 | 0.007 |
), ArticleFig(id=1322912483370992488, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 血浆Kisspeptin | t值 | P值 |
|---|
| 治疗前 | 治疗后 |
|---|
| 观察组 | 36 | 1.91±0.24 | 1.42±0.16 | 10.192 | <0.001 |
| 对照组 | 36 | 1.88±0.21 | 1.64±0.18 | 5.206 | <0.001 |
| t值 | | 0.564 | 5.481 | | |
| P值 | | 0.287 | <0.001 | | |
), ArticleFig(id=1322912483467461481, tenantId=1146029695717560320, journalId=1255847919539208197, articleId=1322912302130922385, language=CN, label=表4, caption=
两组特发性中枢性性早熟女童血浆Kisspeptin水平对比（
±s）
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 例数 | 血浆Kisspeptin | t值 | P值 |
|---|
| 治疗前 | 治疗后 |
|---|
| 观察组 | 36 | 1.91±0.24 | 1.42±0.16 | 10.192 | <0.001 |
| 对照组 | 36 | 1.88±0.21 | 1.64±0.18 | 5.206 | <0.001 |
| t值 | | 0.564 | 5.481 | | |
| P值 | | 0.287 | <0.001 | | |
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