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Role of exosomes derived from mesenchymal stem cells in treatment of colorectal cancer
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Zhao Guo1, Haoyan Zhuang1, Xuewen Shi2
Chinese Journal of Tissue Engineering Research | 2025, 29(36) : 7872 - 7879
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Chinese Journal of Tissue Engineering Research | 2025, 29(36): 7872-7879
• Review •
Role of exosomes derived from mesenchymal stem cells in treatment of colorectal cancer
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Zhao Guo1, Haoyan Zhuang1, Xuewen Shi2
Affiliations
  • 1First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250000, Shandong Province, China
  • 2Department of Anorectal Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, Shandong Province, China
Published: 2025-12-28 doi: 10.12307/2025.555
Outline
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BACKGROUND:

Currently, the treatment methods for colorectal cancer include surgical resection and chemotherapy. However, the subsequent quality of life of patients cannot be improved due to the multiple surgical complications and drug resistance in the later stage of chemotherapy.

OBJECTIVE:

To review the mechanism of action, latest progress and existing problems of exosomes derived from mesenchymal stem cells in the treatment of colorectal cancer.

METHODS:

PubMed, CNKI and WanFang databases were searched for relevant literature using the search terms of “mesenchymal stem cells exosomes, colorectal cancer, chemotherapy, treatment” in Chinese and English, respectively. Finally, 96 articles were included for analysis.

RESULTS AND CONCLUSION:

(1) Mesenchymal stem cell-derived exosomes play different roles in the treatment of colorectal cancer mainly through the microRNAs and long-chain non-coding RNAs carried by themselves to mediate different signaling pathways. (2) Mesenchymal stem cell-derived exosomes are highly stable and biocompatible, which makes them excellent carriers of therapeutic drugs. (3) Mesenchymal stem cell-derived exosomes have different effects on resistance to different types of chemotherapeutic agents.

mesenchymal stem cell  /  exosome  /  colorectal cancer  /  chemotherapy  /  mechanism  /  potential target  /  carrier  /  engineered stem cell  /  review
Zhao Guo, Haoyan Zhuang, Xuewen Shi. Role of exosomes derived from mesenchymal stem cells in treatment of colorectal cancer[J]. Chinese Journal of Tissue Engineering Research, 2025 , 29 (36) : 7872 -7879 . DOI: 10.12307/2025.555
Funding
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  • Shandong Province Traditional Chinese Medicine Science and Technology Development Project(2019-0187)
  • Qilu Traditional Chinese Medicine Advantage Specialty Cluster Construction Project(YWC2022ZKJQ0003)
Appendix
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Year 2025 volume 29 Issue 36
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67
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Article Info
doi: 10.12307/2025.555
  • Receive Date：2024-04-22
  • Online Date：2026-04-02
  • Published：2025-12-28
Article Data
Affiliations
History
  • Received：2024-04-22
  • Revised：2024-10-28
  • Accepted：2024-09-21
Funding
Shandong Province Traditional Chinese Medicine Science and Technology Development Project(2019-0187)
Qilu Traditional Chinese Medicine Advantage Specialty Cluster Construction Project(YWC2022ZKJQ0003)
Affiliations
    1First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250000, Shandong Province, China
    2Department of Anorectal Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, Shandong Province, China

Corresponding:

Shi Xuewen, MD, Chief physician, Department of Anorectal Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, Shandong Province, China
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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