OBJECTIVE To analyze the characteristics of clinical pharmacists' participation in consultation cases of infectious diseasesin the intensive care unit (ICU), summarize the experience and effect and provide reference for promoting the rational use of antiinfection drugs in ICU. METHODS A retrospective analysis was conducted on the cases of clinical pharmacists participating in ICU infection consultation from November 2021 to MAY 2023, and the basic data, common etiology, consultation purpose, adoption rate, and prognosis of these cases were statistically summarized. RESULTS Among the 72 consultations, there were 60 patients with positive etiological examination results and 73 strains of virus, including 35 strains of Gram negative bacteria, 28 strains of Gram positive bacteria, and 10 strains of fungi. The top three bacteria were Pseudomonas aeruginosa (23.61%), Staphylococcus aureus (16.67%), and Klebsiella pneumoniae (9.72%). The top three clinical consultation purposes were the selection of antibacterial drugs for positive bacterial/fungal culture (47.22%), the adjustment of medication due to poor early protocol (22.22%), and the selection of antibacterial drugs for specific site infections (12.50%). The top three consultation opinions given by pharmacists were 24 cases of adjusting the type of antibacterial drugs, 16 cases of adding antibacterial drugs, and 16 cases of continuing the original antiinfection treatment plan. The consultation opinions were adopted in 62 cases and not adopted in 10 cases, with an adoption rate of 86.11%. Among them, the treatment effectiveness rate of patients with accepted opinions was 74.19%, and that of patients without accepted opinions was 30.00%. The prognosis of patients with accepted opinions was better (P<0.05). CONCLUSION Due to the particularity of ICU patients and the limitation of drug selection, antiinfection treatment is difficult. Clinical pharmacists participate in consultation of ICU infected patients and formulate drug treatment plans can improve the cure rate of infectious diseases, which is of great significance to promote the rational use of antibiotics and improve the prognosis of patients.