PDF
Full
Outline
OBJECTIVE To investigatte antitumor agent epirubicin hydrochloride loaded in TempSLE in vitro/in vivo antitumor activity and provide evidence in clinical use of transcatheter arterial chemoembolization(TACE). METHODS In this study, the TempSLE was selected as the embolic agent, and epirubicin hydrochloride for injection was used as the chemotherapy drug. Epirubicin hydrochloride TempSLE was prepared and its physical and chemical properties and drug release behavior were investigated. Human liver cancer HepG2 cells were selected. The anti-tumor activity of epirubicin hydrochloride TempSLE was evaluated in vitro HepG2 cells. The anti-tumor efficacy of EPI TempSLE in HepG2 tumor-bearing nude mice was evaluated by singly administered EPI TempSLE via peri-tumoral injection. RESULTS The method for preparation of EPI TempSLE was simple; the added EPI did not affect the temperature-sensitive characteristics of TempSLE. The released EPI from EPI TempSLE was about 80% at 24 h time point, after that, EPI was sustained release for 216h and nearly released 100%; the in vitro antitumor activity of EPI TempSLE in HepG2 cells was similar with that of EPI; the in vivo anti-tumor efficacy of EPI TempSLE was observed in HepG2 tumor-bearing nude mice. CONCLUSION The obtained results would help to support the clinical application of epirubicin hydrochloride TempSLE in TACE.
PDF
87
45
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
