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OBJECTIVE To explore and analyze the occurrence of pustular psoriasis caused by ustekinumab in order to provide references for clinical safety drug use. METHODS The case report of ustekinumab-induced pustular psoriasis published in PubMed, Embase, CNKI, Wanfang and VIP were searched for statistical analysis from the establishment of each database to December 2023. RESULTS A total of 8 patients were included in 8 literatures, including 3 males (37.50%) and 5 females (62.50%), aged from 30 to 58 years. Pustular psoriasis occurred 2 days to 10 weeks after the first treatment with ustekinumab, of which 4 cases (50.00%) occurred after the first injection. The lesions include trunk(50.00%), limbs(50.00%), back(12.50%), palm(50.00%), sole of foot(25.00%) and scalp(12.50%). The lesions are scattered in red spots, exfoliated plaques or scales, scattered in pustules, with or without inflammation, pain and pruritus. The prognosis was good. Five patients (62.50%) got better quickly after treatment with immunosuppressive agents and glucocorticoids after drug withdrawal. The total treatment cycle was 1-8 weeks. All the patients who did not stop treatment also improved, but the probability of contradictory pustular lesions occurring again was high (66.67%). CONCLUSION In the process of clinical use of ustekinumab, the potential psoriasis, especially pustular psoriasis should be realized. By collecting the drug treatment history, clarifying the time relationship, identifying other possible triggering factors, and making accurate diagnosis with the help of clinical symptoms and histopathological examination. If necessary, stop the drug or adjust the treatment plan in time to ensure drug safety.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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