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Methyltransferase-like proteins (METTL) are a kind of enzyme proteins that exist widely in human body, with a binding domain of nucleic acids, proteins, and other small molecules. METTL catalyzes methylation using S-adenosylmethionine (SAM) as a substrate. Methylation is one of the important modifications of proteins and nucleic acids and is one of the important topics in epigenetic. Members of the METTL family are considered to be methyltransferases in the methylation of nucleic acids and proteins, and understanding the mechanisms by which these potential enzymes act can help understand their functions and substrate specificity. With the development of research, it has been found that METTL family is abnormally expressed in a variety of tumor diseases, and its relationship with tumor diseases is clarified. It can be used as a target of molecular therapy and plays an important role in tumor prognosis. In this review, the classification, mechanism of action and relationship between METTL family and tumor were reviewed in order to provide new ideas and new targets for tumor pathogenesis and diagnosis and treatment.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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