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Progress on Application of Silk Fibroin Nanocarriers in Oncology Drug Delivery System
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Xuejun WANG1, 2, Mingjuan LI1, Jie ZHANG1, Huan GAO1, Gensheng YANG2, Baoyue DING1, *
Chinese Pharmaceutical Journal | 2024, 59(5) : 377 - 384
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Chinese Pharmaceutical Journal | 2024, 59(5): 377-384
Progress on Application of Silk Fibroin Nanocarriers in Oncology Drug Delivery System
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Xuejun WANG1, 2, Mingjuan LI1, Jie ZHANG1, Huan GAO1, Gensheng YANG2, Baoyue DING1, *
Affiliations
  • 1 Medical College, Jiaxing University, Jiaxing 314001, China
  • 2 School of pharmacy, Zhejiang University of Technology, Hangzhou 310014, China
Published: 2024-03-08
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Silk fibroin is a type of natural polymer that has good biocompatibility, biodegradability and is also easy to modify. It also possesses low cytotoxicity and is non-immunogenic and therefore it is widely used for the delivery of anti-tumor drugs. Most anti-tumor drugs suffer from low solubility, poor pharmacokinetics and high off-target toxicity. Therefore finding and developing appropriate drug delivery systems is urgently requires to solve these problems and improve the treatment of patients. This paper briefly reviews the structure and characteristics of silk fibroin, the preparation and the different types as well as the research progress of silk fibroin nanocarriers for anti-tumor drugs delivery. This paper also summerizes the research progress of silk fibroin nanocarrier application in photodynamic, photothermal and gene therapy for the treatment of malignant tumors. Based on our summery, silk fibroin has prospects for a broad application as a delivery system of anti-tumor drugs. Therefor it seems that silk fibroin will be a promising and important carrier material for novel formulations of anti-tumor drugs.

silk fibroin  /  nanocarrier  /  anti-tumor drug delivery system  /  photodynamic therapy  /  photothermal therapy  /  gene therapy
Xuejun WANG, Mingjuan LI, Jie ZHANG, Huan GAO, Gensheng YANG, Baoyue DING. Progress on Application of Silk Fibroin Nanocarriers in Oncology Drug Delivery System[J]. Chinese Pharmaceutical Journal, 2024 , 59 (5) : 377 -384 .
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Article Info
  • Receive Date：2022-09-15
  • Online Date：2026-04-08
  • Published：2024-03-08
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  • Received：2022-09-15
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    1 Medical College, Jiaxing University, Jiaxing 314001, China
    2 School of pharmacy, Zhejiang University of Technology, Hangzhou 310014, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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