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Determination of Relative Correction Factor Based on Quantitative Nuclear Magnetic Resonance and Chromatography
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Jiaojiao WANG1, Zhiwei GE1, Shiyan LU1, Jingqun YUAN1, yu TANG2, Yingchao WANG2, *
Chinese Pharmaceutical Journal | 2024, 59(5) : 446 - 450
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Chinese Pharmaceutical Journal | 2024, 59(5): 446-450
Determination of Relative Correction Factor Based on Quantitative Nuclear Magnetic Resonance and Chromatography
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Jiaojiao WANG1, Zhiwei GE1, Shiyan LU1, Jingqun YUAN1, yu TANG2, Yingchao WANG2, *
Affiliations
  • 1 Analysis Center of Agrobiology and Environmental Sciences, Zhejiang University, Hangzhou 310058, China
  • 2 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
Published: 2024-03-08
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OBJECTIVE To establish a method for determining the relative correction factor (RCF) based on quantitative nuclear magnetic resonance (qNMR) and chromatography, and explore the suitability and accuracy of the method. METHODS The spectral constants of all excited atoms are the same in the qNMR experiment. The ratio of the amount of the substances was calculated by qNMR, and the chromatographic peak area was determined by chromatography. Then the RCF was calculated from the above two results. Taking the correction factor of dimethyl terephthalate relative to coumarin as an example, the reliability of the method was verified. Then the method was used to calculate the RCF of pre-vitamin D3. RESULTS The RCF values obtained by slope ratio method, multi-point method, fusion technology were the same. The experimental result verified the reliability of the method. In addition, this method was used to determine the RCF of pre-vitamin D3 relative to vitamin D3. The results were consistent with those reported in the literature, which further proved that the calculation method was accurate and reliable. CONCLUSION This method provides a new idea for calculating RCF in the absence of reference substance, and solves the problem of difficult determination of RCF of compounds with unstable properties or unavailable standards.

quantitative nuclear magnetic resonance  /  liquid chromatography  /  relative correction factor  /  vitamin D3  /  pre-vitamin D3
Jiaojiao WANG, Zhiwei GE, Shiyan LU, Jingqun YUAN, yu TANG, Yingchao WANG. Determination of Relative Correction Factor Based on Quantitative Nuclear Magnetic Resonance and Chromatography[J]. Chinese Pharmaceutical Journal, 2024 , 59 (5) : 446 -450 .
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Article Info
  • Receive Date：2023-07-05
  • Online Date：2026-04-08
  • Published：2024-03-08
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  • Received：2023-07-05
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Affiliations
    1 Analysis Center of Agrobiology and Environmental Sciences, Zhejiang University, Hangzhou 310058, China
    2 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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