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Autophagy is a kind of programmed cell death that maintains metabolic and energetic homeostasis in organisms, which involves degradation of proteins, organelles, and other components. Mitophagy is a highly selective autophagy, which achieves its own metabolites and energy requirements by degrading excess or damaged mitochondria. Mitophagy plays an important role in the development of diseases, as one of selective autophagy most studied up to now. Some compounds have been found to induce mitophagy in cells through different mitochondrial signaling pathways, affecting the disease. In the current review, we summarized the mechanism of mitophagy induction and compounds that induce mitophagy are summarized, with the aim to provide a reference for the research and development of new drugs targeting mitochondria.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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