PDF
Full
Outline
Drug combination therapy is the combination of two or more drugs in the form of "formulas" to achieve the effect of increasing efficacy and reducing toxicity. It has achieved good results in the treatment of various complex diseases and overcoming drug resistance in patients. In the past few decades, Western medicine has gradually increased its efforts in the development of combination drugs and has achieved good results in the discovery and screening techniques of combination drugs. Traditional Chinese medicine (TCM), with the characteristics of “multi-components, multi-targets, and multi-pathways”, is a reliable ingredient library for synergistic drug combinations due to its years of clinical use. This paper summarizes the application of combinatorial drug discovery methods in the past decade, including systems biology, histology, machine learning, and mathematical modeling. It also explains the advantages and shortcomings of each method. It aims to provide new ideas and approaches for identifying potential combinations of active ingredients in traditional Chinese medicine, reducing blind tests and studies, and evaluating the interaction relationships of drug combinations.
PDF
113
54
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
