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OBJECTIVE To establish a high-throughput qualitative analysis method for the Zhuang medicine Tongfeng Li'an Capsule use by Q-exactive orbitrap HRMS mass spectrometry. METHODS HPLC part on GOLD C18 column(2.1 mm×100 mm,1.9 μm) and the gradient elution was performed with mobile phase consisting of 0.1% formic acid acetonitrile -0.1% formic acid aqueous solution. Flow velocity was 0.3 mL·min-1, injection volume was 3 μL, column temperature was maintained at 35 ℃, mass spectrometry part used HESI ion source, Full MS/dd-MS2 mode, ion scan range 100-1 500, vertex excitation for 2-8 s. RESULTS A total of 49 compounds were identified from Tongfeng Li'an Capsule by orbitrap HRMS, including 19 phenylpropanoids, 11 terpenes, 10 organic acids, 3 phenols, 2 anthraquinone, 2 alkaloids and vitamins, and 2 sugars and glycols. Among them, 46 compounds were identified for the first time from Tongfeng Li'an Capsule. CONCLUSION Data for high-resolution gather with orbitrap HRMS method was the first time comprehensive qualitative characterization conducted on Tongfeng Li'an Capsule, This provides a material basis and new scientific research basis and reference for its multi-component analysis application, quality standard improvement, and pharmacological research.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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