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OBJECTIVE To investigate the effects of age, gender, body mass index (BMI), type of epilepsy, dosage and combined medication on the steady-state serum concentration of perampanel in children with epilepsy. METHODS A total of 95 serum samples from 4 to 14 years old children with epilepsy who were admitted to our hospital from 2019 to 2023 and took perampanel regularly were collected. The serum concentration was determined by high performance liquid chromatography. The influence of factors such as gender, BMI, dosage and combined medication on the concentration were analyzed. RESULTS The children aged 4.25-14 (7.25±3.99) years. The serum concentration of perampanel was 0.13-0.99(0.47±0.36)μg·mL-1. There were no significant differences in the serum concentration and ratio of concentration dose (CDR) of perampanel among different age groups and gender groups (P>0.05). The CDRs of patients of 18.5≤BMI<24.0 group were significantly higher than those of BMI<18.5 group (t=-1.207, P<0.05). The combination of drug had no significant effects on the dosage, blood concentration and CDR of perampanel (P>0.05). The correlation between perampanel concentration and dose was poor (r=0.113). CONCLUSION In the course of using perampanel for the treatment of epilepsy in children, it is necessary to conduct therapeutic drug monitoring, so that the concentration can be controlled within the therapeutic range to ensure clinical efficacy and reduce the incidence of adverse reactions.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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