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OBJECTIVE To identify and evaluate the risk signals of tislelizumab in non-small-cell lung cancer (NSCLC) patients, so as to provide basis for future management of irAEs and better tumor immunotherapy in NSCLC patients. METHODS The clinical data of NSCLC patients who received tislelizumab in Peking University People's Hospital from April 2021 to April 2023 were retrospectively analyzed. The occurrence of irAEs during tislelizumab treatment was observed, the incidence of irAEs was summarized, and the clinical features of irAEs and non-irAEs groups were compared. RESULTS Sixty-eight NSCLC patients received tislelizumab, of whom 22 (32.35%) developed 32 irAEs. The main manifestations were pulmonary toxicity (17.65%), skin toxicity (11.76%), endocrine toxicity (5.88%), gastrointestinal toxicity (4.41%), cardiovascular toxicity (4.41%), and hematological toxicity (2.94%). The median duration of irAEs was 79 d (1-706 d). Thirteen cases (59.09%) were treated with glucocorticoids. Comparison of the clinical characteristics of irAEs group and non-irAEs group showed that the incidence of irAEs in patients with hepatic insufficiency was higher (P<0.05), the other differences were not statistically significant (P>0.05). CONCLUSION irAEs involve multiple systems/organs, so attention should be paid to the management of immune-related toxicity, timely detection, and treatment of irAEs, to achieve better effects of tumor immunotherapy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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