Home Journals Articles Updates About
CN
image
收藏切换
Exploring Inflammation-Related Targets and Advances in the Treatment of Nonalcoholic Steatohepatitis
收藏切换
PDF
Xin LIU1, Ya LUO1, Minxuan XU2, 3, Chenxu GE2, 3, Jianhui LIU1, *, Jun TAN2, 3, *
Chinese Pharmaceutical Journal | 2024, 59(13) : 1173 - 1185
Less
收藏切换
Chinese Pharmaceutical Journal | 2024, 59(13): 1173-1185
Exploring Inflammation-Related Targets and Advances in the Treatment of Nonalcoholic Steatohepatitis
Full
Xin LIU1, Ya LUO1, Minxuan XU2, 3, Chenxu GE2, 3, Jianhui LIU1, *, Jun TAN2, 3, *
Affiliations
  • 1 School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China
  • 2 School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China
  • 3 Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, Chongqing 400067, China
Published: 2024-07-08 doi: 10.11669/cpj.2024.13.001
Outline
收藏切换

Non-alcoholic steatohepatitis (NASH), a severe subtype of non-alcoholic fatty liver disease (NAFLD), is emerging as a major health threat worldwide. However, due to its complex pathogenesis, there are currently no marketed drugs for NASH. The disease is not only involved in fat accumulation, but also accompanied by inflammation and fibrosis processes, in which inflammation plays an important role in the progression of NASH, long-term inflammatory response, can promote liver fibrosis and lipid homeostasis imbalance. Therefore, inhibiting inflammation is of great significance in improving NASH. This review systematically reviews the mechanism of action of inflammatory signaling pathways such as mitogen-activated protein kinase(MAPK), nuclear factor-κB(NF-κB), inactive rhomboid-like protein 2(iRhom2) and inflammasome in the development of NASH, and the current research status of related drugs such as Selonsertib, SHR0302 and fisetin, and further discusses the research progress of new targets for the treatment of NASH. It aims to provide new ideas for the research and development of drugs for NASH.

nonalcoholic steatohepatitis(NASH)  /  inflammatory signaling pathway  /  nuclear factor-κB(NF-κB)  /  inactive rhomboid like protein 2(iRhom2)  /  inflammasome
Xin LIU, Ya LUO, Minxuan XU, Chenxu GE, Jianhui LIU, Jun TAN. Exploring Inflammation-Related Targets and Advances in the Treatment of Nonalcoholic Steatohepatitis[J]. Chinese Pharmaceutical Journal, 2024 , 59 (13) : 1173 -1185 . DOI: 10.11669/cpj.2024.13.001
Appendix
Less
Year 2024 volume 59 Issue 13
PDF
81
38
Cite this Article
BibTeX
Article Info
doi: 10.11669/cpj.2024.13.001
  • Receive Date：2024-02-21
  • Online Date：2026-01-14
  • Published：2024-07-08
Article Data
Affiliations
History
  • Received：2024-02-21
Funding
Affiliations
    1 School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China
    2 School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China
    3 Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, Chongqing 400067, China
References
Share
https://castjournals.cast.org.cn/joweb/zgyxzz/EN/10.11669/cpj.2024.13.001
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House