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UPLC-MS/MS Multi-Index Component Analysis of Red Ginseng Combined with Chemometrics and EW-TOPSIS Method to Evaluate the Quality of Shenmai Granules
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Yaru LIU1, 2, Rong LEI2, *, Jian SU2, Yongli LIU1, 2, *
Chinese Pharmaceutical Journal | 2024, 59(15) : 1445 - 1452
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Chinese Pharmaceutical Journal | 2024, 59(15): 1445-1452
UPLC-MS/MS Multi-Index Component Analysis of Red Ginseng Combined with Chemometrics and EW-TOPSIS Method to Evaluate the Quality of Shenmai Granules
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Yaru LIU1, 2, Rong LEI2, *, Jian SU2, Yongli LIU1, 2, *
Affiliations
  • 1 Hebei Medical University, Shijiazhuang 050017, China
  • 2 Hebei Key Laboratory for Quality Evaluation and Standard of Traditional Chinese Medicine, Hebei Institute for Drug and Medical Device Control, Shijiazhuang 050227, China
Published: 2024-08-08 doi: 10.11669/cpj.2024.15.012
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OBJECTIVE To establish a UPLC-MS/MS method for simultaneous determination of 14 components in Shenmai granules, and analyze the quality differences of red ginseng feed from different manufacturers. METHODS Shimadzu Shim-pack gist C18(2.1 mm×100 mm,2 μm) chromatographic column with acetonitrile-water as the mobile phase were used to determine the contents of 14 saponin components in 71 batches of Shenmai Granules. And then analyzed the main material basis affecting the difference in red ginseng feeding in Shenmai granules combined with chemometrics and evaluated the quality of red ginseng feeding in Shenmai granules from different manufacturers combined with EW-TOPSIS. RESULTS The concentrations of 14 components had a good linear relationship (r≥0.998 5); and the average recovery rate was 95.6%-105.0%(RSD<4.7%). According to the analysis of chemometrics and EW-TOPSIS, the samples produced by the three manufacturers were grouped into three categories, among which the quality of red ginseng feeding by manufacturer B was generally good, and the red ginseng feeding by manufacturer C was adulterated. CONCLUSION This method is specific, sensitive, efficient, and reliable, and can be used for the quality control of Shenmai granules.

Shenmai granule  /  red ginseng  /  quality evaluation  /  chemometrics  /  EW-TOPSIS
Yaru LIU, Rong LEI, Jian SU, Yongli LIU. UPLC-MS/MS Multi-Index Component Analysis of Red Ginseng Combined with Chemometrics and EW-TOPSIS Method to Evaluate the Quality of Shenmai Granules[J]. Chinese Pharmaceutical Journal, 2024 , 59 (15) : 1445 -1452 . DOI: 10.11669/cpj.2024.15.012
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Year 2024 volume 59 Issue 15
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Article Info
doi: 10.11669/cpj.2024.15.012
  • Receive Date：2024-06-30
  • Online Date：2026-01-14
  • Published：2024-08-08
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  • Received：2024-06-30
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Affiliations
    1 Hebei Medical University, Shijiazhuang 050017, China
    2 Hebei Key Laboratory for Quality Evaluation and Standard of Traditional Chinese Medicine, Hebei Institute for Drug and Medical Device Control, Shijiazhuang 050227, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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