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OBJECTIVE To evaluate the distribution and clearance of tumor infiltrating lymphocytes (TIL) in NOG mice. METHODS Eighty-four NOG mice were used, divided into control group and test group. The mice were given a single tail vein injection. After administration blood was collected and organs were taken at different time points, flow cytometry and real-time quantitative PCR (qPCR) were used to detect the distribution of cells in the blood and different organs. RESULTS After 1-2 d of administration, the number of CD3+, CD3+CD4+, and CD3+CD8+cells in the blood reached their peaks. At the same time, qPCR showed that TIL was mainly distributed in tissues such as lungs, blood, and liver, with less distribution in other tissues. On day 42 after administration, gene copies of most tissues were below the lower limit of quantitation. CONCLUSION Single tail vein injection of TIL in NOG mice is mainly distributed in the lungs, blood, and liver, and its duration in vivo does not exceed 42 d.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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