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Preparation, Characterization and in Vitro Release of Scoparone PLGA Microspheres
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Meng MENG1, Hao WANG1, Qinqin XIE1, Jiajia LIU2, 3, Weiping XU1, 2, 4, *
Chinese Pharmaceutical Journal | 2024, 59(20) : 1948 - 1955
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Chinese Pharmaceutical Journal | 2024, 59(20): 1948-1955
Preparation, Characterization and in Vitro Release of Scoparone PLGA Microspheres
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Meng MENG1, Hao WANG1, Qinqin XIE1, Jiajia LIU2, 3, Weiping XU1, 2, 4, *
Affiliations
  • 1 School of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230012, China
  • 2 Institute of Geriatrics, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei 230001, China
  • 3 Ophthalmology Department, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei 230001, China
  • 4 Key Laboratory of Tumor Immunology and Nutritional Therapy of Anhui Province, Hefei 230001, China
Published: 2024-10-22 doi: 10.11669/cpj.2024.20.009
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OBJECTIVE To prepare and characterize scoprone-loaded PLGA microspheres. METHODS Scoprone-loaded PLGA microspheres were constructed by a O/W emulsion-solvent evaporation method.Their surface morphology, encapsulation rate and drug loading of microspheres were the main evaluation indexes. Based on single factor experiment,the optimum preparation conditions of PLGA microspheres were obtained through central composite design. RESULTS Scoprone-loaded PLGA microspheres were light yellow powder and spherical in shape with smooth surface with size 2.94 μm.Scoprone was loaded into PLGA microspheres with drug loading(4.28%)and encapsulation efficiency(47.03%). CONCLUSION Scoprone-loaded PLGA microspheres are constructed successfully. The particle size of microspheres meets the requirements of intraocular vitreous cavity injection, and has good slow-release performance under simulated in vitro environment. The preparation method is accurate and reliable, and can provide a new dosage form for the treatment of diabetic retinopathy.

scoparone  /  slow-release microsphere  /  emulsion solvent volatilization  /  polylactic acid-glycolic acid copolymer  /  central compositedesign and response surface methodology
Meng MENG, Hao WANG, Qinqin XIE, Jiajia LIU, Weiping XU. Preparation, Characterization and in Vitro Release of Scoparone PLGA Microspheres[J]. Chinese Pharmaceutical Journal, 2024 , 59 (20) : 1948 -1955 . DOI: 10.11669/cpj.2024.20.009
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doi: 10.11669/cpj.2024.20.009
  • Receive Date：2023-09-21
  • Online Date：2025-12-30
  • Published：2024-10-22
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  • Received：2023-09-21
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Affiliations
    1 School of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230012, China
    2 Institute of Geriatrics, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei 230001, China
    3 Ophthalmology Department, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei 230001, China
    4 Key Laboratory of Tumor Immunology and Nutritional Therapy of Anhui Province, Hefei 230001, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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