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OBJECTIVE To systematically evaluate the effectiveness and safety of safflower yellow for injection (SYI) in acute ischemic stroke (AIS). METHODS Computer searches were conducted on CNKI, Wanfang Database, VIP.com, Chinese Biomedical Literature Database, PubMed, Embase, Web of Science and Cochrane Library for randomized controlled trials (RCTs) of SYI combined with conventional Western medicine treatment as experimental group (EG) and conventional Western medicine treatment as control group (CG). The Cochrane risk of bias assessment tool was used to evaluate the methodological quality of included studies. Statistical analysis was performed using R4.3.1 software. RESULTS A total of 29 RCTs were included. Meta-analysis results showed that compared with the CG group, the total effective rate of the EG group was higher (P<0.000 1), the patients' NIHSS, Barthel, IL-8, IL-6, plasma viscosity, and hematocrit indexes were improved (P<0.05); while in terms of NO and FIB indexes, there was no statistically significant difference between the two groups (P>0.05). In terms of safety, the total incidence of adverse drug reactions in the EG group was lower than that in the CG group (P=0.001 8). The results of sensitivity analysis and publication bias analysis showed that except for the fact that the incidence of adverse reactions reversed to a point had no statistically significant difference between the two groups (P=0.173 4), the results obtained in the study were basically stable, and the possibility of publication bias was small. CONCLUSION Compared with conventional treatment, SYI combined with conventional treatment is generally more effective in terms of effectiveness and does not increase the risk of adverse reactions.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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