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Age-related macular degeneration (AMD) is a degenerative retinal disease. AMD is divided into two major forms: dry (atrophic) AMD and wet (exudative) AMD. The most common treatment for wet AMD is intravitreal injection of anti-vascular endothelial growth factor drugs. However, the treatment can only relieve but not care, and there are some patients who aren’t adapted to this treatment of administration. The application of nanotechnology offers new strategies for improving drug delivery in AMD, where polymeric nanoparticles can provide sustained drug release, can be modified to target the lesion and increase drug target site deposition, can penetrate the ocular barrier and extend drug retention times. This paper reviews the current research advances in polymeric nanoparticles-based drug delivery systems for the treatment of AMD, providing a viable reference to the treatment of AMD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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