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OBJECTIVE To investigate the terpenoid constituents from the fresh-used leaves of Artemisia argyi Levl. et Vant. and their anti-inflammatory activities. METHODS Modern phytochemical separation techniques such as high performance preparative liquid chromatography (HPLC) were used to isolate the 95% ethanol extract of the fresh leaves from A. argyi and to identify the structure by combining physicochemical properties with MS and NMR data. The anti-inflammatory activity of terpenoids was evaluated by the inhibitory ability of nitric oxide (NO) release from LPS-induced RAW264.7 macrophages. RESULTS Fifteen terpenoids were isolated from the fresh leaves of A. argyi and identified as artanomaloide (1), dehydroleucodin (2), tamaulipin-B acetate (3), moxartenolide (4), yomogin (5), costic acid (6), costic acid methyl ester(7), PBI(8), (-)-3-hydroxy-β-ionone(9), pubinernoid A(10), subamone(11), artefrigin(12), cassipourol(13), 3β-acetoxy-24-oxo-dammara-20, 25-diene (14), dammara-20,24-dien-3β-ol acetate (15). The IC50 values of the anti-inflammatory activity of compounds 1-12 ranged from (1.27±0.02) to (17.55±0.13) μmol·L-1. CONCLUSION The fresh leaves from A. argyi are more abundant in terpenoids with anti-inflammatory activity, among which compounds 3 and 7-14 are isolated for the first time, and this kind of components can be applied in the development of pharmaceutical and health products.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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