PDF
Full
Outline
Triptolide (TP), also known as triptolide alcohol, is an epoxidised diterpene lactone compound extracted from the xylem of Tripterygium wilfordii Hook. f., a plant of the Weseraceae family. As the main active ingredient in Tripterygium wilfordii Hook. f. extracts, it has been proved to have immunosuppression, anti-tumor, anti-inflammation and other pharmacological effects. However, the development of triptolide has been limited due to its poor water solubility, high toxicity, obvious adverse reactions and low bioavailability. Therefore, researchers have optimised the structure of triptolide with the hope to improve its physicochemical properties. By now, the structure optimization has mainly been focused on sites like C-5,6, C-14, C-16, C-20, epoxy groups, unsaturated five-membered lactone ring. This paper summarizes the researches related to the structure optimization and their biological activity of the above reactive sites, which provides new thoughts for the structure-activity relationship and clinical application of triptolide.
PDF
313
247
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
