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Chemotherapy induced nausea and vomiting (CINV) is the most common adverse reaction in cancer patients during chemotherapy. 5-HT3 receptor antagonists are recommended as the first-line drugs against CINV. However, the commonly used clinical dosage forms of 5-HT3 receptor antagonists are mainly oral and intravenous administration, among which intravenous administration is easy to produce adverse reactions and requires professional medical operation. Oral administration has first-pass effect, especially for patients with severe vomiting after chemotherapy, so the commonly used clinical dosage forms have certain defects and limited clinical application. Transdermal drug delivery system has the advantages of avoiding gastrointestinal first-pass effect, less toxic and side effects, and good patient compliance, so the transdermal drug delivery system of anti-tumor nausea and vomiting drugs has been widely concerned and studied. In this paper, the research status of transdermal delivery of 5-HT3 receptor antagonists at home and abroad is reviewed, which provides reference for the research and development of new preparations and new delivery routes of these drugs.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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