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Research Progress in the Use of Cell Line and Organoid Models for Studying Inflammatory Bowel Disease
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Pan LIU1, 2, Xueling LIU2, Qingwei ZHAO2, *
Chinese Pharmaceutical Journal | 2024, 59(17) : 1558 - 1564
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Chinese Pharmaceutical Journal | 2024, 59(17): 1558-1564
Research Progress in the Use of Cell Line and Organoid Models for Studying Inflammatory Bowel Disease
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Pan LIU1, 2, Xueling LIU2, Qingwei ZHAO2, *
Affiliations
  • 1 School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
  • 2 Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine for Clinical Evaluation and Translational Research, Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Published: 2024-09-08 doi: 10.11669/cpj.2024.17.002
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It is important to select a suitable in vitro experimental model to study the pathology and pharmacological mechanisms of inflammatory bowel disease (IBD), thereby developing advanced therapeutic drugs. Immortalized cell lines, as a classic in vitro model, offer several advantages in the research and drug evaluation of IBD, such as high efficiency, low cost, simple operation and intuitive experimental results. However, these models cannot recapitulate the multicellular composition and intercellular interaction of intestinal tissue in vivo and may lose genetic characteristics after multiple passages in vitro. The development of organoids and organs-on-a-chip has promoted the technological innovation of in vitro models by significantly improving our capability to simulate the architecture and function of IBD. The enhanced reproducibility of the organoid model to the microenvironment of the source tissue also confers improved predictive capability for patient treatment response. This paper reviews the current research status of these models by discussing their characteristics, advantages, disadvantages, and their applications in evaluation of IBD therapeutic drugs and development of advanced therapeutic drugs, as well as in the exploration of pharmacological mechanisms.

inflammatory bowel disease  /  cell model  /  organoid  /  organs-on-a-chip
Pan LIU, Xueling LIU, Qingwei ZHAO. Research Progress in the Use of Cell Line and Organoid Models for Studying Inflammatory Bowel Disease[J]. Chinese Pharmaceutical Journal, 2024 , 59 (17) : 1558 -1564 . DOI: 10.11669/cpj.2024.17.002
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doi: 10.11669/cpj.2024.17.002
  • Receive Date：2024-05-26
  • Online Date：2025-12-30
  • Published：2024-09-08
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  • Received：2024-05-26
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Affiliations
    1 School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
    2 Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine for Clinical Evaluation and Translational Research, Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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