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Progress in the Application of Nano-drug Delivery System Based on Active Ingredients of Chinese Medicine for the Synergistic Treatment of Breast Cancer
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Mengmeng ZHANG1, Gaofan SHI2, Jing CHENG2, Yuehua LIAO2, *, Dongdong ZENG2, *
Chinese Pharmaceutical Journal | 2024, 59(12) : 1082 - 1092
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Chinese Pharmaceutical Journal | 2024, 59(12): 1082-1092
Progress in the Application of Nano-drug Delivery System Based on Active Ingredients of Chinese Medicine for the Synergistic Treatment of Breast Cancer
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Mengmeng ZHANG1, Gaofan SHI2, Jing CHENG2, Yuehua LIAO2, *, Dongdong ZENG2, *
Affiliations
  • 1 Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China
  • 2 School of Medical Devices, Shanghai University of Medicine & Health Sciences, Shanghai 201318,China
Published: 2024-06-22 doi: 10.11669/cpj.2024.12.003
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Active ingredients in Chinese medicine have great potential to be used in breast cancer treatment to improve the efficacy of existing breast cancer treatment strategies. By influencing different signaling pathways to produce different mechanisms of action, active ingredients in Chinese medicine enhance the sensitivity of tumor cells to the effects of chemical, hormonal or gene therapeutic agents, reduce toxic side effects or inhibit the efflux of anticancer drugs. In this paper, it is reviewed the strategies for the combination of Chinese herbal active ingredients with other breast cancer therapeutic agents, such as chemotherapeutic agents, hormones, gene agents, small molecule inhibitors and inorganic mixtures, and intelligently design nano-delivery systems to co-deliver Chinese herbal active ingredients and other breast cancer therapeutic agents for the synergistic treatment of breast cancer. Nanocarriers offer various advantages including improved solubility, increased stability and enhanced tumor targeting, thus overcoming the clinical application limitations of the active ingredients of TCM.

nanocarrier  /  co-delivery  /  traditional Chinese medicine  /  synergistic effect  /  breast cancer
Mengmeng ZHANG, Gaofan SHI, Jing CHENG, Yuehua LIAO, Dongdong ZENG. Progress in the Application of Nano-drug Delivery System Based on Active Ingredients of Chinese Medicine for the Synergistic Treatment of Breast Cancer[J]. Chinese Pharmaceutical Journal, 2024 , 59 (12) : 1082 -1092 . DOI: 10.11669/cpj.2024.12.003
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Year 2024 volume 59 Issue 12
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doi: 10.11669/cpj.2024.12.003
  • Receive Date：2023-02-28
  • Online Date：2025-11-25
  • Published：2024-06-22
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  • Received：2023-02-28
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    1 Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China
    2 School of Medical Devices, Shanghai University of Medicine & Health Sciences, Shanghai 201318,China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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