Home Journals Articles Updates About
CN
image
收藏切换
Research Progress of Targeted Nano-delivery System for Hepatocellular Carcinoma Based on Glycyrrhetinic Acid
收藏切换
PDF
Fuqing YAN1, Ju LIANG1, *, Yang LIN1, Yunyun ZHANG1, Wenlan WU2
Chinese Pharmaceutical Journal | 2024, 59(12) : 1065 - 1073
Less
收藏切换
Chinese Pharmaceutical Journal | 2024, 59(12): 1065-1073
Research Progress of Targeted Nano-delivery System for Hepatocellular Carcinoma Based on Glycyrrhetinic Acid
Full
Fuqing YAN1, Ju LIANG1, *, Yang LIN1, Yunyun ZHANG1, Wenlan WU2
Affiliations
  • 1 School of Chemistry and Chemical Engineering, Henan University of Science and Technology, Luoyang 471023, China
  • 2 School of Medicine, Henan University of Science and Technology, Luoyang 471023, China
Published: 2024-06-22 doi: 10.11669/cpj.2024.12.001
Outline
收藏切换

Targeted nano-drug delivery system (TNDDS) offers prominent advantages in drug delivery for treatment of hepatocellular carcinoma, targeting the tumor site via ligand-receptor interaction. TNDDS reduces the dosage of drug to fulfill the therapeutic index requirement, improving pharmacokinetics and biodistribution. Besides, it can sustain drug release for several days after single-dose administration. In recent years, glycyrrhetinic acid (GA) attracts much attention as a highly efficient ligand targeting to liver tumor. The superiority of GA is mainly reflected in its combination of efficient liver tumor targeting, superior anti-tumor activity and favorable biocompatibility. GA-based TNDDS to liver tumor possesses high site-specificity and therapeutic efficiency for chemotherapeutic drugs or genetic materials delivering. This paper focuses on the basic theory of GA as a ligand targeting to liver tumor and the researches advances in the development of GA-based nano-delivery systems. Through the review and summary in this paper, it is expected to systematically present current progress of GA-based liver tumor TNDDS for interested researchers, and provide references for the development of new delivery systems.

glycyrrhetinic acid  /  drug delivery system  /  nanocarrier  /  tumor targeting  /  hepatocellular carcinoma
Fuqing YAN, Ju LIANG, Yang LIN, Yunyun ZHANG, Wenlan WU. Research Progress of Targeted Nano-delivery System for Hepatocellular Carcinoma Based on Glycyrrhetinic Acid[J]. Chinese Pharmaceutical Journal, 2024 , 59 (12) : 1065 -1073 . DOI: 10.11669/cpj.2024.12.001
Appendix
Less
Year 2024 volume 59 Issue 12
PDF
180
96
Cite this Article
BibTeX
Article Info
doi: 10.11669/cpj.2024.12.001
  • Receive Date：2022-11-21
  • Online Date：2025-11-25
  • Published：2024-06-22
Article Data
Affiliations
History
  • Received：2022-11-21
Funding
Affiliations
    1 School of Chemistry and Chemical Engineering, Henan University of Science and Technology, Luoyang 471023, China
    2 School of Medicine, Henan University of Science and Technology, Luoyang 471023, China
References
Share
https://castjournals.cast.org.cn/joweb/zgyxzz/EN/10.11669/cpj.2024.12.001
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House