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Progress in CAR-T Cell therapy Combined with PD-1 Blockade Therapy for Solid Tumors
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Meng ZHENG1, 2, Yan WANG1, Liyan MIAO1, 2, *
Chinese Pharmaceutical Journal | 2024, 59(11) : 961 - 969
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Chinese Pharmaceutical Journal | 2024, 59(11): 961-969
Progress in CAR-T Cell therapy Combined with PD-1 Blockade Therapy for Solid Tumors
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Meng ZHENG1, 2, Yan WANG1, Liyan MIAO1, 2, *
Affiliations
  • 1 Department of Clinical Pharmacology Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
  • 2 Institute for Interdisciplinary Drug Research and Translational Sciences, Soochow University, Suzhou 215123, China
Published: 2024-06-08 doi: 10.11669/cpj.2024.11.002
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Recently, chimeric antigen receptor (CAR)-T cell therapy has made remarkable success in hematological malignancies but faces a series of challenges in solid tumors. One of the major problems is that CAR-T cells overexpress programmed death-1 (PD-1) in tumor microenvironment. Therefore, blocking PD-1 can rescue the effector functions of CAR-T cells and reduce tumor burden significantly. Herein, it is aimed to summarize the progress in preclinical and clinical research on immunotherapy of combining CAR-T cells with PD-1 blockade for solid tumors.

CAR-T  /  PD-1  /  solid tumor  /  immunotherapy
Meng ZHENG, Yan WANG, Liyan MIAO. Progress in CAR-T Cell therapy Combined with PD-1 Blockade Therapy for Solid Tumors[J]. Chinese Pharmaceutical Journal, 2024 , 59 (11) : 961 -969 . DOI: 10.11669/cpj.2024.11.002
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Year 2024 volume 59 Issue 11
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Article Info
doi: 10.11669/cpj.2024.11.002
  • Receive Date：2022-03-15
  • Online Date：2025-11-25
  • Published：2024-06-08
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  • Received：2022-03-15
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Affiliations
    1 Department of Clinical Pharmacology Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
    2 Institute for Interdisciplinary Drug Research and Translational Sciences, Soochow University, Suzhou 215123, China
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红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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