Home Journals Articles Updates About
CN
image
收藏切换
Research Progress in the Application of Inorganic Carriers in the Oral Delivery System of Protein and Peptide Drugs
收藏切换
PDF
Xiaodan SONG1, Kexin CONG1, Xiuting ZHOU1, Deying CAO1, Yupin SONG1, 2, *, Jian GAO1, 3, *, Bai XIANG1
Chinese Pharmaceutical Journal | 2024, 59(11) : 953 - 960
Less
收藏切换
Chinese Pharmaceutical Journal | 2024, 59(11): 953-960
Research Progress in the Application of Inorganic Carriers in the Oral Delivery System of Protein and Peptide Drugs
Full
Xiaodan SONG1, Kexin CONG1, Xiuting ZHOU1, Deying CAO1, Yupin SONG1, 2, *, Jian GAO1, 3, *, Bai XIANG1
Affiliations
  • 1 College of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
  • 2 Shijiazhuang University, Shijiazhuang 050035, China
  • 3 North China Pharmaceutical Company. Ltd, Shijiazhuang 050015, China
Published: 2024-06-08 doi: 10.11669/cpj.2024.11.001
Outline
收藏切换

The development of oral delivery systems for protein and peptide drugs has long been the goal of the pharmaceutical field. However, extremely low bioavailability has been an unsolved problem in this research. This is related to the physical and chemical properties of the protein and peptides, as well as the three physiological barriers: the complex pH and enzyme environment after oral administration, the mucus barrier and the intestinal epithelial tissue barrier. With its porous rigid structure and high drug loading and strong stability, inorganic particle carrier has the ability to penetrate mucus and transport intestinal epithelia after surface modification, thus overcoming the three physiological barriers. This study introduces the current clinical application of protein and peptide drugs for oral administration, and the mechanism and coping strategies of physiological barrier that limit their oral absorption. Additionally, the application of inorganic materials as carriers in the oral delivery system of protein and peptide drugs are summarized.

inorganic carriers  /  protein and peptide drug  /  oral delivery
Xiaodan SONG, Kexin CONG, Xiuting ZHOU, Deying CAO, Yupin SONG, Jian GAO, Bai XIANG. Research Progress in the Application of Inorganic Carriers in the Oral Delivery System of Protein and Peptide Drugs[J]. Chinese Pharmaceutical Journal, 2024 , 59 (11) : 953 -960 . DOI: 10.11669/cpj.2024.11.001
Appendix
Less
Year 2024 volume 59 Issue 11
PDF
161
78
Cite this Article
BibTeX
Article Info
doi: 10.11669/cpj.2024.11.001
  • Receive Date：2023-02-22
  • Online Date：2025-11-25
  • Published：2024-06-08
Article Data
Affiliations
History
  • Received：2023-02-22
Funding
Affiliations
    1 College of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
    2 Shijiazhuang University, Shijiazhuang 050035, China
    3 North China Pharmaceutical Company. Ltd, Shijiazhuang 050015, China
References
Share
https://castjournals.cast.org.cn/joweb/zgyxzz/EN/10.11669/cpj.2024.11.001
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House