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Analysis of Chemical Constituents of Zhuang Medicine Longzuan Tongbi Granules by LC-MS/MS
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Shuohan CHENG1, Xiaoying LEI1, Wen KANG1, Lan YAO1, Hang ZHANG1, Qinghuai ZHANG2, Yuzhou PANG2, Wenbin ZHOU1, 3, *, Abliz ZEPER1, 3
Chinese Pharmaceutical Journal | 2024, 59(9) : 818 - 826
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Chinese Pharmaceutical Journal | 2024, 59(9): 818-826
Analysis of Chemical Constituents of Zhuang Medicine Longzuan Tongbi Granules by LC-MS/MS
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Shuohan CHENG1, Xiaoying LEI1, Wen KANG1, Lan YAO1, Hang ZHANG1, Qinghuai ZHANG2, Yuzhou PANG2, Wenbin ZHOU1, 3, *, Abliz ZEPER1, 3
Affiliations
  • 1 Key Laboratory of Ethnomedicine, Ministry of Education, School of Pharmacy, Minzu University of China, Beijing 100081, China
  • 2 Guangxi University of Chinese Medicine, Nanning 530001, China
  • 3 Key Laboratory of Mass Spectrometry Imaging and Metabonomics, National Ethnic Affairs Commission, Ministry of Education, College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China
Published: 2024-05-08 doi: 10.11669/cpj.2024.09.007
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OBJECTIVE To analyze the chemical components of Longzuan Tongbi Granules, a classical prescription of Zhuang medicine by liquid chromatography-tandem mass spectrometry (LC-MS/MS). METHODS The MS/MS data were collected in positive and negative ion mode after gradient elution of the test solution using an ACQUITY UPLC HSS T3 column (2.1 mm×100 mm, 1.8 μm) and a mobile phase system consisting of 0.1% formic acid water (A)-0.1% formic acid acetonitrile (B). RESULTS A total of 113 compounds, including 64 alkaloids, 20 flavonoids, 12 organic acids, 8 coumarins, 5 lignans and 4 others, were identified by high-resolution mass spectrometry data analysis, reference substance and database comparison, while referring to the mass fragmentation patterns of relevant components reported in the literature, and of which 109 secondary metabolites were attributed for recognition. CONCLUSION The material basis of Longzuan Tongbi Granules is rich, represented by alkaloids, and Toddalia asiatica is the important “main drug”. This information can provide a scientific basis for the pharmacodynamic mechanism study and rational clinical use of this formula.

Longzuan Tongbi Granule  /  Zhuang medicine  /  alkaloid  /  flavonoid  /  LC-MS/MS  /  mass fragmentation pattern
Shuohan CHENG, Xiaoying LEI, Wen KANG, Lan YAO, Hang ZHANG, Qinghuai ZHANG, Yuzhou PANG, Wenbin ZHOU, Abliz ZEPER. Analysis of Chemical Constituents of Zhuang Medicine Longzuan Tongbi Granules by LC-MS/MS[J]. Chinese Pharmaceutical Journal, 2024 , 59 (9) : 818 -826 . DOI: 10.11669/cpj.2024.09.007
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doi: 10.11669/cpj.2024.09.007
  • Receive Date：2023-12-13
  • Online Date：2025-11-25
  • Published：2024-05-08
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  • Received：2023-12-13
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Affiliations
    1 Key Laboratory of Ethnomedicine, Ministry of Education, School of Pharmacy, Minzu University of China, Beijing 100081, China
    2 Guangxi University of Chinese Medicine, Nanning 530001, China
    3 Key Laboratory of Mass Spectrometry Imaging and Metabonomics, National Ethnic Affairs Commission, Ministry of Education, College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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