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OBJECTIVE To prepare a “sandwich” oral film (composed ofthe backing layer, sustained release layer, and adhesion layer) containing triamcinolone acetonide for the treatment of oral ulcers. METHODS Triamcinolone acetonide oral film was prepared by a tape casting process using ethyl cellulose (EC), hydroxypropyl methylcellulose (HPMC), and polyacrylic acid (PAA) as carrier materials. Taking the appearance, thickness, uniformity, adhesion, and mechanical strength of the film as indicators, the formulation of the backing layer, sustained release layer, and adhesion layer was optimized by a single factor study. The film's physicochemical properties and drug release in vitro were compared with the commercially available formulation Taisho®. RESULTS The drug loading of the resulting triamcinolone acetonide three-layer oral film was 96.0%, and the film had good uniformity, mechanical strength, and adhesion. The designed oral film had a release curve similarity factor f2 of 54.25 when compared to the commercially available formulation of Taisho®. CONCLUSION The quality of triamcinolone acetonide oral film prepared by the tape casting process is consistent with that of Taisho®. Moreover, the technology of this film is simple and feasible, with the potential for industrial conversion.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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