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OBJECTIVE To prepare tetrahydropalmatine gel emulsion with Bletilla striata polysaccharide, and investigate its stability and dissolution characteristics in vitro. METHODS The nascent soap method combined with high pressure homogenization method were used to prepare tetrahydropalmatine gel emulsion. Using the particle size and polydispersity index (PDI) as evaluation indexes, the single factor response surface method was used to screen the optimal prescription, and the biological properties of tetrahydropalmatine gel emulsion were investigated. RESULTS The optimum formula was m(Bletilla striata polysaccharide)-m(konjac gum)=50∶1, triethanolamine mass fraction of 0.8%, stearic acid mass fraction of 2.0%. The gel emulsion of tetrahydropalmatine was milky white, fine, uniform and glossy, and had good moisturizing, coating and stability properties. The average particle size and PDI value were about (1.56±0.04) μm, (0.434±0.03), and the cumulative transmittance of the gel emulsion for 24 h was (915.23±85.55) μg·cm-2. CONCLUSION The tetrahydropalmatine gel emulsion prepared in this experiment has good appearance, moisture retention, coating and stability, and good transdermal absorption rate. The research results can provide reference for the further development and utilization of tetrahydropalmatine.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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