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Bioaffinity monolithic chromatography is a chromatographic technology developed by combining the latest advances in biology, hylology and chemical analysis. Based on the basic principle of biological affinity, monolithic materials were used to prepare stationary phase, which can simulate intermolecular interactions in vivo to screen and purify active substances. This technology can specifically customize analysis methods for different target active substances and has been widely used in multiple research fields in pharmacy, chemistry and biology. This article focuses on the preparation methods of monolithic columns, systematically reviews the selection for chromatographic columns, as well as the strategies for affinity ligand immobilization such as covalent binding of biomolecules and biological labels. It also summarizes the relevant applications and development directions of bioaffinity monolithic columns in the preparation of active proteins and drug/biological analysis.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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