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In Vitro Transdermal Characteristics and Skin Irritation Evaluation of Liuwei Dihuang Gel
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Jiahua MEI1, 2, Yunkuan LIU1, Xiantao TAI1, Liuren LIN1, Hourong WANG1, Junfei CAI1, Yunshu MA1, 2, *
Chinese Pharmaceutical Journal | 2025, 60(1) : 66 - 70
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Chinese Pharmaceutical Journal | 2025, 60(1): 66-70
In Vitro Transdermal Characteristics and Skin Irritation Evaluation of Liuwei Dihuang Gel
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Jiahua MEI1, 2, Yunkuan LIU1, Xiantao TAI1, Liuren LIN1, Hourong WANG1, Junfei CAI1, Yunshu MA1, 2, *
Affiliations
  • 1 Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming 650500, China
  • 2 The Key Laboratory of External Drug Delivery System and Preparation Technology in University of Yunnan Province, Yunnan Key Laboratory of Dai and Yi medicines, Engineering Research Center for Medicine and Food Homologous Beverage of Yunnan Province, Kunming 650500, China
Published: 2025-01-08 doi: 10.11669/cpj.2025.01.008
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OBJECTIVE To study the in vitro transdermal characteristics of Liuwei Dihuang gel and evaluate the safety of skin medication. METHODS The improved vertical Franz diffusion cell method was used for in vitro transdermal experimental and the skin of rat was used as the permeation barrier. The cumulative permeation amount and rate of morroniside, loganin, and paeonol in the receiving medium were determined by HPLC, to investigate the in vitro transdermal characteristics of Liuwei Dihuang gel. The skin irritation was observed after single or multiple application of Liuwei Dihuang gel on intact and damaged skin of guinea pig. RESULTS The cumulative permeation amount of morroniside, loganin and paeonol within 12 h were 246.56, 298.47 and 369.89 μg·cm-2, and the cumulative permeation rate were 19.67%, 21.55% and 39.18%, respectively. Liuwei Dihuang gel is not irritating to both intact and damaged skin of guinea pigs. CONCLUSION The in vitro transdermal performance of Liuwei Dihuang gel is good. The in vitro transdermal process conforms to the Higuchi kinetic equation. It has no irritation effect on the skin of guinea pigs. It is safe and reliable for skin external use and has good linical application potential.

Liuwei Dihuang gel  /  high performance liquid chromatography  /  in vitro skin permeation feature  /  skin irritation
Jiahua MEI, Yunkuan LIU, Xiantao TAI, Liuren LIN, Hourong WANG, Junfei CAI, Yunshu MA. In Vitro Transdermal Characteristics and Skin Irritation Evaluation of Liuwei Dihuang Gel[J]. Chinese Pharmaceutical Journal, 2025 , 60 (1) : 66 -70 . DOI: 10.11669/cpj.2025.01.008
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Year 2025 volume 60 Issue 1
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doi: 10.11669/cpj.2025.01.008
  • Receive Date：2024-04-02
  • Online Date：2025-11-24
  • Published：2025-01-08
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  • Received：2024-04-02
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Affiliations
    1 Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming 650500, China
    2 The Key Laboratory of External Drug Delivery System and Preparation Technology in University of Yunnan Province, Yunnan Key Laboratory of Dai and Yi medicines, Engineering Research Center for Medicine and Food Homologous Beverage of Yunnan Province, Kunming 650500, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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