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Analysis of Chemical Constituents in Flower of Fritillaria unibracteata P. K. Hsiao et K. C. Hsia by UHPLC-Q-TOF-MS
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Yijie REN1, 2, Zhao GENG2, *, Chengjun HE2, Lian ZHONG2, Yan GOU2, Bixing GAO2, Jingzhe PU3, Yazhong ZHANG3, Zhichun ZHANG1, 2, Xiaohong Li1, *
Chinese Pharmaceutical Journal | 2025, 60(1) : 32 - 38
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Chinese Pharmaceutical Journal | 2025, 60(1): 32-38
Analysis of Chemical Constituents in Flower of Fritillaria unibracteata P. K. Hsiao et K. C. Hsia by UHPLC-Q-TOF-MS
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Yijie REN1, 2, Zhao GENG2, *, Chengjun HE2, Lian ZHONG2, Yan GOU2, Bixing GAO2, Jingzhe PU3, Yazhong ZHANG3, Zhichun ZHANG1, 2, Xiaohong Li1, *
Affiliations
  • 1 College of Food and Biological Engineering, Chengdu University, Chengdu 610106, China
  • 2 MIIT Public Service Platforms for Industrial Technological Base, NMPA Key Laboratory for Quality Evaluation of Traditional Chinese Medicine, Traditional Chinese Patent Medicine, Sichuan Institute for Drug Control(Sichuan Testing Center of Medical Devices), Chengdu 611731, China
  • 3 NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Anhui Institute for Food and Drug Control, Hefei 230051, China
Published: 2025-01-08 doi: 10.11669/cpj.2025.01.004
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OBJECTIVE To identify the chemical constituents in flower of Fritillaria unibracteata P. K. Hsiao et K. C. Hsia (F-F, Chinese: Anzibeimu Hua) by employing ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS) for the optimal utilization of Fritillaria cirrhosa D. Don (Chinese: Chuanbeimu) resources. METHODS The separation was conducted on Thermo Hypersil GOLD aQ column (2.1 mm×150 mm, 1.9 μm) eluted with methanol-0.1% formic acid in a gradient mode at a flow rate of 0.3 mL·min-1, the column temperature was maintained at 35 ℃, and positive and negative electrospray ionization(ESI) was adopted for determine the chromatographic effluents. RESULTS Through comparison with reference standards, precise molecular weight determination from primary mass spectrometry, and analysis of fragmentation patterns from secondary mass spectrometry, combined with existing literature, 71 chemical constituents were identified in F-F. These identified compounds encompass 24 alkaloids, 12 flavonoids, 9 amino acids, and additional substances, including the notable detection of peimine and peiminine within F-F. CONCLUSION This study employs UHPLC-Q-TOF-MS technology to conduct an exhaustive analysis of the chemical composition of F-F. From the results, it can be seen that the F-F possess potential medicinal value. This study provides scientific basis for the rational development and sustainable utilization of its resources.

Fritillaria unibracteata flower  /  UHPLC-Q-TOF-MS  /  chemical constituent identification  /  cleavage pattern
Yijie REN, Zhao GENG, Chengjun HE, Lian ZHONG, Yan GOU, Bixing GAO, Jingzhe PU, Yazhong ZHANG, Zhichun ZHANG, Xiaohong Li. Analysis of Chemical Constituents in Flower of Fritillaria unibracteata P. K. Hsiao et K. C. Hsia by UHPLC-Q-TOF-MS[J]. Chinese Pharmaceutical Journal, 2025 , 60 (1) : 32 -38 . DOI: 10.11669/cpj.2025.01.004
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Year 2025 volume 60 Issue 1
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Article Info
doi: 10.11669/cpj.2025.01.004
  • Receive Date：2024-07-15
  • Online Date：2025-11-24
  • Published：2025-01-08
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  • Received：2024-07-15
Funding
Affiliations
    1 College of Food and Biological Engineering, Chengdu University, Chengdu 610106, China
    2 MIIT Public Service Platforms for Industrial Technological Base, NMPA Key Laboratory for Quality Evaluation of Traditional Chinese Medicine, Traditional Chinese Patent Medicine, Sichuan Institute for Drug Control(Sichuan Testing Center of Medical Devices), Chengdu 611731, China
    3 NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Anhui Institute for Food and Drug Control, Hefei 230051, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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