PDF
Full
Outline
OBJECTIVE To predict the potential quality marker (Q-Marker) components of Suanzaoren Decoction based on the prototype chemical composition of in vivo by using network pharmacology. METHODS Firstly, the plasma samples and urine samples of rats were collected within 4 h and 24 h after intragastric administration of Suanzaoren Decoction, respectively. Then, based on the chemical components found in vivo, the key action targets and key pathway were obtained by network pharmacology, and the network map of "component-target-pathway" was carried out to predict the quality markers of Suanzaoren Decoction against insomnia, anxiety and depression. RESULTS A total of 20 prototype compounds were detected in rats. The 23 core targets were predicted and 14 prototype components associated with pharmacodynamic efficacy were screened through network pharmacology, the 14 components including jujuboside A, enoxolone, ferulic acid, magnoflorine, liquiritigenin, isoliquiritigenin, poricoic acid A, spinosin, coclaurine, timosaponin BII, glycyrrhizic acid, jujuboside B, liquiritin and senkyunolide A played multiple targets and multiple pathways to regulate insomnia, anxiety, depression. CONCLUSION It is predicted that the 14 chemical components are considered as potential quality markers of Suanzaoren Decoction by analyzing prototype chemical composition in vivo combined with network pharmacology. The results can provide reference for the quality control of Suanzaoren Decoction, and lay a foundation for elucidating the mechanism of its pharmacodynamic substances.
PDF
209
98
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
